Patents by Inventor Wolfgang G. Dippold

Wolfgang G. Dippold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies to cell surface antigens of human malignant melanoma
    Patent number: 4808704
    Abstract: Monoclonal antibody recognizing human melanoma cells, method of production and use.
    Type: Grant
    Filed: May 22, 1986
    Date of Patent: February 28, 1989
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Lloyd J. Old, Herbert F. Oettgen, Hisami Ikeda, Lucy T. C. Li, Kenneth O. Lloyd, Wolfgang G. Dippold
  • Method for detecting the presence of G.sub.D3 ganglioside
    Patent number: 4507391
    Abstract: Mouse monoclonal antibody AbR.sub.24 (Dippold et al., Proc. Natl. Acad. Sci. 77:6114-6118, 1980) has a high degree of specificity for human melanoma cells when tested on viable cultured cells using the PA-MHA serological assay. The antigen detected by this antibody has been isolated from melanoma cells and shown to be G.sub.D3 ganglioside by compositional and partial structural analysis and by comparison with authentic G.sub.D3 by thin layer chromatography (TLC). AbR.sub.24 reacts with authentic G.sub.D3, but not with any other ganglioside tested. Using TLC and reactivity with AbR.sub.24, a wide range of cells and tissues was examined for the presence of G.sub.D3. A new serological assay, termed glycolipid-mediated immune adherence (GMIA), was devised for assaying the reactivity of AbR.sub.24 with gangliosides. Melanomas (cultured cells or tumor tissue) were shown to have T.sub.D3 and G.sub.M3 as major gangliosides. Other cells and tissues examined also contained G.sub.D3, but usually only in low amounts.
    Type: Grant
    Filed: April 2, 1982
    Date of Patent: March 26, 1985
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Clifford S. Pukel, Kenneth O. Lloyd, Luiz R. Travassos, Wolfgang G. Dippold, Herbert F. Oettgen, Lloyd J. Old