Patents by Inventor Wolfgang Gohring

Wolfgang Gohring has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for making pyrimidine derivatives
    Patent number: 6274734
    Abstract: The present invention provides a process for the manufacture of pyrimidines of formula I: wherein R1, R2, R3 each independently represent hydrogen, C1-7-alkyl, or C1-7-alkoxy, A signifies —CN, a carbanionic R4-alkynyl residue, in which R4 is hydrogen or C1-7-alkyl, or a carbanionic residue of the malonic acid derivative of formula III  in which B and B′ independently represent —CN, —COOR5, or —C(O)R5, wherein R5 is alkyl or aryl.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: August 14, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventor: Wolfgang Göhring
  • Process for making pyrimidine derivatives
    Patent number: 6121447
    Abstract: The present invention provides a process for the manufacture of pyrimidines of formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 each independently represent hydrogen, C.sub.1-7 -alkyl, or C.sub.1-7 -alkoxy,A signifies--CN,a carbanionic R.sup.4 -alkynyl residue, in which R.sup.4 is hydrogen or C.sub.1-7 -alkyl, ora carbanionic residue of the malonic acid derivative of formula III ##STR2## in which B and B' independently represent --CN, --COOR.sup.5, or --C(O)R.sup.5, wherein R.sup.5 is alkyl or aryl.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: September 19, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Wolfgang Gohring
  • Process for the preparation of quinargine
    Patent number: 5914404
    Abstract: The present invention is concerned with a novel process for the manufacture of quinargine ##STR1## (N-(2-quinolylcarbonyl)-asparagine) based on the reaction of the succinimide ester ##STR2## with asparagine or asparagine salts in an aqueous reaction medium at a neutral pH value.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: June 22, 1999
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Wolfgang Gohring
  • Process for making pyrimidine derivatives
    Patent number: 5883254
    Abstract: The present invention provides a process for the manufacture of pyrimidines of formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 each independently represent hydrogen, C.sub.1-7 -alkyl, or C.sub.1-7 -alkoxy,A signifies --CN,a carbanionic R.sup.4 -alkynyl residue, in which R.sup.4 is hydrogen or C.sub.1-7 -alkyl, ora carbanionic residue of the malonic acid derivative of formula III ##STR2## in which B and B' independently represent --CN, --COOR.sup.5, or --C(O)R.sup.5, wherein R.sup.5 is alkyl or aryl.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: March 16, 1999
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Wolfgang Gohring