Patents by Inventor Wolfgang Fraefel

Wolfgang Fraefel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4952683
    Abstract: New compounds of the formula (I)-D and (I)-L as shown in the sheet of formulae are described, for example D- and L-erythro-1-(.beta.-D-glycopyranosyloxy)-3-hydroxy-2-palmitoylamino-4-tran s-octadecene, which exert actions promoting wound healing and cell and tissue regeneration, and can be used therapeutically for the treatment of wounds of any cause. They are prepared in good yield and in a stereochemically homogeneous form from ceramides of the formula (II)-D and/or (II)-L. The process comprises the protection of the 1-hydroxyl group, esterification of the 3-hydroxyl group, elimination of the 1-hydroxyl protective group, reaction with the trifluoroacetimidate or trichloroacetimidate of a 2,3,4,6-tetraacylated D-glucose and elimination of the O-acyl groups.
    Type: Grant
    Filed: December 24, 1987
    Date of Patent: August 28, 1990
    Assignee: Solco Basel AG
    Inventors: Roland Tschannen, Wolfgang Fraefel, Richard R. Schmidt, Rudolf Klager, Peter Zimmermann
  • Patent number: 4544552
    Abstract: Glycolipids having cell- and tissue-regenerating properties are isolated from the blood or organ homogenates of mammals by subjecting the starting material to autolysis and dialysis against an alcoholic-aqueous medium. The glycolipids can be isolated, and purified, from the resulting crude product by precipitation with ethanol or extraction followed by chromatography. The process gives relatively high yields of active compounds; it is outstandingly suitable for industrial application.
    Type: Grant
    Filed: May 26, 1983
    Date of Patent: October 1, 1985
    Assignee: Solco Basel AG
    Inventors: Wolfgang Fraefel, Roland Tschannen
  • Patent number: 4383832
    Abstract: The organ transplants are intended to be used as a replacement (prostheses) for organs or parts of organs, for examples arteries or veins, which have undergone pathological change or are functionally impaired. The organs, which are taken from a fish, bird or higher mammal, are subjected to crosslinking of the amino groups and of the alcoholic hydroxyl groups of the peptide chains of the intercellular matix by means of a di-, tri- or poly-carboxylic acid. It is advantageous subsequently to treat the crosslinked product with a dialdehyde, in order to bind amino groups which have not reacted, or to free the crosslinked product from material which potentially may act as an antigen, by hydrolysis with ficin, papain or a protease having a smaller action. After the hydrolysis, a comprehensive crosslinking is appropriately ensured using a dialdehyde or a di-, tri- or poly-carboxylic acid.
    Type: Grant
    Filed: July 1, 1982
    Date of Patent: May 17, 1983
    Assignee: Solco Basel AG
    Inventors: Wolfgang Fraefel, Heinz F. Lichti, Massimo Brunetti