Abstract: The invention is directed to a porous osteoinductive composite comprising osteoinductive granules embedded in a porous matrix, wherein more than 5% of the surface area of the osteoinductive granules is exposed from said matrix as determined by scanning electron microscopy (SEM) imaging. Such a composite can suitably be used in a medical treatment, for example in a medical treatment of connective tissue and/or bone loss or defect.

Abstract: The invention relates to a method for producing hot-rolled hot strip products in which a steel alloy is melted; the melted steel alloy is cast into slab ingots and after being heated to a temperature above Ac3, the slab ingots are hot rolled until they reach a desired degree of deformation and a desired strip thickness; the rolling is performed above the recrystallization temperature of the alloy; after the rolling, the strip is cooled to room temperature and for hardening purposes, is briefly heated to a temperature >Ac3 and cooled again, characterized in that the heating takes place with a temperature increase of more than 5 K/s, more than 10 K/s, more than 50 K/s, or more than 100 K/s and is kept at a desired target temperature for a period of 0.5 to 60 s before cooling to yield improved mechanical properties.

Abstract: The invention relates to a method for producing hot-rolled hot strip products in which a steel alloy is melted; the melted steel alloy is cast into slab ingots and after being heated to a temperature above Ac3, the slab ingots are hot rolled until they reach a desired degree of deformation and a desired strip thickness; the rolling is performed above the recrystallization temperature of the alloy; after the rolling, the strip is cooled to room temperature and for hardening purposes, is briefly heated to a temperature >Ac3 and cooled again, characterized in that the heating takes place with a temperature increase of more than 5 K/s, more than 10 K/s, more than 50 K/s, or more than 100 K/s and is kept at a desired target temperature for a period of 0.5 to 60 s before cooling to yield improved mechanical properties.

Abstract: The present invention refers to a dual vector system for production of one or more recombinant proteins in cells of insect origin comprising a first viral vector comprising a T7 promoter operably linked to a targeting sequence comprising a non-coding sequence and which expression can suppress one or more proteins essential for virus production, followed by a T7 termination sequence, and a second viral vector comprising a promoter operably linked to a T7 RNA polymerase encoding sequence, and at least one gene sequence located on the first and/or second vector encoding one or more recombinant proteins of interest. The invention further refers to recombinant insect cells comprising the dual vector system and methods for producing recombinant proteins using said dual vector CA system.

Abstract: The invention relates to a method for producing thermomechanically produced hot strip products in which a steel alloy is melted; the steel alloy is adjusted so that a recrystallization during the hot rolling is suppressed; the final rolling temperature is greater than 800° C.; the melted steel alloy is cast into slab ingots and after being heated to a temperature above Ac3, the slab ingots are hot rolled until they reach a desired degree of deformation and a desired strip thickness; after the rolling, the strip is cooled to room temperature and for hardening purposes, is briefly heated to a temperature >Ac3 and cooled again, characterized in that the heating takes place with a temperature increase of more than 5 K/s, more than 10 K/s, more than 50 K/s, or more than 100 K/s, and is kept at a desired target temperature for a period of 0.5 to 60 s before cooling to yield improved mechanical properties.

Abstract: A method for producing thermomechanically produced hot strip products in which a steel alloy is melted; the steel alloy is adjusted so that a recrystallization during the hot rolling is suppressed; the final rolling temperature is greater than 800° C.; the melted steel alloy is cast into slab ingots and after being heated to a temperature above Ac3, the slab ingots are hot rolled until they reach a desired degree of deformation and a desired strip thickness; after the rolling, the strip is cooled to room temperature and for hardening purposes, is briefly heated to a temperature>Ac3 and cooled again, characterized in that the heating takes place with a temperature increase of more than 5 K/s, more than 10 K/s, with more than 50 K/s, or more than 100 K/s and is kept at a desired target temperature for a period of 0.5 to 60 s before cooling to yield improved mechanical properties.

Abstract: In example embodiments, a radiation source uses Rydberg states to generate coherent THz radiation (e.g., in the range of 1-20 THz). The radiation source includes a pair of pump lasers (e.g., external-cavity diode lasers (ECDLs)) optically coupled (e.g., by a dichroic mirror and optical fiber) to a heated vapor cell (e.g., a vacuum chamber) holding an atomic species (e.g., rubidium (Rb)). The pump lasers optically pump the atomic species (e.g., Rb) to a predetermined Rydberg state (e.g., the nD5/2 state), which creates a population inversion between that state (e.g., the nD5/2 state) and a lower lying Rydberg state (e.g., the (n+1)P3/2 state). The emission between these two strongly dipole coupled Rydberg states generates coherent THz radiation.

Abstract: The present invention relates to new promoter sequences and uses thereof, in particular expression cassettes, vectors, and methods of expressing genes using the new promoters.

Abstract: In example embodiments, a radiation source uses Rydberg states to generate coherent THz radiation (e.g., in the range of 1-20THz). The radiation source includes a pair of pump lasers (e.g., external-cavity diode lasers (ECDLs)) optically coupled (e.g., by a dichroic mirror and optical fiber) to a heated vapor cell (e.g., a vacuum chamber) holding an atomic species (e.g., rubidium (Rb)). The pump lasers optically pump the atomic species (e.g., Rb) to a predetermined Rydberg state (e.g., the nD5/2 state), which creates a population inversion between that state (e.g., the nD5/2 state) and a lower lying Rydberg state (e.g., the (n+1)P3/2 state). The emission between these two strongly dipole coupled Rydberg states generates coherent THz radiation.

