Patents by Inventor Wolfgang F. Weckerle

Wolfgang F. Weckerle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of daunosamine hydrochloride from a D-mannose starting material
    Patent number: 4024333
    Abstract: A method for synthesizing daunosamine hydrochloride from methyl .alpha.-D-mannopyranoside. The major features of the preparative route involve the formation of a 2-deoxy-3-keto intermediate, whose oxime is reduced with high stereoselectivity to the D-ribo-3-amino compound, followed by a stereospecific step late in the sequence to introduce the terminal C-methyl group with inversion at C-5, to generate the required L-lyxo stereochemistry. The synthesis procedure affords daunosamine hydrochloride in 40% overall yield, with no chromatographic procedures for isolation being required in any of the steps.
    Type: Grant
    Filed: June 22, 1976
    Date of Patent: May 17, 1977
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: Derek Horton, Wolfgang F. Weckerle