Abstract: The invention relates to chromophoric peptides of the general formula I ##STR1## in which n represents 1 or 2, a porcess for their preparation, agents containing them and their use for determining DD-carboxypeptidases.

Abstract: What are disclosed are pentapeptides, useful for influencing the maturing of T-lymphocytes, of the formulaG--K--Q--X--MwhereinG is arginine, lysine, ornithine, or homoarginine, or is an unsubstituted or substituted .omega.-aminoalkanoyl, .omega.-guanidinoalkanoyl, or .omega.-dimethylaminoalkanoyl;K is a basic amino acid such as lysine, arginine, homoarginine, or ornithine;Q is L- or D-glutamic acid, d-aspartic acid, or D-.alpha.-aminoadipic acid;X is L-valine or L-isoleucine; andM is an L- or D-aminoacid having a hydrophobic side chain, or an ester or amide of such an acid.

Abstract: What are disclosed are a nonapeptide of the formula ##STR1## wherein D-Aad (OBu.sup.t) represents D-.alpha.-aminoadipic acid .delta.-tert. butyl ester, methods for making this peptide, pharmaceutical preparations containing this peptide, and methods for its use in increasing fertility or for contraception.

Abstract: What is disclosed is a method for the manufacture of LH-RH and LH-RH analogs, which comprises reacting Glu-His(DnP)-OH with the corresponding peptide having a free amino group and protected carboxy groups in a solvent as used in peptide chemistry and with the addition of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOObt) and a carbodiimide and then splitting off the Dnp-(2,4-dinitrophenyl) group. The new method greatly reduces the degree of histidine racemization. The invention also provides a new dipeptide, i.e. Glu-His(Dnp)-OH.

Abstract: Partially protected human insulin-A-chain suitable as intermediate for insulin synthesis and process for its manufacture by reacting the partially protected peptide fragment 6 to 26 of the insulin-A-chain with the peptide fragment 1 to 5 containing an N-terminal amino protective group capable of being split off by 5% strength trifluoroacetic acid in methylene chloride.

Abstract: A process for the preparation of cysteine-containing peptides by detachment of the S-trityl groups by means of trifluoroacetic acid, wherein S-trityl compounds of these peptides are treated with a mixture of a mercaptan and trifluoroacetic acid.

Abstract: A peptide with LH-RH-activity which is a LH-RH-peptide wherein Gly in 6-position is replaced by D-glutaminic-acid which may be N-substituted at the CO-NH.sub.2 moiety, wherein in 10-position Gly-NH.sub.2 may be replaced by a NH-alkyl or NH-cycloalkyl group and/or wherein the amino acids in 4-, 5-, 7- and/or 8-position may be replaced by other amino acids and a process for its manufacture.

Abstract: A process for the purification of secretin by chromatography on an alkylated dextran gel is disclosed, as is a method of its manufacture appropriate for preparing larger amounts of secretin.

Abstract: Pharmaceutical preparations containing an L-pyroglutamic acid amide, processes for their preparation and methods of treating psychotic diseases with them.

Abstract: A rotor, adapted for rotation at high speeds, has symmetrically arranged radial channels for receiving tubular containers of material to be evaluated such for example as samples of blood. The outer end of each radially extending container filled with the sample to be evaluated is placed against a resilient abutment at the rim of the rotor, and the inner end of the container is placed in a receiving groove in a clamping member having limited axial movement relative to the axis of rotation of the rotor. The length of each sample container is such that it fits fairly snugly between the abutment and the clamping member when at a slight inclination to the plane of rotation of the rotor (that is, a plane perpendicular to the axis of rotation) when the clamping member is in a loading position.

Abstract: The present invention relates to peptides having strong LH-RH/FSH-RH activity, wherein Gly in the 6-position is replaced by different substituted amino acids and in the 10-position there is glycinamide or glycine in the 10-position is replaced by a NH-alkyl group with 1-3 carbon atoms or a NH-cyclopropyl group. The invention relates as well to a process for manufacturing said peptides, and to pharmaceutical preparations containing said peptides.

Abstract: Peptides having LH-RH/FSH-RH activity useful for treatment of male and female sterility.

Abstract: Method of treating excessive fibrinolysis with a modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated by--(R)(R).sub.X W groups,wherein R is prolyl or ##EQU1## X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W is --OH, --NH.sub.2, --NHC.sub.2 H.sub.5, --OCH.sub.3, or --OC.sub.2 H.sub.5.

Abstract: Modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated by--(R)(R).sub.X W groups,Wherein R is prolyl or ##EQU1## X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W is --OH, --NH.sub.2, --NHC.sub.2 H.sub.5, --OCH.sub.3, or --OC.sub.2 H.sub.5. Method for making trypsin-callicrein inhibitor so modified by amidation.

Abstract: The invention relates to tripeptide amides containing pyroglutamine, proline and histidine as amino acids having anti-depressive activity and a process for their manufacture.