Abstract: A method to provide therapeutic microvesicles from probiotic bacteria comprises exposing the bacteria to an inducing treatment during culturing to induce production of therapeutic microvesicles by the bacteria. The therapeutic microvesicles may be used in treatment of, for instance, colic, an infant or childhood gastrointestinal disorder or disease, a gastrointestinal pain disorder, a bone loss disease and/or a periodontal disease.

Abstract: A method to provide therapeutic microvesicles from probiotic bacteria comprises exposing the bacteria to an inducing treatment during culturing to induce production of therapeutic microvesicles by the bacteria. The therapeutic microvesicles may be used in treatment of, for instance, colic, an infant or childhood gastrointestinal disorder or disease, a gastrointestinal pain disorder, a bone loss disease and/or a periodontal disease.

Abstract: A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.

Abstract: The present embodiments relate to selection of agents effective in reducing or preventing gastrointestinal pain in a subject. Such an agent is selected and identified if it is capable of reducing spontaneous and/or induced transient receptor potential vanilloid 1 (TRPV1) activation.

Abstract: An exhaust hood includes a housing, which is open towards a bottom face to capture cooking by-products from a cooking appliance positioned below the exhaust hood. The housing has a first wall and a second wall opposite to the first wall. The second wall is at least partly inclined inwardly from the bottom face towards a top face of the housing and has an exhaust vent to extract cooking by-products captured by the housing. The exhaust hood has a fresh air fan and the first wall forms a first duct which has openings located in a row along a lower edge of the first wall adjacent to the bottom face and oriented inside the housing. A side wall extension extends from one side wall and forms a lateral skirt that defines a pass-through window having vertically and horizontally extending faces.

Abstract: A method to provide therapeutic microvesicles from probiotic bacteria comprises exposing the bacteria to an inducing treatment during culturing to induce production of therapeutic microvesicles by the bacteria. The therapeutic microvesicles may be used in treatment of, for instance, colic, an infant or childhood gastrointestinal disorder or disease, a gastrointestinal pain disorder, a bone loss disease and/or a periodontal disease.

Abstract: The present embodiments relate to selection of agents effective in reducing or preventing gastrointestinal pain in a subject. Such an agent is selected and identified if it is capable of reducing spontaneous and/or induced transient receptor potential vanilloid 1 (TRPV1) activation.

Abstract: The present embodiments relate to selection of agents effective in reducing or preventing gastrointestinal pain in a subject. Such an agent is selected and identified if it is capable of reducing spontaneous and/or induced transient receptor potential vanilloid 1 (TRPV1) activation.

Abstract: An exhaust hood includes a housing, which is open towards a bottom face to capture cooking by-products from a cooking appliance positioned below the exhaust hood. The housing has a first wall and a second wall opposite to the first wall. The second wall is at least partly inclined inwardly from the bottom face towards a top face of the housing and has an exhaust vent to extract cooking by-products captured by the housing. The exhaust hood has a fresh air fan and the first wall forms a first duct which has openings located in a row along a lower edge of the first wall adjacent to the bottom face and oriented inside the housing. A side wall extension extends from one side wall and forms a lateral skirt that defines a pass-through window having vertically and horizontally extending faces.

Abstract: An exhaust hood includes a housing, which is open towards a bottom face to capture cooking by-products from a cooking appliance positioned below the exhaust hood. The housing has at least a first wall and a second wall opposite to the first wall. The second wall is at least partly inclined inwardly from the bottom face towards a top face of the housing and has an exhaust vent that communicates with an exhaust fan to extract cooking by-products captured by the housing. The exhaust hood has a fresh air fan and the first wall is shaped to form a first duct which has a number of openings located in a row along a lower edge of the first wall adjacent to the bottom face and oriented to the inside of said housing. The first duct is in communication with the fresh air fan to inject air streams through the openings into the housing in a direction substantially parallel to the bottom face. This creates a vertical flat air stream directed from the first wall towards the second wall.

Abstract: A sheet metal bending machine comprises main bending tool assembly (2; 6) that extends along a longitudinal direction (A) and is movable so as to bend a workpiece (50), a guide (3) associated and parallel to the main bending tool assembly (2; 6), extending through a working zone (W) of the bending machine (1) and sideways protruding from the latter at least with a first end portion (4), and shuttles (21, 22, 23) slidably mounted on said guide (3) and supporting at least one auxiliary tool (41, 42) to be associated with the main bending tool assembly (2; 6) in order to execute partial bends on the workpiece (50); the shuttles (21, 22, 23) are movable along the longitudinal direction (A) between a first active position (P1), in which the shuttle (21, 22, 23) are inside the working zone (W) and the auxiliary tool (41, 42) is mounted on the main bending tool assembly (2; 6), and a first inactive position (R1), in which the shuttle (21, 22, 23) are outside the working zone (W) and positioned at the first end porti

Abstract: Vagus nerve stimulation effective in treating mood disorders include application of bursts of vagus nerve stimulation pulses having an average inter-burst duration and an average inter-pulse duration within selected intervals. The effectiveness of test agents in treating mood disorders can be determined by monitoring the firing pattern induced by the test agents on the vagus nerve. Test agents capable of inducing a firing pattern of vagus nerve pulses with average inter-burst duration and average inter-pulse duration within the selected intervals are identified as useful in treating a mood disorder.

Abstract: An exhaust hood includes a housing, which is open towards a bottom face to capture cooking by-products from a cooking appliance positioned below the exhaust hood. The housing has at least a first wall and a second wall opposite to the first wall. The second wall is at least partly inclined inwardly from the bottom face towards a top face of the housing and has an exhaust vent that communicates with an exhaust fan to extract cooking by-products captured by the housing. The exhaust hood has a fresh air fan and the first wall is shaped to form a first duct which has a number of openings located in a row along a lower edge of the first wall adjacent to the bottom face and oriented to the inside of said housing. The first duct is in communication with the fresh air fan to inject air streams through the openings into the housing in a direction substantially parallel to the bottom face. This creates a vertical flat air stream directed from the first wall towards the second wall.

Abstract: A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.

Abstract: A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein the method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyze the effect of the agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyze the effect of the agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of the bacterial strains in the treatment of intestinal motility disorders are also provided.

Abstract: The present embodiments relate to selection of agents effective in reducing or preventing gastrointestinal pain in a subject. Such an agent is selected and identified if it is capable of reducing spontaneous and/or induced transient receptor potential vanilloid 1 (TRPV1) activation.

Abstract: A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.

Abstract: A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, comprising: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyze the effect of the agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyze the effect of the agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of the bacterial strains in the treatment of intestinal motility disorders are also provided.

Abstract: A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.

Abstract: A sheet metal bending machine comprises main bending tool assembly (2; 6) that extends along a longitudinal direction (A) and is movable so as to bend a workpiece (50), a guide (3) associated and parallel to the main bending tool assembly (2; 6), extending through a working zone (W) of the bending machine (1) and sideways protruding from the latter at least with a first end portion (4), and shuttles (21, 22, 23) slidably mounted on said guide (3) and supporting at least one auxiliary tool (41, 42) to be associated with the main bending tool assembly (2; 6) in order to execute partial bends on the workpiece (50); the shuttles (21, 22, 23) are movable along the longitudinal direction (A) between a first active position (P1), in which the shuttle (21, 22, 23) are inside the working zone (W) and the auxiliary tool (41, 42) is mounted on the main bending tool assembly (2; 6), and a first inactive position (R1), in which the shuttle (21, 22, 23) are outside the working zone (W) and positioned at the first end porti