Abstract: Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 or 4; Y is independently --CONH--, --NHCO--, --OOC, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom, useful for the determination of haptens by immunochemical techniques are disclosed.

Abstract: A method for the determination of a partner in an immunochemical reaction, in which one of the partners, which is dissolved in an aqueous fluid, is allowed to react with the other partner, which is covalently bonded to a solid phase, which comprises allowing the reaction to take place in the presence of 0.1 to 3 g/100 g of the aqueous fluid of a surfactant of the formula ICH.sub.3 --(CH.sub.2).sub.m --R--(CH.sub.2 --CH.sub.2 --O).sub.n --HIin which R is O, NH or CH.dbd.CH--(CH.sub.2).sub.p --O with m being 3-26, n being 7-40 and p being 5-15, and an agent suitable for this purpose, are described.

Abstract: Dispersion polymers composed of a compound or of several compounds of the formula ICH.sub.2 .dbd.CR.sub.1 --CO--NH--(CH.sub.2).sub.n --CH(OR.sub.2)OR.sub.3Iin whichn is 1-6, andR.sub.1 is H or CH.sub.3 and R.sub.2 and R.sub.3 are identical or different and denote --(CH.sub.2).sub.m --CH.sub.3 with m denoting 0-7 or --C(X)(Y)Z with X, Y and Z denoting (CH.sub.2).sub.p CH.sub.3, and p denoting 1-3, where X, Y and Z can be identical or different, and, where appropriate, of another vinyl derivative or of other vinyl derivatives in an aqueous medium, a process for the preparation thereof, and the use thereof for the preparation of conjugates with biologically active substances are described.

Abstract: Dispersion polymers, processes for their preparation and their use are disclosed. The dispersion polymers being obtained by a seed polymerization process in the presence of seed latices with a high residual monomer content and a monomer mixture of at least one compound of the formula I ##STR1## wherein n=1-6;R.sub.1 =H or CH.sub.3 andR.sub.2 and R.sub.3 are identical or different, where R.sub.2 and R.sub.3 =--(CH.sub.2).sub.m --CH.sub.3, and m=0-7, or ##STR2## in which X, Y and Z=(CH.sub.2).sub.p --CH.sub.3 and p=1-3, where X, Y and Z are identical or different,or R.sub.2 and R.sub.3 =an aryl radical,and if appropriate acrylic acid, methacrylic acid, crotonic acid and monomers from which the seed latex is prepared. The invention furthermore relates to the biologically active latex conjugates which are obtained using the dispersion polymers and are particularly suitable for serological and immunological determination methods.

Abstract: The invention relates to dispersion polymers, processes for their preparation and their use, the dispersion polymers being obtained by a seed polymerization process in the presence of seed latices with a high residual monomer content and a monomer mixture of at least one compound of the formula I ##STR1## wherein n=1-6; R.sub.1 =H or CH.sub.3 andR.sub.2 and R.sub.3 are identical or different, whereR.sub.2 and R.sub.3 =-(CH.sub.2).sub.m -CH.sub.3, and m=0-7, or ##STR2## or R.sub.2 and R.sub.3 =an aryl radical, and if appropriate acrylic acid, methacrylic acid, crotonic acid and monomers from which the seed latex is prepared.The invention furthermore relates to the biologically active latex conjugates which are obtained using the dispersion polymers and are particularly suitable for serological and immunological determination methods.

Abstract: The invention relates to dispersion polymers, processes for their preparation, and their use, and also active dispersion polymers (latex conjugates) prepared therefrom, the dispersion polymers being obtained by polymerizing compounds of the formula IH.sub.2 C.dbd.C(R.sub.1)--CO--NH--(CH.sub.2).sub.n --CH(OR.sub.2)(OR.sub.3)Iin whichn denotes 1-6;R.sub.1 denotes H or CH.sub.3 andR.sub.2 and R.sub.3 are identical or different and denote --(CH.sub.2).sub.m --CH.sub.3,m denotes 0-7, or --CY(X)(Z), in which X, Y and Z denote (CH.sub.2).sub.p CH.sub.3 andp denotes 1-3, where X, Y and Z are identical or different,and compounds of the formula IIH.sub.2 C.dbd.C(R.sub.1)--CO--R--(CH.sub.2).sub.n --(CHOH).sub.m --(CH.sub.2).sub.l --H IIin whichR denotes O or NH;n denotes 1-3;m denotes 1-4;l denotes 0-4; andR.sub.1 denotes H or CH.sub.3,with one another in the presence of a seed dispersion, whereby the copolymer is formed on the surface of the latex particles.

Abstract: Dispersion polymers composed of latex, which have on the particle surface a copolymer composed of monomers having terminal acetals of the formula ICH.sub.2 .dbd.CR.sub.1 --CO--NH--(CH.sub.2).sub.n --CH(OR.sub.2) (OR.sub.3) Iin whichn=1-6;R.sub.1 =H or CH.sub.3, andR.sub.2 and R.sub.3 are identical or different withR.sub.2 and R.sub.3 =--(CH.sub.2).sub.m --CH.sub.3 (m=0-7) orR.sub.2 and R.sub.3 =--CXYZ, X, Y and Z being (CH.sub.2).sub.p --CH.sub.3 and p being 1-3, with X, Y, Z being identical or different,and betaine compounds of the formula IICH.sub.2 .dbd.CR--(CH.sub.2).sub.a --(CO--X).sub.b --Z--(CH.sub.2).sub.c --Y IIwithR=H or CH.sub.3,X=--NH or --0,Y=SO.sub.3.sup.- or COO.sup.- ##STR1## a=0-6, b=0-1,c=1-12,are very suitable for the preparation of biologically active latex reagents which have a particularly high detection sensitivity and stability.

Abstract: Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 to 4; Y is independently --CONH--, NHCO--, OOC--, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom are disclosed.

Abstract: A biologically active latex conjugate prepared by the acidification of latex particles of a core/shell polymer having acetal groups in the shell, whereby said acetal groups are converted to aldehyde groups, and then bonding a biologically active substance having an amino group to said aldehyde groups by reductive amination.

Abstract: What is disclosed is a latex, reactive with a biologically active substance to form a conjugate suitable for serological or immunological assay procedures, the particles of which latex comprises a polymer core and a shell thereover, said shell comprising a water insoluble monomer of the formula ##STR1## wherein R.sub.2 is H or CH.sub.3, n is 1 to 6, and R.sub.3 and R.sub.4 are alkyl, aryl, or same other group imparting water insolubility to said monomer.

Abstract: What is disclosed is an improved nephelometric method for detecting an antigen or antibody by contact thereof in a liquid medium with particles of a latex reagent comprising latex particles of different sizes loaded with different amounts of a corresponding antibody or antigen and then measuring the light scattered by a latex reagent.