Abstract: The invention relates to a method for the cleavage of a solid phase-bound polypeptide from the solid phase, the method comprising contacting the solid phase, to which the polypeptide is bound, with a composition consisting essentially of trifluoroacetic acid and 1,2-ethanedithiol, at a temperature in the range of about 23° C. to about 29° C.

Abstract: The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).

Abstract: The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).

Abstract: The invention relates to a method for the cleavage of a solid phase-bound polypeptide from the solid phase, the method comprising contacting the solid phase, to which the polypeptide is bound, with a composition consisting essentially of trifluoroacetic acid and 1,2-ethanedithiol, at a temperature in the range of about 23° C. to about 29° C.

Abstract: A component for the transmission and absorption of mechanical forces and moments includes at least one dimensionally stable component element having at least one hollow-profiled section extending along a longitudinal axis of the dimensionally stable component element, and at least one hollow-profiled component element consisting of fiber-reinforced plastic extending along a longitudinal axis of the hollow-profiled component element. The hollow-profiled component element is partially received by the hollow-profiled section of the dimensionally stable component element in a form-fitting manner. The component is produced by a method that includes the steps of inserting one end of the one hollow-profiled component element into the hollow-profiled section of the dimensionally stable component element and pressing the outer circumference (26) of the hollow-profiled component element (16) against the inner circumference (24) of the hollow-profiled section (14) by an inflatable element.

Abstract: A component for the transmission and absorption of mechanical forces and moments includes at least one dimensionally stable component element having at least one hollow-profiled section extending along a longitudinal axis of the dimensionally stable component element, and at least one hollow-profiled component element consisting of fibre-reinforced plastic extending along a longitudinal axis of the hollow-profiled component element. The hollow-profiled component element is partially received by the hollow-profiled section of the dimensionally stable component element in a form-fitting manner. The component is produced by a method that includes the steps of inserting one end of the one hollow-profiled component element into the hollow-profiled section of the dimensionally stable component element and pressing the outer circumference (26) of the hollow-profiled component element (16) against the inner circumference (24) of the hollow-profiled section (14) by an inflatable element.

Abstract: The invention relates to a component for absorbing and/or transmitting mechanical forces and/or moments, comprising at least one dimensionally stable component element (12, 12?, 12?, 2??, 12??), which has at least one hollow-profiled section (14), and at least one hollow-profiled component element (16) consisting of fiber-reinforced plastic, which can be partially received by the hollow-profiled section (14) of the dimensionally stable component element (12, 12?, 12?, 12??, 12??), and can be arranged in a form-fitting manner in the hollow-profiled section (14) of the dimensionally stable component element (12, 12?, 12?, 12??, 12??) by means of raised portions (32, 32?) which extend radially inwards and/or depressions (38, 38?), recesses or holes which extend radially outwards, wherein the inner circumference (24) of the hollow-profiled section (14) of the dimensionally stable component element (12, 12?, 12?, 12??, 12??) and the outer circumference (26) of the hollow-profiled component element (16) consisting

Abstract: The invention relates to a component for absorbing and/or transmitting mechanical forces and/or moments, comprising at least one dimensionally stable component element (12, 12?, 12?, 2??, 12??), which has at least one hollow-profiled section (14), and at least one hollow-profiled component element (16) consisting of fibre-reinforced plastic, which can be partially received by the hollow-profiled section (14) of the dimensionally stable component element (12, 12?, 12?, 12??, 12??), and can be arranged in a form-fitting manner in the hollow-profiled section (14) of the dimensionally stable component element (12, 12?, 12?, 12??, 12??) by means of raised portions (32, 32?) which extend radially inwards and/or depressions (38, 38?), recesses or holes which extend radially outwards, wherein the inner circumference (24) of the hollow-profiled section (14) of the dimensionally stable component element (12, 12?, 12?, 12??, 12??) and the outer circumference (26) of the hollow-profiled component element (16) consisting

Abstract: The invention relates to a test element for the testing of a liquid sample. The test element includes a sample application area, a test field, a sample transport path extending between the sample application area and the test field and an actuator field including a electrically-conductive layer. The actuator field is switchable between a first state attracting the sample and a second state attracting the sample less by applying to the conductive layer an electric voltage that is different from an earth potential. The actuator field has a section that is arranged at about the same distance from the sample application area as the test field, measured along the sample transport path, such that a wetting of the test field by the sample can be controlled by applying a voltage to the actuator field.

