Abstract: The present disclosure relates to a liquid pharmaceutical formulation comprising a DOSA-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.

Abstract: The invention relates to a dialysis cell for sample preparation for a chemical analysis method, in particular for ion chromatography. The dialysis cell comprises a donor channel and an acceptor channel extending parallel thereto. The donor channel and the acceptor channel are separated from each other by a selectively permeable dialysis membrane. In particular, an analyte that is dissolved in a donor solution in the donor channel can enter through the dialysis membrane into the acceptor solution in the acceptor channel. The acceptor channel has at least in some sections a volume that is smaller than the volume of the donor channel extending parallel thereto. Acceptor and donor channels are formed from half-cells, between which the dialysis membrane is arranged, wherein the donor channel and the acceptor channel are designed in each case as a recess in a contact surface of one of the half-cells with the dialysis membrane.

Abstract: The invention relates to a dialysis cell for sample preparation for a chemical analysis method, in particular for ion chromatography. The dialysis cell comprises a donor channel and an acceptor channel extending parallel thereto. The donor channel and the acceptor channel are separated from each other by a selectively permeable dialysis membrane. In particular, an analyte that is dissolved in a donor solution in the donor channel can enter through the dialysis membrane into the acceptor solution in the acceptor channel. The acceptor channel has at least in some sections a volume that is smaller than the volume of the donor channel extending parallel thereto. Acceptor and donor channels are formed from half-cells, between which the dialysis membrane is arranged, wherein the donor channel and the acceptor channel are designed in each case as a recess in a contact surface of one of the half-cells with the dialysis membrane.

Abstract: From an analysis probe to be analyzed, impurities such as proteins or solid matter are separated from the analytes to be analyzed by way of dialysis. An analysis solution containing the analytes is separated from an acceptor solution by a membrane of a dialysis cell. The membrane is chosen such that the analytes diffuse from the analysis solution through the membrane into the acceptor solution. In order to maintain as high as possible concentration of analytes in the acceptor solution, the analysis solution is constantly renewed. The acceptor solution remains stationary in an acceptor chamber until the concentration of analytes in the acceptor solution has reached a predetermined value, for example 95%.