Patents by Inventor Wolfgang Felzmann

Wolfgang Felzmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing ceftolozane from 7-aminocephalosporanic acid (7-ACA)
    Patent number: 10532058
    Abstract: The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7-ACA).
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: January 14, 2020
    Assignee: Sandoz AG
    Inventors: Michael Fischer, Wolfgang Felzmann, Ronny Huetz, Martin Langner, Birgit Endl
  • Process for Preparing Ceftolozane from 7-Aminocephalosporanic Acid (7-ACA)
    Publication number: 20180338981
    Abstract: The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7-ACA).
    Type: Application
    Filed: September 7, 2016
    Publication date: November 29, 2018
    Applicant: Sandoz AG
    Inventors: Michael Fischer, Wolfgang Felzmann, Ronny Huetz, Martin Langner, Birgit Endl
  • Active Acrylamides
    Publication number: 20180282336
    Abstract: The present invention refers to the synthesis and intermediates of substituted bicyclic compounds, which are used as a masked form of acrylamides and in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (ibrutinib) and its synthesis intermediates.
    Type: Application
    Filed: October 29, 2015
    Publication date: October 4, 2018
    Applicant: Sandoz AG
    Inventors: Wolfgang Felzmann, Stefanie Brunner, Hannes Lengauer
  • Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
    Publication number: 20170327504
    Abstract: The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula (I), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.
    Type: Application
    Filed: October 28, 2015
    Publication date: November 16, 2017
    Applicant: Sandoz AG
    Inventors: Christopher Rose, Herbert Silberger, Erwin Schreiner, Wolfgang Felzmann, Nenad Maras
  • PREPARATION OF ERTAPENEM INTERMEDIATES
    Publication number: 20170166570
    Abstract: The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof.
    Type: Application
    Filed: January 17, 2017
    Publication date: June 15, 2017
    Applicant: Sandoz AG
    Inventors: Hannes Lengauer, Birgit Endl, Wolfgang Felzmann
  • Preparation of ertapenem intermediates
    Patent number: 9546171
    Abstract: The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: January 17, 2017
    Assignee: Sandoz AG
    Inventors: Hannes Lengauer, Birgit Endl, Wolfgang Felzmann
  • Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including ?-amino acids prepared via Mukaiyama aldol addition
    Patent number: 9346853
    Abstract: The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: May 24, 2016
    Assignee: Sandoz AG
    Inventors: Kathrin Hoeferl-Prantz, Wolfgang Felzmann, Thorsten Wilhelm, David Benito-Garagorri
  • PREPARATION OF ERTAPENEM INTERMEDIATES
    Publication number: 20150274732
    Abstract: The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 1, 2015
    Applicant: Sandoz AG
    Inventors: Hannes Lengauer, Birgit Endl, Wolfgang Felzmann
  • SYNTHESIS OF TELAPREVIR AND BOCEPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF INCLUDING beta-AMINO ACIDS PREPARED VIA MUKAIYAMA ALDOL ADDITION
    Publication number: 20150183824
    Abstract: The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.
    Type: Application
    Filed: June 19, 2013
    Publication date: July 2, 2015
    Applicant: Sandoz AG
    Inventors: Kathrin Hoeferl-Prantz, Wolfgang Felzmann, Thorsten Wilhelm, David Benito-Garagorri
  • Regioselective acylation of rapamycin at the C-42 position
    Patent number: 9051336
    Abstract: The invention refers to the selective acylation of Rapamycin at the 42-position (I) with an acylating agent of the formula (II) wherein R4 and R5 are the same or different, individually the rest of an acetal, especially tetrahydropyran, or of a carbonate or the rest of a silyl ether or taken together are the rest of a boronate, an acetal or ketal.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: June 9, 2015
    Assignee: SANDOZ
    Inventors: Wolfgang Felzmann, Niklas Schone
  • PROCESS FOR THE SYNTHESIS OF TELAPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF
    Publication number: 20150038677
    Abstract: The invention relates to a process for the preparation of telaprevir, or a pharmaceutically acceptable salt or solvate thereof, wherein the process requires a smaller number of process steps and/or does not require the use of toxic and instable compounds compared to the known processes. Another embodiment refers to telaprevir, or a pharmaceutically acceptable salt or solvate thereof as well as to intermediate products for preparation of the same, wherein the afore-mentioned products are obtained by the process described herein.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 5, 2015
    Inventors: Wolfgang Felzmann, Stefanie Brunner, Thorsten Wilhelm
  • REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION
    Publication number: 20140081016
    Abstract: The invention refers to the selective acylation of Rapamycin at the 42-position (I) with an acylating agent of the formula (II) wherein R4 and R5 are the same or different, individually the rest of an acetal, especially tetrahydropyran, or of a carbonate or the rest of a silyl ether or taken together are the rest of a boronate, an acetal or ketal.
    Type: Application
    Filed: March 30, 2012
    Publication date: March 20, 2014
    Applicant: SANDOZ AG
    Inventors: Wolfgang Felzmann, Niklas Schone