Patents by Inventor Wolfgang Greb
Wolfgang Greb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230248827Abstract: The invention relates to liposomes containing nanoparticles, wherein the nanoparticles are selected from magnetic, zparamagnetic, superparamagnetic and/or fluorescent and/or functionalized nanoparticles, and the liposomal sleeve contains lipid-derivatized bisphosphonic acid. The liposomes are suitable for preparing a solution for the diagnosis of pathological tissue degeneration or conversion processes on the bone and in the bone marrow, in particular for the treatment and diagnosis of bone tumors and bone metastases and disorders in the bone marrow (proliferative diseases of the blood-producing and lymphoreticular system).Type: ApplicationFiled: June 25, 2021Publication date: August 10, 2023Inventor: Wolfgang Greb
-
Publication number: 20220371979Abstract: The present invention relates to a continuous two-phase hydroformylation process for the production of aldehydes from olefins by means of carbon monoxide, hydrogen and a transition metal catalyst in a reaction zone, the transition metal being in the form of a water-soluble catalyst complex, wherein the process comprising the following steps once or several times: a) hydroformylating by reacting the olefins, carbon monoxide and hydrogen over a water-soluble transition metal catalyst comprising water-soluble organophosphorus ligands in the reaction zone; b) reducing the concentration of the olefins in the reaction zone by reducing the olefin feed to the reaction zone and withdrawing at least a portion of the catalyst solution from the reaction system, wherein the catalyst solution withdrawal and olefin concentration reduction substeps may occur in this or reverse order, simultaneously or sequentially; c) feeding a solvent, a transition metal source and water-soluble organophosphorus ligands to the reaction syType: ApplicationFiled: July 21, 2020Publication date: November 24, 2022Inventors: Alexander HENSEL, Ruben FERNANDEZ DIAZ, Wolfgang GREB, Jörg BOTTERHUIS, Gregor MEIER
-
Publication number: 20200002401Abstract: The present invention relates to a protein which binds to the domain encoded by exon 9 of human CD44 (CD44ex9), to fusion proteins and conjugates of said protein and especially to nanoparticles conjugated to said protein. The invention further relates to a method of production for the protein and the respective conjugated nanoparticles and the use of the protein of the invention for treatment and diagnosis of cancer diseases.Type: ApplicationFiled: July 15, 2019Publication date: January 2, 2020Inventors: CLAUDIA ARNTZ, WOLFGANG GREB
-
Publication number: 20170073392Abstract: The present invention relates to a protein which binds to the domain encoded by exon 9 of human CD44 (CD44ex9), to fusion proteins and conjugates of said protein and especially to nanoparticles conjugated to said protein. The invention further relates to a method of production for the protein and the respective conjugated nanoparticles and the use of the protein of the invention for treatment and diagnosis of cancer diseases.Type: ApplicationFiled: December 22, 2014Publication date: March 16, 2017Applicant: EXCHANGE IMAGING TECHNOLOGIES GMBHInventors: CLAUDIA ARNTZ, WOLFGANG GREB
-
Patent number: 8445728Abstract: The invention relates to a method for reprocessing a liquid product of a hydroformylation reaction, wherein the liquid phase produced in a release stage is supplied to a separating device from which a liquid flow containing rhodium is guided away via a filter, where solids thereby separated are taken out of the process and the filtrate obtained is guided back into the hydroformylation reaction.Type: GrantFiled: March 18, 2010Date of Patent: May 21, 2013Assignee: Oxea GmbHInventors: Wolfgang Greb, Rainer Lukas, Klaus Schmid, Wolfgang Zgorzelski, Jörg Arnold
-
