Patents by Inventor Wolfgang Halfbrodt

Wolfgang Halfbrodt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulation of contrast media and process of preparation thereof
    Patent number: 11944690
    Abstract: The present disclosure relates to a liquid pharmaceutical formulation comprising a DOSA-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: April 2, 2024
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Stephan Holzschuh, Thomas Frenzel, Gregor Jost, Jessica Lohrke, Wolfgang Ebert, Thomas Brumby, Wolfgang Halfbrodt
  • FORMULATION OF CONTRAST MEDIA AND PROCESS OF PREPARATION THEREOF
    Publication number: 20220008562
    Abstract: The present disclosure relates to a liquid pharmaceutical formulation comprising a DOSA-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.
    Type: Application
    Filed: November 21, 2019
    Publication date: January 13, 2022
    Inventors: Stephan HOLZSCHUH, Thomas FRENZEL, Gregor JOST, Jessica LOHRKE, Wolfgang EBERT, Thomas BRUMBY, Wolfgang HALFBRODT
  • 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 7683081
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: March 23, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thorsten Blume, Bernd Elger, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Herbert Schneider
  • 1,2 diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7345075
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: March 18, 2008
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1,2 Diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7329679
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: February 12, 2008
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1-aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 7196202
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 27, 2007
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1,2 diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7115645
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 3, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • Microglia inhibitors for interrupting interleukin 12 and IFNgamma-mediated immune reactions
    Publication number: 20060211690
    Abstract: The invention describes the use of microglia inhibitors for the production of pharmaceutical agents that inhibit immune reactions that are mediated by monocytes, macrophages and T cells, and their use for treating T-cell-mediated immunological diseases and non-T-cell-mediated inflammation reactions.
    Type: Application
    Filed: February 9, 2006
    Publication date: September 21, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolf-Dietrich Doecke, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1,2 Diarylbenzimidazoles and their pharmaceutical use
    Publication number: 20060205803
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Application
    Filed: December 16, 2005
    Publication date: September 14, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1,2 Diarylbenzimidazoles and their pharmaceutical use
    Publication number: 20060094770
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Application
    Filed: December 8, 2005
    Publication date: May 4, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20050267160
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Application
    Filed: August 4, 2005
    Publication date: December 1, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6962932
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: November 8, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20050143439
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds.
    Type: Application
    Filed: February 24, 2005
    Publication date: June 30, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6903126
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: June 7, 2005
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6855714
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treating and for preventing diseases that are associated with microglia activation, as well as pharmaceutical preparations that contain these compounds.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: February 15, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Herbert Schneider, Bernd Elger
  • Microglia inhibitors for interrupting interleukin 12 and IFN-gamma-mediated immune reactions
    Publication number: 20040006117
    Abstract: The invention describes the use of microglia inhibitors for the production of pharmaceutical agents that inhibit immune reactions that are mediated by monocytes, macrophages and T cells, and their use for treating T-cell-mediated immunological diseases and non-T-cell-mediated inflammation reactions.
    Type: Application
    Filed: February 14, 2003
    Publication date: January 8, 2004
    Applicant: SCHERING AKTIENGESELLSCHAFT
    Inventors: Thorsten Blume, Wolf-Dietrich Doecke, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1-Phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20030229085
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Application
    Filed: February 14, 2003
    Publication date: December 11, 2003
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20030125550
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds.
    Type: Application
    Filed: July 9, 2002
    Publication date: July 3, 2003
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20030055057
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treating and for preventing diseases that are associated with microglia activation, as well as pharmaceutical preparations that contain these compounds.
    Type: Application
    Filed: July 5, 2002
    Publication date: March 20, 2003
    Applicant: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Herbert Schneider, Bernd Elger
  • 1,2 diarylbenzimdazoles and their pharmaceutical use
    Publication number: 20020006948
    Abstract: Benzimidazoles of general formula I 1
    Type: Application
    Filed: January 16, 2001
    Publication date: January 17, 2002
    Applicant: Schering AG
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning