Abstract: The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

Abstract: The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein Rx, Ry, Rz and Rzz are selected from: a) Rx and Ry are F and Rz and Rzz are H; b) Rx, Ry and Rzz are independently halogen and Rz is H; c) Rx Rz and Rzz are independently halogen and Ry is H; and d) Rx Ry and Rz are independently halogen and Rzz is H.

Abstract: A diagonal fan wheel (1) has a cover disk (2) and a bottom disk (3). A plurality of three-dimensionally curved blades (S) are arranged between the cover disk (2) and bottom disk (3). The blades (S) are connected to the cover disk (2) and bottom disk (3) in a materially bonded manner.

Abstract: The invention relates to an orbital pump for pumping a fluid, wherein the pump comprises at least one pump control system, a motor that can be controlled by the pump control system, a rotor shaft (10) for fluid transport, and a rotor sensor for detecting an absolute angle of rotation of the rotor shaft (40), the rotor sensor is connected to the pump control system and designed to transmit the angle of rotation of the rotor shaft (40) to the pump control system, and the pump control system is designed to rotationally control the rotor shaft (40) by means of the motor until the rotor shaft (40) is in a pre-determined angle of rotation position.

Abstract: The invention relates to a housing, wherein the housing has a cover disk having a cylindrical wall and a central receptacle with a hub for supporting a fan having a diagonal fan wheel, wherein a plurality of three-dimensionally curved air guide vanes (S) are arranged about the hub, characterized in that the air guide vanes (S) are materially connected to the cylindrical wall and as a result, the housing is produced in one working step.

Abstract: An axial ventilator (1) has a housing (2) and a fan wheel (3) arranged in the housing (2) to generate an axial air flow through the housing (2). The fan wheel (3) has multiple fan wheel blades (4) that extend radially outward from a hub (5) up to a respective blade tip (8). The blades extend spaced apart from an inner wall of the housing (2) via a head gap (12). The fan wheel blades (4) have boreholes (7) along the respective blade tip (8).

Abstract: A set of parts for a radial fan has a fan wheel (2), a main housing part (1), and a complementary housing part (3). They can be assembled to form a first housing that encloses the fan wheel (2). The housing has an inlet opening (27) and an outlet (23). At least one second complementary fan wheels (2?, 2?) (3?, 3?), the shape of which differs from the first fan wheel part (2), can be connected to the motor instead of the fan wheel (2).

Abstract: A pump device (10) for pumping a fluid, having a hydraulic enclosure (12) that comprises an annular section, a pump ring (14) that is deformable and which defines an annular pump chamber at least in certain regions, a pump ring carrier (16) that is solidly connected to the pump ring (14), a first connector and a second connector, which first connector and which second connector are in fluid communication with the pump chamber, wherein the pump device (10) is set up in such a way that at least one measure influences a parking position of an eccentric (18) such that said parking position is preferred in the region of a clamping member (114), the measure being selected from: a) at least one recess in the hydraulic housing, which recess locally widens the chamber for the pump ring (14) in the axial direction, b) a geometry of the pump ring carrier (16), in which the pump ring carrier (16) has an enlarged diameter on its inner side facing the eccentric (18) in the angular region of the clamping member (114), and c

Abstract: A housing (17) of a fan (1) has an inflow-side end surface (2), an outflow-side end surface (16), and a wall ring (15). The wall ring 15 extends in a direction of an axis (12) from one of the end surfaces (2) to the other (16) and adjoins a fan passage. A fan wheel (10) is arranged in the fan passage. A grid (3) is arranged on the inflow-side end surface (2). The grid has a hub (8) positioned centrally in the fan passage. Primary struts (4) extend in the radial direction between the hub (8) and the edge of the fan passage. Secondary struts (6) intersect the primary struts (4).

Abstract: The invention relates to a housing, wherein the housing has a cover disk having a cylindrical wall and a central receptacle with a hub for supporting a fan having a diagonal fan wheel, wherein a plurality of three-dimensionally curved air guide vanes (S) are arranged about the hub, characterized in that the air guide vanes (S) are materially connected to the cylindrical wall and as a result, the housing is produced in one working step.

Abstract: A diagonal fan wheel (1) has a cover disk (2) and a bottom disk (3). A plurality of three-dimensionally curved blades (S) are arranged between the cover disk (2) and bottom disk (3). The blades (S) are connected to the cover disk (2) and bottom disk (3) in a materially bonded manner.

Abstract: The invention relates to an orbital pump for pumping a fluid, wherein the pump comprises at least one pump control system, a motor that can be controlled by the pump control system, a rotor shaft (10) for fluid transport, and a rotor sensor for detecting an absolute angle of rotation of the rotor shaft (40), the rotor sensor is connected to the pump control system and designed to transmit the angle of rotation of the rotor shaft (40) to the pump control system, and the pump control system is designed to rotationally control the rotor shaft (40) by means of the motor until the rotor shaft (40) is in a pre-determined angle of rotation position.

Abstract: A fan comprising a fan wheel with impeller hub and impeller blades, and electric motor with a stator and rotor that can rotate about rotation axis (RA) and has a rotor bell comprising an axially front-side rotor bell base. Impeller hub is fastened to the rotor bell wherein, in the rotor bell base, at least one aperture ensures a cooling air flow from the rotor bell. Fan comprises a cover plate arranged on the rotor bell base with a central opening, wherein cover plate covers at least one aperture of the rotor bell base axially spaced at least in sections, so that between the rotor bell base and an inner surface of the cover plate a radially inward extending flow channel toward the central opening of the cover plate is formed. The cover plate radially outward comprises an inclined or curved course in the direction of the rotor bell base.

Abstract: An axial ventilator (1) has a housing (2) and a fan wheel (3) arranged in the housing (2) to generate an axial air flow through the housing (2). The fan wheel (3) has multiple fan wheel blades (4) that extend radially outward from a hub (5) up to a respective blade tip (8). The blades extend spaced apart from an inner wall of the housing (2) via a head gap (12). The fan wheel blades (4) have boreholes (7) along the respective blade tip (8).

Abstract: A set of parts for a radial fan has a fan wheel (2), a main housing part (1), and a complementary housing part (3). They can be assembled to form a first housing that encloses the fan wheel (2). The housing has an inlet opening (27) and an outlet (23). At least one second complementary fan wheels (2?, 2?) (3?, 3?), the shape of which differs from the first fan wheel part (2), can be connected to the motor instead of the fan wheel (2).

Abstract: A housing (17) of a fan (1) has an inflow-side end surface (2), an outflow-side end surface (16), and a wall ring (15). The wall ring 15 extends in a direction of an axis (12) from one of the end surfaces (2) to the other (16) and adjoins a fan passage. A fan wheel (10) is arranged in the fan passage. A grid (3) is arranged on the inflow-side end surface (2). The grid has a hub (8) positioned centrally in the fan passage. Primary struts (4) extend in the radial direction between the hub (8) and the edge of the fan passage. Secondary struts (6) intersect the primary struts (4).