Patents by Inventor Wolfgang Ise

Wolfgang Ise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulation of an antibody and use thereof
    Patent number: 11576863
    Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: February 14, 2023
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Markus Rast, Wolfgang Ise, Gerhard Becker, Peter Skufca, Henning Gieseler
  • Formulation of an antibody and use thereof
    Patent number: 11433029
    Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: September 6, 2022
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Markus Rast, Wolfgang Ise, Gerhard Becker, Peter Skufca, Henning Gieseler
  • FORMULATION OF AN ANTIBODY AND USE THEREOF
    Publication number: 20160022585
    Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Markus RAST, Wolfgang ISE, Gerhard BECKER, Peter SKUFCA, Henning GIESELER
  • Method for Preparation of a High Concentration Liquid Formulation of an Antibody
    Publication number: 20150266965
    Abstract: The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof.
    Type: Application
    Filed: October 31, 2013
    Publication date: September 24, 2015
    Inventors: Markus Rast, Peter Skufca, Wolfram Steinhilber, Gerhard Becker, Jürgen Volz, Wolfgang Ise
  • FORMULATION OF AN ANTIBODY AND USE THEREOF
    Publication number: 20140271636
    Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Applicant: Takeda GmbH
    Inventors: Markus RAST, Wolfgang ISE, Gerhard BECKER, Peter SKUFCA, Henning GIESELER
  • METHOD FOR PREPARATION OF A HIGH CONCENTRATION LIQUID FORMULATION OF AN ANTIBODY
    Publication number: 20140120086
    Abstract: The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof.
    Type: Application
    Filed: October 31, 2013
    Publication date: May 1, 2014
    Applicant: Takeda GmbH
    Inventors: Markus RAST, Peter SKUFCA, Wolfram STEINHILBER, Gerhard BECKER, Jurgen VOLZ, Wolfgang ISE
  • Determination of the hydrophobic pulmonary surfactant protein SP-C
    Patent number: 6737243
    Abstract: Methods for determining the strongly hydrophobic pulmonary surfactant protein SP-C, SP-C specific antibody and a reagent kit for carrying out the methods are described.
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: May 18, 2004
    Assignee: Altana Pharma AG
    Inventors: Wolfgang Ise, Wolfram Steinhilber, Andreas Günther, Reinhold Schmidt
  • Process for separating and analyzing hydrophobic proteins using thin layer chromatography
    Patent number: 6599752
    Abstract: This-layer chromatography is used to separate, identify and quantity hydrophobic protein, hydrophobic protein fragment, hydrophobic modified protein and hydrophobic peptide. A method is thus provided for determination of proteins and peptides which, due to their low solubility in an aqueous solvent system, cannot be determined by conventional methods, such as ELISA, which are based on aqueous solvent systems.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: July 29, 2003
    Assignee: Altana Pharma AG
    Inventors: Wolfgang Ise, Rüdiger Nave, Wolfram Steinhilber
  • PROCESS FOR SEPARATING AND ANALYZING HYDROPHOBIC PROTEINS USING THIN LAYER CHROMATOGRAPHY
    Publication number: 20030138966
    Abstract: This-layer chromatography is used to separate, identify and quantify hydrophobic protein, hydrophobic protein fragment, hydrophobic modified protein and hydrophobic peptide. A method is thus provided for determination of proteins and peptides which, due to their low solubility in an aqueous solvent system, cannot be determined by conventional methods, such as ELISA, which are based on aqueous solvent systems.
    Type: Application
    Filed: November 13, 1998
    Publication date: July 24, 2003
    Inventors: WOLFGANG ISE, RUDIGER NAVE, WOLFRAM STEINHILBER