Publication number: 20120108852Abstract: The invention relates to a method for reprocessing a liquid product of a hydroformylation reaction, wherein the liquid phase produced in a release stage is supplied to a separating device from which a liquid flow containing rhodium is guided away via a filter, where solids thereby separated are taken out of the process and the filtrate obtained is guided back into the hydroformylation reaction.Type: ApplicationFiled: March 18, 2010Publication date: May 3, 2012Inventors: Wolfgang Greb, Rainer Lukas, Klaus Schmid, Wolfgang Zgorzelski, Jörg Arnold
-
Publication number: 20120104039Abstract: A system for individual dosing of a medicament, in accordance with the individual pathological properties (“fingerprint”) of a patient—corresponding physiologically or genetically to the disease status is based on two components: the medicament that is to be taken or administered in a variable individual dosage and a miniaturized indicator system that obtains information from blood, saliva or other bodily fluids and tissues of the patient and displays the information in a readable form so that the patient or the treating physician can immediately read the optimal active substance to be taken or dosage to be administered.Type: ApplicationFiled: September 28, 2011Publication date: May 3, 2012Applicant: MCS MICRO CARRIER SYSTEMS GMBHInventors: Hans Schreier, Wolfgang Greb
-
Publication number: 20100330159Abstract: A stabilizer-free system for transporting active substances in a biological system of one or more active substances and magnetic particles, which is characterized in that the particles are provided with active substance(s) on at least part of their surface, is claimed. Modification of the magnetic particles is not absolutely required in this system. It can be incorporated both into aqueous and oily suspensions and into microemulsions, oil-in-water emulsions, water-in-oil emulsions and also water-in-oil-in-water emulsions.Type: ApplicationFiled: June 1, 2010Publication date: December 30, 2010Applicant: EUCRO EUROPEAN CONTRACT RESEARCH GMBH & CO. KGInventors: Helmut Blum, Marcel Roth, Wolfgang Greb
-
Publication number: 20100332029Abstract: A system for individual dosing of a medicament, in accordance with the individual pathological properties (“fingerprint”) of a patient—corresponding physiologically or genetically to the disease status is based on two components: the medicament that is to be taken or administered in a variable individual dosage and a miniaturized indicator system that obtains information from blood, saliva or other bodily fluids and tissues of the patient and displays the information in a readable form so that the patient or the treating physician can immediately read the optimal active substance to be taken or dosage to be administered.Type: ApplicationFiled: July 5, 2010Publication date: December 30, 2010Applicant: MCS Micro Carrier Systems GmbHInventors: Hans Schreier, Wolfgang Greb
-
Publication number: 20100272653Abstract: An imaging auxiliary for medical imaging methods contains stabilizer-free superparamagnetic particles such as metal oxides and metals. Preferred are ?-Fe2O3, Fe3O4, MnFe2O4, NiFe2O4, and CoFe2O4 and their mixtures. The auxiliary can additionally contain biologically and pharmacologically active substances such as proteins, antibodies, peptides, or oligonucleotides. The superparamagnetic particles have a particle size of 1 nm to 500 nm. A tissue-specific substance in the form of diphosphonic acids and physiologically innocuous salts of diphosphonic acids can be added.Type: ApplicationFiled: April 30, 2010Publication date: October 28, 2010Applicant: EUCRO EUROPEAN CONTRACT RESEARCH GMBH & CO. KGInventors: Wolfgang Greb, Helmut Blum, Marcel Roth
-
Publication number: 20100240764Abstract: The use of S-Clenbuterol for restoring and/or maintaining the function of partially or completely damaged/degenerated cells in the central nervous system and/or other nerve cells is claimed. The use of S-Clenbuterol leads to activation of astrocytes and initiation of endogenous processes of neuroprotection, it thus being possible for the damage or destruction of nerve cells to be reduced and, in some cases, even prevented.Type: ApplicationFiled: February 1, 2006Publication date: September 23, 2010Applicant: EUCRO EUROPEAN CONTRACT RESEARCH GMBH & CO. KGInventors: Wolfgang Greb, Josef Krieglstein, Carsten Culmsee
