Patents by Inventor Wolfgang Eisenreich
Wolfgang Eisenreich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8945632Abstract: The current invention provides therapeutic methods which include inhibition of nuclear factor ?b pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing different diseases such as cancer, inflammation, and virus infections.Type: GrantFiled: July 19, 2011Date of Patent: February 3, 2015Assignees: Ben Gurion University of the Negev R&D Authority, Mor Research Applications Ltd.Inventors: Avi Golan, Jacob Gopas, Janet Ozer, Nadav Eisner, Adelbert Bacher, Wolfgang Eisenreich, Elena Ostrozhenkova, Hila Winer
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Publication number: 20130122114Abstract: The current invention provides therapeutic methods which include inhibition of nuclear factor ?b pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing different diseases such as cancer, inflammation, and virus infections.Type: ApplicationFiled: July 19, 2011Publication date: May 16, 2013Inventors: Avi Golan, Jacob Gopas, Janet Ozer, Nadav Eisner, Adelbert Bacher, Wolfgang Eisenreich, Elena Ostrozhenkova-Wangemann, Hila Winer
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Publication number: 20090199313Abstract: The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for conferring herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.Type: ApplicationFiled: October 26, 2007Publication date: August 6, 2009Inventors: Adelbert Bacher, Meinhart H. Zenk, Petra Adam, Wolfgang Eisenreich, Monika Fellermeier, Stefan Hecht, Felix Rohdich, Christoph A. Schuhr, Juraithip Wungsintaweekul
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Patent number: 7534742Abstract: The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibitors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.Type: GrantFiled: September 25, 2006Date of Patent: May 19, 2009Inventors: Wolfgang Eisenreich, Monika Fellermeier, Markus Fischer, Stefan Hecht, Stefan Herz, Klaus Kis, Holger Lüttgen, Felix Rohdich, Silvia Sagner, Christoph A. Schuhr, Jurathip Wungsintaweekul, Adelbert Bacher, Meinhart H. Zenk
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Publication number: 20080318227Abstract: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.Type: ApplicationFiled: August 30, 2007Publication date: December 25, 2008Inventors: Adelbert Bacher, Felix Rohdich, Petra Adam, Sabine Amslinger, Wolfgang Eisenreich, Stefan Hecht
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Patent number: 7402408Abstract: Assay for testing a sample for the presence or absence of inhibition of the enzymatic conversion of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate into isopentenyl diphosphate and/or dimethylallyl diphosphate by the following steps: (a) reacting an aqueous mixture containing 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate, a 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphnte reductase, and a reducing agent under predetermined reaction conditions for a predetermined period of time; (b) analyzing the reaction mixture obtained in step (a) for the consumed amount of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate and/or NAD(P)H and/or for the produced amount of isopentenyl diphosphate, and/or dimethylallyl diphosphate and/or NAD(P)+; (c) repeating step (a) in the presence of the sample to be tested; (d) repeating step (b) with the reaction mixture defined in step (c); (e) comparing the results of steps (b) and (d).Type: GrantFiled: January 15, 2004Date of Patent: July 22, 2008Assignee: Adelbert BacherInventors: Adelbert Bacher, Petra Adam, Wolfgang Eisenreich, Tobias Gräwert, Stefan Hecht, Felix Rohdich, Ferdinand Zepeck
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Patent number: 7297509Abstract: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.Type: GrantFiled: April 10, 2002Date of Patent: November 20, 2007Inventors: Adelbert Bacher, Felix Rohdich, Petra Adam, Sabine Amslinger, Wolfgang Eisenreich, Stefan Hecht
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Patent number: 7288367Abstract: The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.Type: GrantFiled: June 1, 2001Date of Patent: October 30, 2007Inventors: Adelbert Bacher, Meinhart H. Zenk, Petra Adam, Wolfgang Eisenreich, Monika Fellermeier, Stefan Hecht, Felix Rohdich, Christoph A. Schuhr, Juraithip Wungsintaweekul
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Publication number: 20070015216Abstract: The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibitors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.Type: ApplicationFiled: September 25, 2006Publication date: January 18, 2007Inventors: Wolfgang Eisenreich, Monika Fellermeier, Markus Fischer, Stefan Hecht, Stefan Herz, Klaus Kis, Holger Luttgen, Felix Rohdich, Silvia Sagner-Grehn, Christoph Schuhr, Jurathip Wungsintaweekul, Adelbert Bacher, Meinhart Zenk
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Patent number: 7122331Abstract: The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibiors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.Type: GrantFiled: August 3, 2000Date of Patent: October 17, 2006Inventors: Wolfgang Eisenreich, Monika Fellermeier, Markus Fischer, Stefan Hecht, Stefan Herz, Klaus Kis, Holger Lüttgen, Felix Rohdich, Silvia Sagner-Grehn, Christoph A. Schuhr, Jurathip Wungsintaweekul, Adelbert Bacher, Meinhart H. Zenk
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Publication number: 20060099668Abstract: Assay for testing a sample for the presence or absence of inhibition of the enzymatic conversion of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate into isopentenyl diphosphate and/or dimethylallyl diphosphate by the following steps: a) reacting an aqueous mixture containing 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate, a 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate reductase, and a reducing agent under predetermined reaction conditions for a predetermined period of time; b) analyzing the reaction mixture obtained in step (a) for the consumed amount of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate and/or NAD(P)H and/or for the produced amount of isopentenyl diphosphate, and/or dimethylallyl diphosphate and/or NAD(P)+; c) repeating step (a) in the presence of the sample to be tested; d) repeating step (b) with the reaction mixture defined in step (c); e) comparing the results of steps (b) and (d).Type: ApplicationFiled: January 15, 2004Publication date: May 11, 2006Applicant: Adelbert BacherInventors: Adelbert Bacher, Petra Adam, Wolfgang Eisenreich, Tobias Grawert, Stefan Hecht, Felix Rohdich, Ferdinand Zepeck
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Publication number: 20040176570Abstract: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.Type: ApplicationFiled: April 7, 2004Publication date: September 9, 2004Inventors: Adelbert Bacher, Felix Rohdich, Petra Adam, Sabine Amslinger, Wolfgang Eisenreich, Stefan Hecht
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Publication number: 20040072142Abstract: The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.Type: ApplicationFiled: July 8, 2003Publication date: April 15, 2004Inventors: Adelbert Bacher, Meinhart H. Zenk, Petra Adam, Wolfgang Eisenreich, Monika Fellermeir, Stefan Hecht, Felix Rohdich, Christoph A. Schuhr, Juraithip Wungsintaweekul