Abstract: The invention relates to a cystic fibrosis transmembrane conductance regulator (CFTR) modulator for use in the prevention and/or treatment of diseases involving endothelial and/or epithelial barrier dysfunctions. The disease does not comprise cystic fibrosis. The invention further relates to a pharmaceutical composition comprising a CFTR modulator as an active ingredient for use in the prevention and/or treatment of diseases involving endothelial and/or epithelial barrier dysfunctions. The invention further relates to a kit of parts for use in the prevention and/or treatment of diseases involving endothelial and/or epithelial barrier dysfunctions comprising i) a CFTR modulator and ii) a further CFTR modulator. The invention further relates to a method of treating a condition, disease or disorder involving endothelial and/or epithelial barrier dysfunctions in a subject, the method comprising administering a CFTR modulator to a subject, preferably a mammal, in the need thereof.

Abstract: A process and device for noninvasive measurement of cerebral blood flow simultaneously determines of a blood flow index which is directly proportional to the blood flow. Cerebral surge kinetics of an intravenously injected indicator dye with absorption properties in the near-infrared spectrum is sensed by near-infrared spectroscopy and the arterial surge kinetics is sensed by pulse densitometry. A device for carrying out this process consists of a multichannel apparatus having at least two near-infrared spectroscopes, each having two pulsed monochromatic light sources, a measuring and a reference wavelength, in the range of the near-infrared spectrum; one or more light sensors connected to a photomultiplier; and a noninvasive measuring device which determines, by pulse densitometry, the concentration of the tracer in the arterial blood of the circulatory system.

Abstract: A process for the production of indole derivatives, which is characterized in that in the presence of phosphoric acid a substitution with an imine is performed, and intermediate products of this process and the production of these intermediate products are described.

Abstract: A process for the production of gramine derivatives is described, which is characterized in that an indole is reacted with an imine under acid catalysis in the presence of primary amines.

Abstract: Apparatus for ascertaining the upper level of oil or another liquid in a shallow or deep tank has a perforated vertical conduit which is installed in and extends to the bottom of the vessel. A vertical pipe is adjacent to the conduit and is sealed from the contents of the tank. The pipe contains electrical components which are connected to an indicating instrument and include a row of spaced-apart electric switches actuatable by a permanent magnet in a float which is movable up and down within the confines of the conduit so that the instrument receives signals denoting the actuated switch or switches and thus enables an attendant to ascertain the liquid level in the tank. The pipe and the conduit consist of several superimposed sections having flanges which are bolted or otherwise separably connected to each other to allow for convenient dismantling of the pipe and conduit and their transfer to storage or to another tank.

Abstract: An upright metallic pipe, which extends into the supply of liquid in a vessel adjacent to a conduit for a float with a permanent magnet which rises and falls with the upper level of liquid, contains an elongated flexible body having an impermeable insulating sheath and an insulating web in the sheath. The web carries a row of electric resistors and an adjacent row of electric switches which are connected with a level indicating instrument. The switches are actuated by the magnet to thereby change the number of resistors which are connected with the instrument. The flexible body can be withdrawn from the pipe and converted into a small package consisting of overlapping convolutions. Such conversion involves flexing the web in the regions between neighboring switches. Such regions are traversed by flexible conductors which connect the neighboring switches and/or resistors to each other.