Abstract: This application describes methods of inhibiting APOL1 and treating APOL1-mediated kidney diseases comprising administering Compound I and/or a pharmaceutically acceptable salt thereof. The application also describes pharmaceutical compositions comprising Compound I and/or a pharmaceutically acceptable salt thereof.

Abstract: This application describes methods of inhibiting APOL1 and treating APOL1-mediated diseases comprising administering Compound I and/or a pharmaceutically acceptable salt thereof. The application also describes pharmaceutical compositions comprising Compound I and/or a pharmaceutically acceptable salt thereof.

Abstract: A transport container comprises two container components forming opposite side walls of the container for receiving opposite respective ends of tubular or rod-shaped workpieces. Each container component is in the shape of a half shell with a generally flat shell floor having first and second opposite edges and two opposite side edges, a circumferential shell wall open on the first edge, and foot supports extending from the shell wall at the second edge. Attachment elements are located on the side edges of the container components for attachment of tension devices for urging the container components towards each other.

Abstract: A current pass-through arrangement for a rodlike electrode passing substantially perpendicularly through a hot wall of a container features an inner seal and an outer seal, with the outer seal located at a substantially cooler position than the hot wall. Preferably, a portion of the electrode is tightly fitted into a cylindrical bushing of electrically insulating material. The electrode projects out of this bushing, at least at the container-adjacent end. In turn, the bushing is tightly fitted into a wall element (4) having a smaller-diameter end and a larger-diameter end which is sealed into the container wall. The wall element (4) and the electrode centered within it define an annular space which is at least partly filled with sealing material (5). According to a further embodiment, the electrode also projects from the container-remote end of the bushing (3).

Abstract: A process for manufacturing foamed silicone compositions by foaming a cross-linkable composition which comprises:(a) 100 parts by weight of a vinyl-containing polysiloxane containing 0.0002 to 3% by weight of vinyl groups and a viscosity of from 0.1 to 1,000 Pascal-seconds at 25.degree. C.,(b) up to 10 parts by weight of a silanol-containing silicon compound with a viscosity from 0.01 to 10 Pascal-seconds at 25.degree. C.,(c) up to 200 parts by weight of filler,(d) 1 to 50 parts by weight of a polysiloxane with a viscosity of 0.005 to 0.1 Pascal-seconds at 25.degree. C., and(e) a platinum catalyst, is characterized by foaming the cross-linkable composition with a substance containing hydroxyl groups at temperatures of 50.degree. to 150.degree. C.

Abstract: A pump for cryogenic liquids is provided with an enclosing vessel of the construction of a Dewar flask. A submerged multistage rotary pump is suspended from the mouth of the flask by means of a system providing thermal insulation opposing the flow of heat down the neck of the flask. The drive motor is coupled to the drive shaft of the immersion pump through a magnet coupling of which the elements are separated by a pressure seal. The latter and the extensive thermal insulation make the pump suitable for pumping liquid air or liquid nitrogen in a pressurized closed circuit and the presence of a supply of the cryogenic liquid around the pump itself makes it possible to start the pump at once after a quiescent period. A level-control sonde operates to assure that the presence of the necessary minimum of liquid in the vessel.

Abstract: A gas-cooled nuclear reactor, having a tight connection with an intentionally provided leak site between a fission-gas discharge channel formed in a reactor core carrying plate as well as in a head portion of encased fuel elements that are suspended in receiving bores formed in the core carrying plate, the tight connection being formed by an annular member having a sealing surface engaging the core carrying plate at a region thereof in which an opening to the fission-gas discharge channel formed in the core carrying plate is located, a gas-tight, elastic and substantially cylindrical member, variable in length, connecting the annular member to the fission-gas discharge channel formed in the head portion of the fuel element, compression spring means biasing the annular member in a direction away from the fission gas discharge channel formed in the fuel-element head portion, and a sealing abutment plate secured to a central pin and limiting clearance for play of the annular member with respect to an annular zon