Patents by Inventor Wolfgang Hell

Wolfgang Hell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
    Patent number: 11739049
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: August 29, 2023
    Assignee: Grünenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Helmut Heinrich Buschmann, Joerg Holenz, Stefan Gladow
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20210130282
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: January 6, 2021
    Publication date: May 6, 2021
    Applicant: GRÜNENTHAL GMBH
    Inventors: WOLFGANG HELL, OSWALD ZIMMER, HELMUT HEINRICH BUSCHMANN, JOERG HOLENZ, STEFAN GLADOW
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20200299225
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: June 9, 2020
    Publication date: September 24, 2020
    Applicant: GRUNENTHAL GMBH
    Inventors: WOLFGANG HELL, OSWALD ZIMMER, HELMUT HEINRICH BUSCHMANN, JOERG HOLENZ, STEFAN GLADOW
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20190263747
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: May 13, 2019
    Publication date: August 29, 2019
    Applicant: GRUNENTHAL GMBH
    Inventors: WOLFGANG HELL, OSWALD ZIMMER, HELMUT HEINRICH BUSCHMANN, JÖRG HOLENZ, STEFAN GLADOW
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20170217875
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: April 17, 2017
    Publication date: August 3, 2017
    Inventors: Wolfgang HELL, Oswald ZIMMER, Helmut Heinrich BUSCHMANN, Jörg HOLENZ, Stefan GLADOW
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20160221928
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: April 12, 2016
    Publication date: August 4, 2016
    Inventors: Wolfgang HELL, Oswald ZIMMER, Helmut Heinrich BUSCHMANN, Jörg HOLENZ, Stefan GLADOW
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20140378706
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventors: Wolfgang HELL, Oswald ZIMMER, Helmut Heinrich BUSCHMANN, Jorg HOLENZ, Stefan GLADOW
  • Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropy1)-phenol
    Patent number: 8877974
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: November 4, 2014
    Assignee: Grünenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Helmut Heinrich Buschmann, Joerg Holenz, Stefan Gladow
  • Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis
    Patent number: 8791300
    Abstract: Compounds of the formula II can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of R2 and R3 is not a hydrogen atom and the diphosphine ligand is chiral.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: July 29, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Wolfgang Hell, Markus Kegel, Helmut Buschmann, Felix Spindler, Detlef Heller, Hans-Joachin Drexler
  • Process for the preparation of (1r,4r)-6?-fluoro-(N,N-dimethyl- and N-methyl)-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4,b]indol]-4-amine
    Patent number: 8779160
    Abstract: A process for the preparation of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]indol]-4-amine and (1r,4r)-6?-fluoro-N-methyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]-indol]-4-amine or physiologically acceptable acid addition salts thereof.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: July 15, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Pruehs, Carsten Griebel, Wolfgang Hell
  • HCl Polymorphs of 3-((2-(Dimethylamino)methyl(cyclohex-1-yl))phenol
    Publication number: 20130245125
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)] phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Application
    Filed: May 1, 2013
    Publication date: September 19, 2013
    Applicant: GRUENENTHAL GmbH
    Inventors: Michael GRUSS, Andreas FISCHER, Markus KEGEL, Wolfgang HELL, Markus VON RAUMER, Joerg BERGHAUSEN, Susan Margaret DE PAUL
  • Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride
    Patent number: 8309610
    Abstract: This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: November 13, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Helmut Buschmann, Andreas Fischer, Wolfgang Hell, Dagmar Lischke
  • Preparation of 3-[(1,2)-3-(dimethylamino)-1ethyl-2-methylpropyl]phenol
    Patent number: 8263809
    Abstract: The present invention relates to an improved process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: September 11, 2012
    Assignee: Gruenenthal GmbH
    Inventor: Wolfgang Hell
  • Salt of Dimethylaminomethyl-Phenyl-Cyclohexane and Crystalline Forms Thereof
    Publication number: 20120178809
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: March 14, 2012
    Publication date: July 12, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • CRYSTALLINE FORMS OF (1RS,2RS,6RS)-6-DIMETHYLAMINOMETHYL-1-(3-METHOXYPHENYL)CYCLOHEXANE-1,3-DIOL HYDROCHLORIDE
    Publication number: 20110306673
    Abstract: This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.
    Type: Application
    Filed: February 21, 2006
    Publication date: December 15, 2011
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael Gruss, Helmut Buschmann, Andreas Fischer, Wolfgang Hell, Dagmar Lischke
  • HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol
    Patent number: 8058476
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: November 15, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Andreas Fischer, Markus Kegel, Wolfgang Hell, Markus Von Raumer, Joerg Berghausen, Susan Margaret Paul
  • HCI POLYMORPHS OF 3-((2-(DIMETHYLAMINO)METHYL (CYCLOHEX-1-YL))PHENOL
    Publication number: 20110251287
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Application
    Filed: June 21, 2011
    Publication date: October 13, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Andreas Fischer, Markus Kegel, Wolfgang Hell, Markus Von Raumer, Joerg Berghausen, Susan Margaret Paul
  • Salt of Dimethylaminomethyl-Phenyl-Cyclohexane and Crystalline Forms Thereof
    Publication number: 20110046230
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: August 12, 2010
    Publication date: February 24, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
    Patent number: 7884247
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: February 8, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • Process for producing 6-dimethylaminomethyl-phenyl-cyclohexane-1,3-diols
    Patent number: 7858826
    Abstract: A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: December 28, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Markus Kegel, Olaf Schaefer, Felix Spindler, Anita Schnyder, Urs Siegrist, Detlef Heller, Hans-Joachim Drexler