Abstract: Optical systems for focused light emission, which can be used as full color-capable pixels in grid assemblies, such as variable message signs and outdoor electronic display boards. The optical systems may include a light source that is a commercially available full-color LED in SMD design having a red, a green, and a blue LED crystal, which may be disposed at an inlet surface of a light-guiding rod having a constant cross-section and a jacket surface made of planes adjacent to each other at sharp edges. The light-guiding rod thereby captures the light substantially completely and completely mixes the different colors and brightnesses efficiently without scattering. The light output of the light-guiding rod lies at the focus of a convergent lens, which focuses the exiting light.

Abstract: A cell culture medium with high content of choline chloride is provided. The cell culture media further comprise only moderate amounts of amino acids, in particular the amount of glutamine in the cell culture media is limited. The cell culture media can be used for large scale production of polypeptides using cell cultures. The cell culture media with high content of choline chloride are particularly suitable for fed-batch cell culture whereby cell viabilities stay at a higher level for a longer time and high polypeptide titers although limited amounts of amino acids are used.

Abstract: A cell culture medium with high content of choline chloride is provided. The cell culture media further comprise only moderate amounts of amino acids, in particular the amount of glutamine in the cell culture media is limited. The cell culture media can be used for large scale production of polypeptides using cell cultures. The cell culture media with high content of choline chloride are particularly suitable for fed-batch cell culture whereby cell viabilities stay at a higher level for a longer time and high polypeptide titers although limited amounts of amino acids are used.

Abstract: A cell culture medium with high content of choline chloride is provided. The cell culture media further comprise only moderate amounts of amino acids, in particular the amount of glutamine in the cell culture media is limited. The cell culture media can be used for large scale production of polypeptides using cell cultures. The cell culture media with high content of choline chloride are particularly suitable for fed-batch cell culture whereby cell viabilities stay at a higher level for a longer time and high polypeptide titers although limited amounts of amino acids are used.

Abstract: Optical systems for focused light emission, which can be used as full color-capable pixels in grid assemblies, such as variable message signs and outdoor electronic display boards. The optical systems may include a light source that is a commercially available full-color LED in SMD design having a red, a green, and a blue LED crystal, which may be disposed at an inlet surface of a light-guiding rod having a constant cross-section and a jacket surface made of planes adjacent to each other at sharp edges. The light-guiding rod thereby captures the light substantially completely and completely mixes the different colors and brightnesses efficiently without scattering. The light output of the light-guiding rod lies at the focus of a convergent lens, which focuses the exiting light.

Abstract: A cell culture medium with high content of choline chloride is provided. The cell culture media further comprise only moderate amounts of amino acids, in particular the amount of glutamine in the cell culture media is limited. The cell culture media can be used for large scale production of polypeptides using cell cultures. The cell culture media with high content of choline chloride are particularly suitable for fed-batch cell culture whereby cell viabilities stay at a higher level for a longer time and high polypeptide titers although limited amounts of amino acids are used.

Abstract: The present invention relates to new promoter sequences and uses thereof, in particular expression cassettes, vectors, and methods of expressing genes using the new promoters.

Abstract: A sensor platform for use in sample analysis comprises a substrate (30) of refractive index (n1) and a thin, optically transparent layer (32) of refractive index (n2) on the substrate, (n2) is greater than (n1). The platform incorporates one or multiple corrugated structures in the form of periodic grooves (31), (33), which defines one or more sensing areas each for one or more capture elements. The grooves are so profiled, dimensioned and oriented that when coherent light is incident on the platform it is diffracted into individual beams or diffraction order resulting in reduction of the transmitted beam and an abnormal high reflection of the incident light thereby creates an enhanced evanescent field at the surface of the or each sensing area. The amplitude of this field at the resonant condition is greater by an order of approximately 100 than the field of prior art platforms so that the luminescence intensity created from samples on the platform is also increased by a factor of 100.

Abstract: Calibration and normalization methods for a grating-based sensor design are disclosed. The sensor may be constructed in a manner optimized for both label-free and luminescence, e.g. fluorescence, amplification detection in a single device. Such a sensor, based on grating or another periodical structure with appropriate coating, dramatically increases the diversity of applications and allows realizing novel concepts that provide qualitative and quantitative information/data for each location or capture element in the sensor surface. The invention takes advantage of these different modes to carry out a quality control (QC) step and a calibration of each individual location of the sensor. Thus, the assay data can be flagged according to their quality and local density variations, batch variations and variations in the printed deposition of probes or the materials to the surface can be compensated.

Abstract: Test circuit for testing a synchronous memory circuit having a frequency multiplication circuit which multiplies a clock frequency of a low-frequency clock signal received from an external test unit by a particular frequency multiplication factor a test data generator which produces test data on the basis of data control signals received from the external test unit and outputs them to a data output driver a first signal delay circuit for delaying the test data which are output by the test data generator by an adjustable first delay time, a second signal delay circuit for delaying data which are read out of the synchronous memory circuit and are received by a data input driver in the test circuit by an adjustable second delay time, and having a data comparison circuit which compares the test data produced by the test data generator with the data read out of the memory circuit and, on the basis of the comparison result, outputs an indicator signal to the external test unit which indicates whether the synchronou

Abstract: The method and the device generate digital signal patterns. Signal patterns or signal pattern groups are stored in a very small buffer register. The position of a following signal pattern or following signal pattern group is also stored in the form of a branch address, together with each signal pattern or each signal pattern group. A simple control logic circuit receives a control signal and determines whether the content of the currently addressed group is output continuously or the following group given by the branch address stored in the register is output after the currently selected group has been completely output. The novel method and device can advantageously be used for testing semiconductor memories and implemented in a cost-effective semiconductor circuit which is remote from a conventional test system.