Patents by Inventor Wolfgang Meschendoerfer

Wolfgang Meschendoerfer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPR-based dual-binding assay for the functional analysis of multispecific molecules
    Publication number: 20230236178
    Abstract: Herein is reported a method for determining the binding of an antibody, which comprises a first binding site specifically binding to a first antigen and a second binding site specifically binding to a second antigen, to said first and said second antigen, wherein the method comprises the steps of capturing the antibody on a solid phase using a capture reagent specifically binding to a constant domain of the antibody, incubating the captured antibody with the first or the second antigen to form a captured antibody-antigen complex and determining a first binding signal, either i) incubating the captured antibody-antigen complex with the antigen not used for the formation of the captured antibody-antigen complex to form a captured antibody-antigen-antigen complex and determining a second binding signal, or ii) regenerating the surface, capturing the antibody on a solid phase using a capture reagent specifically binding to a constant domain of the antibody, incubating the captured antibody with the antigen not us
    Type: Application
    Filed: August 22, 2022
    Publication date: July 27, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian Gassner, Wolfgang Meschendoerfer, Joerg Moelleken
  • SPR-based dual-binding assay for the functional analysis of multispecific molecules
    Publication number: 20190317086
    Abstract: Herein is reported a method for determining the binding of an antibody, which comprises a first binding site specifically binding to a first antigen and a second binding site specifically binding to a second antigen, to said first and said second antigen, wherein the method comprises the steps of capturing the antibody on a solid phase using a capture reagent specifically binding to a constant domain of the antibody, incubating the captured antibody with the first or the second antigen to form a captured antibody-antigen complex and determining a first binding signal, either i) incubating the captured antibody-antigen complex with the antigen not used for the formation of the captured antibody-antigen complex to form a captured antibody-antigen-antigen complex and determining a second binding signal, or ii) regenerating the surface, capturing the antibody on a solid phase using a capture reagent specifically binding to a constant domain of the antibody, incubating the captured antibody with the antigen not us
    Type: Application
    Filed: March 27, 2019
    Publication date: October 17, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian Gassner, Wolfgang Meschendoerfer, Joerg Moelleken