Patents by Inventor Wolfgang Fleck

Wolfgang Fleck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors
    Publication number: 20090227588
    Abstract: Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
    Type: Application
    Filed: November 14, 2006
    Publication date: September 10, 2009
    Inventors: Roman Wolfgang Fleck, Xin Guo, Ho Yin Lo, Chuk Chui Man
  • Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
    Patent number: 7405225
    Abstract: Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the I?B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: July 29, 2008
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles L. Cywin, Zhidong Chen, Jonathan Emeigh, Roman Wolfgang Fleck, Ming-Hong Hao, Eugene Hickey, Weimin Liu, Daniel Richard Marshall, Tina Morwick, Peter Nemoto, Ronald John Sorcek, Sanxing Sun, Jiang-Ping Wu
  • Substituted tricyclic heterocycles and their uses
    Patent number: 7291733
    Abstract: Disclosed are substituted tricyclic heterocycle compounds of the formulas (I), (II) and (III) shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: November 6, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles Lawrence Cywin, Roman Wolfgang Fleck, Eugene Richard Hickey, Weimin Liu, Tina Marie Morwick, John Robert Proudfoot, Denice M. Spero
  • Substituted benzimidazole compounds
    Patent number: 7138420
    Abstract: Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: November 21, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals Inc.
    Inventors: Joerg Martin Bentzien, Brian Nicholas Cook, Charles Cywin, Roman Wolfgang Fleck, Ho Yin Lo, Peter Allen Nemoto, Steven S. Pullen, Gregory Paul Roth, Roger John Snow, Hidenori Takahashi, Ji Wang, Kevin J. Moriarty, Lei Qiao, Michael Winters
  • Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
    Patent number: 6974870
    Abstract: Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the I?B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    Type: Grant
    Filed: December 6, 2003
    Date of Patent: December 13, 2005
    Assignee: Boehringer Ingelheim Phamaceuticals, Inc.
    Inventors: Charles L. Cywin, Can Mao, Jonathan Emeigh, Roman Wolfgang Fleck, Ming-Hong Hao, Eugene Hickey, Weimin Liu, Daniel Richard Marshall, Tina Morwick, Peter Nemoto, Ronald John Sorcek, Sanxing Sun, Jiang-Ping Wu, Erick Young, Darren DiSalvo, John Ginn, Pier Cirillo
  • Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
    Patent number: 6964956
    Abstract: Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the I?B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: November 15, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles L. Cywin, Zhidong Chen, Roman Wolfgang Fleck, Ming-Hong Hao, Eugene Hickey, Weimin Liu, Daniel Richard Marshall, Peter Nemoto, Ronald John Sorcek, Sanxing Sun, Jiang-Ping Wu, Tina Morwick, Jonathan Emeigh
  • Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
    Publication number: 20040180922
    Abstract: Disclosed are compounds of formula (I): 1
    Type: Application
    Filed: December 6, 2003
    Publication date: September 16, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles L. Cywin, Can Mao, Jonathan Emeigh, Roman Wolfgang Fleck, Ming-Hong Hao, Eugene Hickey, Weimin Liu, Daniel Richard Marshall, Tina Morwick, Peter Nemoto, Ronald John Sorcek, Sanxing Sun, Jiang-Ping Wu, Erick Young, Darren DiSalvo, John Ginn, Pier Cirillo
  • Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
    Publication number: 20040053957
    Abstract: Disclosed are compounds of formula (I): 1
    Type: Application
    Filed: June 3, 2003
    Publication date: March 18, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles L. Cywin, Zhidong Chen, Roman Wolfgang Fleck, Ming-Hong Hao, Eugene Hickey, Weimin Liu, Daniel Richard Marshall, Peter Nemoto, Ronald John Sorcek, Sanxing Sun, Jiang-Ping Wu, Tina Morwick, Jonathan Emeigh
  • Small molecules useful for the treatment of inflammatory disease
    Publication number: 20030232817
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: February 24, 2003
    Publication date: December 18, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventor: Roman Wolfgang Fleck
  • Small molecules useful in the treatment of inflammatory disease
    Publication number: 20030008848
    Abstract: Compound of the formula I, II, III or IV 1
    Type: Application
    Filed: December 5, 2001
    Publication date: January 9, 2003
    Inventors: Roman Wolfgang Fleck, Terence Alfred Kelly, Jin Mi Kim, Jinbo Lee, Rene Marc Lemieux, Ronald John Sorcek, Jiang-Ping Wu
  • Substituted aminopyrimidines
    Patent number: 4323570
    Abstract: The present invention is directed to certain aminopyrimidines of the general formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are hydrogen, halogen, alkoxy, alkylthio, or alkyl having 1 to 4 carbon atoms, or cycloalkyl having 3 to 5 carbon atoms and R.sup.4 is hydrogen or an aliphatic or aromatic acyl group, as well as physiologically compatible acid addition salts thereof. Compounds of the present invention are useful as blood pressure lowering agents and in the treatment of glaucoma.
