Abstract: The present application relates to the use of a phthalazinedione in the prevention or treatment of sequelae of a SARS-CoV-2 infection. Pharmaceutical compositions, combinations, advantageous formulation techniques and a method of treatment are disclosed.

Abstract: In an embodiment an integrated circuit comprises a plurality of ports. Of a plurality of gating circuits, each gating circuit blocks or grants access to at least one of the ports depending on a release signal. From a plurality of configuration registers, each configuration register for stores the information to which group a gating circuit of the plurality of gating circuits belongs. A tag evaluation circuit receives an identifier from an access request from a component and outputs a group identifier for the access. There is a plurality of comparison circuits. Each comparison circuit compares the group identifier with the content of one of the configuration registers and outputs the release signal to a gating circuit of the plurality of gating circuits.

Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Abstract: An electronic key having the following features. The electronic key has a key housing and a switch housing in the key housing. The switch housing has an inherently rigid frame having at least one first breakout, and a flexibly deformable membrane which is arranged on the frame in order to close the at least one breakout and to forward a force having effect from the outside on the membrane in the region of the breakout to an electrical switch element arranged within the frame. An electronic key having the required amount of stiffness is thus created, in which sensitive electronic components located therein are also protected from environmental influences. If the deformable membrane is not only used for button-related functions, but also for forming an ejection section for an emergency key or as a rattle protection for the emergency key, a multifunctional switch housing can thus be created simply.

Abstract: A portable electronic user device, in the form of an electronic key, having an inherently rigid button for activation by a user. The portable electronic user device further has a flexibly deformable membrane including a first side having at least one support section on which the at least one button is supported via the plunger, and an actuating section, separate from the at least one support section, for receiving and forwarding an actuation of the button to an electrical switch element. There is a rigid frame which bears the membrane on a second side opposite the first side, wherein, in the assembled state, having the membrane in the region of the at least one support section, the frame has at least one breakout, via which the membrane is moveable by the plunger upon activating the at least one button and, in dependence on the size and/or the shape of the breakout, provides a force for resetting the button.

Abstract: An electronic key having the following features. The electronic key has a key housing and a switch housing in the key housing. The switch housing has an inherently rigid frame having at least one first breakout, and a flexibly deformable membrane which is arranged on the frame in order to close the at least one breakout and to forward a force having effect from the outside on the membrane in the region of the breakout to an electrical switch element arranged within the frame. An electronic key having the required amount of stiffness is thus created, in which sensitive electronic components located therein are also protected from environmental influences. If the deformable membrane is not only used for button-related functions, but also for forming an ejection section for an emergency key or as a rattle protection for the emergency key, a multifunctional switch housing can thus be created simply.

Abstract: A portable electronic user device, in the form of an electronic key, having an inherently rigid button for activation by a user. The portable electronic user device further has a flexibly deformable membrane including a first side having at least one support section on which the at least one button is supported via the plunger, and an actuating section, separate from the at least one support section, for receiving and forwarding an actuation of the button to an electrical switch element. There is a rigid frame which bears the membrane on a second side opposite the first side, wherein, in the assembled state, having the membrane in the region of the at least one support section, the frame has at least one breakout, via which the membrane is moveable by the plunger upon activating the at least one button and, in dependence on the size and/or the shape of the breakout, provides a force for resetting the button.

Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Abstract: There is described a high speed vertical-cavity surface-emitting laser (VCSEL) comprising a substrate and first and second distributed Bragg reflectors (DBRs) disposed on the substrate, each comprising a stack of layers of alternating refractive index. A resonant cavity is disposed between the DBRs and an active region disposed in the resonant cavity. The resonant cavity is formed of material having low refractive index and has an optical thickness in a direction perpendicular to the substrate of ½?, where ? is the wavelength of light emitted by the VCSEL.

Abstract: A vertical cavity surface emitting laser (VCSEL) (100) has a substrate (104), on which are disposed first and second distributed Bragg reflectors (DBRs) (106, 112), each DBR comprising a stack of layers of alternating refractive index, an active layer (108) disposed between the DBRs, and an aperture layer (110) disposed either between the DBRs or within one of the DBRs. The aperture layer (110) has a border (116) having an internal boundary with a plurality of indented portions defining one or more apertures. Such a VCSEL is easily manufacturable and provides a narrow bandwidth output, as well as mitigating at least some of the problems of prior art VCSELs. Mesa (102) may be etched to be non-circular and subsequent selective oxidation of aperture layer (110) results in a non-circular current confinement aperture (114) promoting higher-order lateral modes (LP21).