-
Patent number: 7455856Abstract: A bisphosphonic acid of the general formula (I) wherein R1 is H, OH, C1-C6 alkyl C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 halogen alkyl X is a direct bond, alkylen group with 1 to 20 carbon atoms, (CH3)m—(OCR3HCH2)n—(O)o—, wherein R3 is H or CH3 and m is 0 or a number from 1 to 6, n is a number from 1 to 10, preferably 1 to 6, and o is 0 or 1, —(CR4HCH2O)p—, wherein R4 is H or CH3, p is a number from 1 to 10, preferably 1 to 6, (CH3)q—(OCR5HCH2)r—(O)s—(CH3)t—, wherein R5 is H or CH3 and q is 0 or a number from 1 to 6, r is a number from 1 to 10, preferably 1 to 6, and s is 0 or 1, and t is a number from 1 to 6, R2 is a group of the formula (II) as well as their physiologically compatible derivatives in particular salts and trimethyl silyl derivatives.Type: GrantFiled: January 24, 2005Date of Patent: November 25, 2008Assignee: MCS Micro Carrier Systems GmbHInventors: Wolfgang Greb, Oleg Shyhskov, Gerd-Volker Röschenthaler, Verena Hengst
-
Publication number: 20070154537Abstract: A bisphosphonic acid of the general formula (I) wherein R1 is H, OH, C1-C6 alkyl C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 halogen alkyl X is a direct bond, alkylen group with 1 to 20 carbon atoms, (CH3)m—(OCR3HCH2)n—(O)o— wherein R3 is H or CH3 and m is 0 or a number from 1 to 6, n is a number from 1 to 10, preferably 1 to 6, and o is 0 or 1, ?—(CR4HCH2O)p— wherein R4 is H or CH3, p is a number from 1 to 10, preferably 1 to 6, ?(CH3)q—(OCR5HCH2)r—(O)s—(CH3)t—, wherein R5 is H or CH3 and q is 0 or a number from 1 to 6, r is a number from 1 to 10, preferably 1 to 6, and s is 0 or 1, and t is a number from 1 to 6, R2 is a group of the formula (II) as well as their physiologically compatible derivatives, in particular salts and trimethyl silyl derivatives.Type: ApplicationFiled: January 24, 2005Publication date: July 5, 2007Applicant: MCS MICRO CARRIER SYSTEMS GMBHInventors: Wolfgang Greb, Oleg Shyhskov, Gerd-Volker Roschenthaler, Verena Hengst
-
Publication number: 20060276669Abstract: An aqueous catalyst solution comprising rhodium and an aqueous solution comprising sulfonated arylphosphines by reacting arylphosphines with oleum to form a sulfonation mixture, diluting the sulfonation mixture with water, extracting the diluted sulfonation mixture with a solution of a water-insoluble amine in a water-insoluble organic solvent, reacting the resulting water-immiscible organic phase with a solution of an inorganic base in water, adjusting the resulting aqueous solution of sulfonated arylphosphines of pH of up to 3 by addition of an acid, and passing an inert gas stream through the aqueous solution comprising sulfonated arylphosphines until sulfur dioxide is no longer liberated from the aqueous solution of sulfonated arylphosphines.Type: ApplicationFiled: June 30, 2006Publication date: December 7, 2006Inventors: Michael Riedel, Ernst Wiebus, Carl Frohning, Wilfried Fenske, Florian Rampf, Jurgen Herwig, Helmut Bahrmann, Klaus Bergrath, Wolfgang Zgorzel-Ski, Robert Eckl, Hans Bohnen, Richard Fischer, Kurt Schalapski, Wolfgang Greb
-
Patent number: 7102034Abstract: A process for preparing sulfonated arylphosphines by reaction of arylphosphines with oleum, wherein, after reaction of the arylphosphines with oleum, the sulfonation mixture is firstly diluted with water, an inert gas stream is then passed through the diluted sulfonation mixture until SO2 is no longer liberated from the diluted sulfonation mixture and the latter is then worked up further in a customary manner and its use.Type: GrantFiled: December 8, 2004Date of Patent: September 5, 2006Assignee: Celanese Chemicals Europe GmbHInventors: Michael Riedel, Ernst Wiebus, Carl D Frohning, Wilfried Fenske, Florian Rampf, Jurgen Herwig, Helmut Bahrmann, Klaus Bergrath, Wolfgang Zgorzel-Ski, Robert Eckl, Hans Bohnen, Richard Fischer, Kurt Schalapski, Wolfgang Greb