    Type: Grant
    Filed: November 7, 1979
    Date of Patent: April 6, 1982
    Assignee: Beiersdorf Aktiengesellschaft
    Inventors: Wolfgang Stenzel, Wolfgang Fleck, Erich Cohnen, Ben Armah
  • Phenoxyalkylaminepyridylethers
    Patent number: 4152438
    Abstract: Phenoxyalkylaminepyridyl ethers of the formula ##STR1## wherein R.sub.1 is methyl, methoxy, or chlorine; R.sub.2 is hydrogen, methyl, alkoxy containing 1 to 4 carbon atoms, nitro, amino, halogen, cyano, or a residue of the formula ##STR2## N IS 2 OR 3, AND THEIR PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS. These compounds are useful for lowering blood pressure.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: May 1, 1979
    Assignee: Beiersdorf Aktiengesellschaft
    Inventors: Wolfgang Fleck, Rudolf Petersen, Heinrich Bahrmann
  • Phenoxyalkylamine containing pyridines having blood pressure reducing properties
    Patent number: 4054662
    Abstract: Compounds of the formula: ##STR1## (wherein R.sub.1 represents a chlorine atom or a methoxy or cyano group;R.sub.2 represents a hydrogen atom or a methyl or hydroxy group;m is 2, 3 or 4; andn is 1 or 2)And their physiologically acceptable acid addition salts have blood pressure reducing properties and may be used in the treatment of patients.
    Type: Grant
    Filed: March 23, 1976
    Date of Patent: October 18, 1977
    Assignee: Beiersdorf Aktiengesellschaft
    Inventors: Rudolf Theodor Petersen, Wolfgang Fleck
  • Therapeutically active phenoxyalkylamines
    Patent number: 4005096
    Abstract: Compounds of the formula: ##STR1## (wherein R.sub.1 represents a chlorine atom or a methoxy or cyano group;R.sub.2 represents a hydrogen atom or a methyl or hydroxy group;m is 2, 3 or 4; andn is 1 or 2)And their physiologically acceptable acid addition salts have blood pressure reducing properties and may be used in the treatment of patients.
    Type: Grant
    Filed: February 25, 1976
    Date of Patent: January 25, 1977
    Assignee: Biersdorf Aktiengesellschaft
    Inventors: Rudolf Theodor Petersen, Wolfgang Fleck
  • Phenoxyalkylamine containing pyridines
    Patent number: 3960878
    Abstract: Compounds of the formula: ##SPC1##(whereinR.sub.1 represents a chlorine atom or a methoxy or cyano group;R.sub.2 represents a hydrogen atom or a methyl or hydroxy group;m is 2, 3 or 4; andn is 1 or 2) and their physiologically acceptable acid addition salts have blood pressure reducing properties and may be used in the treatment of patients.
    Type: Grant
    Filed: December 13, 1974
    Date of Patent: June 1, 1976
    Assignee: Beiersdorf Aktiengesellschaft
    Inventors: Rudolf Theodor Petersen, Wolfgang Fleck