Patents by Inventor Wolfgang Goehring

Wolfgang Goehring has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7288658
    Abstract: The present invention relates to a process for the manufacture of compounds of formula wherein the substituents are as described herein which comprises the steps of a) reacting a compound of formula with a compound of formula to form a compound of formula b) converting the OH/?O function of compounds of formula XIV/XIVa into a leaving group P with a reagent containing a leaving group, selected from POCl3, PBr3, MeI and (F3CSO2)2O to form a compound of formula wherein P is halogen or trifluoromethanesulfonate; c) substituting R2 for the leaving group P by reacting compound XV with HR2 to form a compound of formula and d) hydrolyzing the nitrile function in an acidic medium selected from H2SO4, HCl and acetic acid, to form a compound of formula I The compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds which have NK-1 antagonist activity.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: October 30, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Goehring, Peter John Harrington, Lewis M Hodges, David A Johnston, Goesta Rimmler
  • Patent number: 7259176
    Abstract: A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I and the corresponding salts, e.g. the sodium salts, are pharmaceutically active substances. Processes for the creation of intermediates are also disclosed.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Goehring, Ursula Hoffmann, Michelangelo Scalone, Helmut Stahr, Shaoning Wang
  • Publication number: 20050014792
    Abstract: The present invention relates to a process for the manufacture of compounds of formula wherein the substituents are as described herein which comprises the steps of a) reacting a compound of formula with a compound of formula to form a compound of formula b) converting the OH/?O function of compounds of formula XIV/XIVa into a leaving group P with a reagent containing a leaving group, selected from POCl3, PBr3, MeI and (F3CSO2)2O to form a compound of formula wherein P is halogen or trifluoromethanesulfonate; c) substituting R2 for the leaving group P by reacting compound XV with HR2 to form a compound of formula and d) hydrolyzing the nitrile function in an acidic medium selected from H2SO4, HCl and acetic acid, to form a compound of formula I The compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds which have NK-1 antagonist activity.
    Type: Application
    Filed: July 9, 2004
    Publication date: January 20, 2005
    Inventors: Wolfgang Goehring, Peter Harrington, Lewis Hodges, David Johnston, Goesta Rimmler
  • Publication number: 20040267023
    Abstract: A novel process for the preparation of compounds of formula I 1
    Type: Application
    Filed: June 21, 2004
    Publication date: December 30, 2004
    Inventors: Wolfgang Goehring, Ursula Hoffmann, Michelangelo Scalone, Helmut Stahr, Shaoning Wang
  • Patent number: 6274734
    Abstract: The present invention provides a process for the manufacture of pyrimidines of formula I: wherein R1, R2, R3 each independently represent hydrogen, C1-7-alkyl, or C1-7-alkoxy, A signifies —CN, a carbanionic R4-alkynyl residue, in which R4 is hydrogen or C1-7-alkyl, or a carbanionic residue of the malonic acid derivative of formula III  in which B and B′ independently represent —CN, —COOR5, or —C(O)R5, wherein R5 is alkyl or aryl.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: August 14, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventor: Wolfgang Göhring