-
Publication number: 20060182809Abstract: A stabilizer-free system for transporting active substances in a biological system of one or more active substances and magnetic particles is characterized in that the particles are provided with active substance(s) on at least part of their surface. Modification of the magnetic particles is not absolutely required in this system. It can be incorporated both into aqueous and oily suspensions and into microemulsions, oil-in-water emulsions, water-in-oil emulsions and also water-in-oil-in-water emulsions.Type: ApplicationFiled: March 29, 2006Publication date: August 17, 2006Applicant: EUCRO EUROPEAN CONTRACT RESEARCH GMBHInventors: Helmut Blum, Marcel Roth, Wolfgang Greb
-
Patent number: 7078393Abstract: In a method for preparing 1-hydroxy-1,1-diphosphonic acid compounds of the general formula I and/or of their pharmacologically compatible salts a compound of the formula II is reacted with a compound P(OSiR53)3-pR6p and the reaction product is hydrolyzed.Type: GrantFiled: March 12, 2002Date of Patent: July 18, 2006Assignee: EUCRO European Contract Research GmbH & Co. KGInventors: Helmut Blum, Wolfgang Greb, Yurii Pustovit, Gerd-Volker Röschenthaler
-
Publication number: 20060062733Abstract: In a system for individual dosing of a medicament, in accordance with the individual pathological properties (“fingerprint”) of a patient—corresponding physiologically or genetically to the disease status—two components are provided: a medicament that is to be taken or administered in a variable individual dosage and a miniaturized indicator system that obtains information from blood, saliva or other bodily fluids and tissues of the patient and displays the information in a readable form so that the patient or the treating physician can immediately read the optimal active substance to be taken or dosage to be administered.Type: ApplicationFiled: September 24, 2003Publication date: March 23, 2006Applicant: MCS Micro Carrier Systems GmbHInventors: Hans Schreier, Wolfgang Greb
-
Publication number: 20050171377Abstract: A process for preparing sulfonated arylphosphines by reaction of arylphosphines with oleum, wherein, after reaction of the arylphosphines with oleum, the sulfonation mixture is firstly diluted with water, an inert gas stream is then passed through the diluted sulfonation mixture until SO2 is no longer liberated from the diluted sulfonation mixture and the latter is then worked up further in a customary manner and its use.Type: ApplicationFiled: December 8, 2004Publication date: August 4, 2005Inventors: Michael Riedel, Ernst Wiebus, Carl Frohning, Wilfried Fenske, Florian Rampf, Jurgen Herwig, Helmut Bahrmann, Klaus Bergrath, Wolfgang Zgorzel-Ski, Robert Eckl, Hans Bohnen, Richard Fischer, Kurt Schalapski, Wolfgang Greb
-
Patent number: 6864387Abstract: A process for preparing solutions of sulfonated arylphosphines comprising reacting arylphosphines with oleum, diluting the sulfonation mixture with water, extracting the diluted sulfonation mixture with a solution of a water-insoluble organic solvent, reacting the organic phase with a solution of an inorganic base in water, adjusting the resulting aqueous solutin of sulfonated arylphosphines to a pH of up to 3 by addition of an acid, and passing an inert gas stream through the aqueous solution comprising sulfonated arylphosphines until sulfur is no longer liberated from the aqueous solution of sulfonated arylphosphines.Type: GrantFiled: April 14, 2003Date of Patent: March 8, 2005Assignee: Celanese Chemicals Europe GmbHInventors: Michael Riedel, Ernst Wiebus, Carl D Frohning, Wilfried Fenske, Florian Rampf, Jurgen Herwig, Helmut Bahrmann, Klaus Bergrath, Wolfgang Zgorzel-Ski, Robert Eckl, Hans Bohnen, Richard Fischer, Kurt Schalapski, Wolfgang Greb