Abstract: A method for evaluating a target molecule bound to a probe molecule provided with a marker includes: applying AC voltage between a working electrode provided on a substrate and a counter electrode; and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine at least one of a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, a binding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween.

Abstract: A vertical cavity surface emitting laser (VCSEL) (100) has a substrate (104), on which are disposed first and second distributed Bragg reflectors (DBRs) (106, 112), each DBR comprising a stack of layers of alternating refractive index, an active layer (108) disposed between the DBRs, and an aperture layer (110) disposed either between the DBRs or within one of the DBRs. The aperture layer (110) has a border (116) having an internal boundary with a plurality of indented portions defining one or more apertures. Such a VCSEL is easily manufacturable and provides a narrow bandwidth output, as well as mitigating at least some of the problems of prior art VCSELs. Mesa (102) may be etched to be non-circular and subsequent selective oxidation of aperture layer (110) results in a non-circular current confinement aperture (114) promoting higher-order lateral modes (LP21).

Abstract: Disclosed is a semiconductor laser in which the substrate comprises at least three independent functional sections in the direction of light wave propagation, said functional sections serving different functions and being individually triggered by means of electrodes via electrode leads. An intensification zone, a grid zone, and a phase adjustment zone are provided as functional sections. The light wave is optically intensified in the intensification zone while the phase of the advancing and returning wave is adjusted in the phase adjustment zone. The grid zone is used for selecting the wavelength and adjusting the intensity of coupling between the intensification zone and the phase adjustment zone.

Abstract: A method for evaluating a target molecule bound to a probe molecule provided with a marker includes: applying AC voltage between a working electrode provided on a substrate and a counter electrode; and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine at least one of a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, a binding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween.

Abstract: Disclosed is a semiconductor laser in which the substrate comprises at least three independent functional sections in the direction of light wave propagation, said functional sections serving different functions and being individually triggered by means of electrodes via electrode leads. An intensification zone, a grid zone, and a phase adjustment zone are provided as functional sections. The light wave is optically intensified in the intensification zone while the phase of the advancing and returning wave is adjusted in the phase adjustment zone. The grid zone is used for selecting the wavelength and adjusting the intensity of coupling between the intensification zone and the phase adjustment zone.

Abstract: Disclosed is a semiconductor laser (10) in which the substrate (11) comprises at least three independent functional sections (17, 20, 23) in the direction of light wave propagation (A), said functional sections (17, 20, 23) serving different functions and being individually triggered by means of electrodes (15, 18, 21) via electrode leads (16, 19, 22). An intensification zone (17), a grid zone (20), and a phase adjustment zone (23) are provided as functional sections. The light wave is optically intensified in the intensification zone (17) while the phase of the advancing and returning wave is adjusted in the phase adjustment zone (23). The grid zone (20) is used for selecting the wavelength and adjusting the intensity of coupling between the intensification zone (17) and the phase adjustment zone (23).

Abstract: Disclosed is a semiconductor laser (10) in which the substrate (11) comprises at least three independent functional sections (17, 20, 23) in the direction of light wave propagation (A), said functional sections (17, 20, 23) serving different functions and being individually triggered by means of electrodes (15, 18, 21) via electrode leads (16, 19, 22). An intensification zone (17), a grid zone (20), and a phase adjustment zone (23) are provided as functional sections. The light wave is optically intensified in the intensification zone (17) while the phase of the advancing and returning wave is adjusted in the phase adjustment zone (23). The grid zone (20) is used for selecting the wavelength and adjusting the intensity of coupling between the intensification zone (17) and the phase adjustment zone (23).

Abstract: Before each actual resistance measurement, a first preliminary measurement with short-circuited measuring circuit and a second preliminary measurement with the measuring circuit operating at no-load are carried out. From the measured values of the preliminary measurement steps, a weighting factor is calculated, by which, subsequently, the difference between the actual measured value and the short-circuit value is multiplied to form the actual measurement results.

Abstract: A method is disclosed for measuring telephone dial pulse parameters independent of telephone subscriber line length. To avoid distortions resulting from varying subscriber line lengths, there is performed during the first pulse interval of a dial pulse series to be measured, a voltage measurement with results in a value that depends on the line length, and, in accordance with this value, the times measured for pulse interval and pulse duration of the dial pulse series are corrected.