Abstract: The invention relates to a test element for the testing of a liquid sample. The test element includes a sample application area, a test field, a sample transport path extending between the sample application area and the test field and an actuator field including an electrically-conductive layer. The actuator field is switchable between a first state attracting the sample and a second state attracting the sample less by applying to the conductive layer an electric voltage that is different from an earth potential. The actuator field has a section that is arranged at about the same distance from the sample application area as the test field, measured along the sample transport path. Such that, a wetting of the test field by the sample can be controlled by applying a voltage to the actuator field.

Abstract: The invention concerns a method for producing integrated, diagnostic test elements (1) which have a lancing area (2) and a detection area (3). The lancing area is used to generate an opening in the skin and the detection area is used to detect an analyte in a body fluid. The selective sterilization sterilizes the lancing area but not the detection area by electron radiation. The method according to the invention comprises the steps of screening the detection area on the test element against electron radiation and subsequently irradiating the test element with electron radiation. The invention additionally concerns a method according to the invention in which the test elements and lancing areas are in a connected arrangement and are brought into the radiation area by moving the entire arrangement. Finally the invention concerns a diagnostic test element which has been produced according to the inventive method.

Abstract: The invention relates to a process for the preparation of a compound of the general formula (I) in which a) a compound (II) is reacted in the presence of a base B1 with a compound (III) and b) the compound (IV) formed as intermediate in step a) is reacted in the presence of a base B2 with a compound (V) to give the compound of the general formula (I)

Abstract: A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying the dispersion to a junction, a first drain channel for draining fluid having a reduced particle concentration away from the junction, and a second drain channel for draining fluid having an increased particle concentration away from the junction. The fluid flows so much faster in the second drain channel than in the first drain channel that due to the different flow speeds the dispersed particles preferentially flow at the junction further in the second drain channel.

Abstract: A fluidic structure and a method for production of a fluidic structure are provided. The method may comprise, in order, introducing at least one externally accessible opening into at least one base substrate of the fluidic structure, partially introducing at least one section of a fluidic conductor, which has at least one inner lumen and at least one conductor wall, in particular of a tube or flexible tube, into the at least one opening, introducing at least one curable fluid sealing material into the at least one opening, entirely or partially curing the at least one fluid sealing material, and producing at least one connecting channel between at least one inner lumen in the at least one fluidic conductor and at least one fluid channel in the fluidic structure, the at least one connecting channel passing through at least one conductor wall.

Abstract: The invention relates to a process for the preparation of a compound of the general formula (I) in which a) a compound (II) is reacted in the presence of a base B1 with a compound (III) and b) the compound (IV) formed as intermediate in step a) is reacted in the presence of a base B2 with a compound (V) to give the compound of the general formula (I)

Abstract: The invention concerns a method for producing integrated, diagnostic test elements (1) which have a lancing area (2) and a detection area (3). The lancing area is used to generate an opening in the skin and the detection area is used to detect an analyte in a body fluid. The selective sterilization sterilizes the lancing area but not the detection area by electron radiation. The method according to the invention comprises the steps of screening the detection area on the test element against electron radiation and subsequently irradiating the test element with electron radiation. The invention additionally concerns a method according to the invention in which the test elements and lancing areas are in a connected arrangement and are brought into the radiation area by moving the entire arrangement. Finally the invention concerns a diagnostic test element which has been produced according to the inventive method.

Abstract: The invention relates to a process for the preparation of a compound of the general formula (I) in which a) a compound (II) is reacted in the presence of a base B1 with a compound (III) and b) the compound (IV) formed as intermediate in step a) is reacted in the presence of a base B2 with a compound (V) to give the compound of the general formula (I)

Abstract: The invention relates to a test element for the testing of a liquid sample. The test element includes a sample application area, a test field, a sample transport path extending between the sample application area and the test field and an actuator field including an electrically-conductive layer. The actuator field is switchable between a first state attracting the sample and a second state attracting the sample less by applying to the conductive layer an electric voltage that is different from an earth potential. The actuator field has a section that is arranged at about the same distance from the sample application area as the test field, measured along the sample transport path.

Abstract: The invention relates to a process for the preparation of a compound of the general formula (I) in which a) a compound (II) is reacted in the presence of a base B1 with a compound (III) and b) the compound (IV) formed as intermediate in step a) is reacted in the presence of a base B2 with a compound (V) to give the compound of the general formula (I)

Abstract: A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate (5) with flow channels (3), comprising a feed channel (9) for supplying the dispersion to a junction (10), a first drain channel (11) for draining fluid having a reduced particle concentration away from the junction (10), and a second drain channel (12) for draining fluid having an increased particle concentration away from the junction (10). The fluid flows so much faster in the second drain channel than in the first drain channel (12) that due to the different flow speeds the dispersed particles preferentially flow at the junction (10) further in the second drain channel (12).