Abstract: A method of producing thrombin from Factor II (prothrombin) comprising the steps of:a) applying a solution of citrated plasma or citrated plasma fraction containing Factor II onto an equilibrated anion exchanger to bind Factor II thereto;b) applying a solution containing calcium ions to the exchanger to convert the Factor II to thrombin, andc) selectively eluting the thrombin from the carrier.

Abstract: Process for the preparation of an immunoglobulin solution suitable for intravenous administration from a human blood protein fraction containing immunoglobulins IgG, IgA and IgM in partially concentrated from, with the process steps: addition of acetate buffer to the protein fraction, where appropriate removal of insoluble constituents by filtration, treatment with calcium phosphate and octanoic acid, centrifugation, removal of the supernatant and treatment thereof with an adsorbent, removal of the adsorbent and sterilization by filtration.

Abstract: A method of enrichment of coagulation Factors II, VII, IX and X in preparations obtained from plasma, plasma fractions, or other liquids containing the factors, by adsorbing the factor or factors onto a polymeric matrix that carries an .alpha.-hydroxylamine group, and eluting the factors. When the chromatography conditions are appropriate, it is also easy to prepare a highly concentrated Factor IX preparation with a purity of more than 10 U per mg of protein.

Abstract: A method of isolating blood-clotting Factor IX. A solution containing the Factor IX is adsorbed onto an adsorbent carrying .alpha.-hydroxylamine groups, and the factor is eluted. The Factor IX from the eluate is adsorbed onto a matrix carrying sulfated carbohydrates, with the conductivity adjusted to 13-17 mS/cm, and eluted with a salt gradient. The pure Factor IX is concentrated and freeze-dried.

Abstract: To provide a simple method of preparing biologically active transferrin that can be employed on an industrial scale and that will result in extremely pure and natural transferrin containing no viruses and appropriate for both in-vitro and in-vivo applications, the .gamma.-globulins are precipitated from the fraction containing the transferrin, the precipitant is removed from the residual liquid by ultrafiltration or gel filtration, the liquid is adjusted to a prescribed ionic concentration and protein concentration and (a) treated with .beta.-propiolactone and the solution is subjected to ultraviolet radiation or (b) treated with specific detergents and subjected to ion-exchange chromatography, and the transferrin is concentrated and filtered sterile.

Abstract: A method of sterilizing plasma or plasma fractions, including fractions that contain the blood-coagulating Factor VIII by treatment with .beta.-propiolactone or ultraviolet radiation. Treatment with tri-n-butyl phosphate and sodium cholate or Tween 80 is carried out either prior to or simultaneously with the .beta.-propiolactone treatment or ultraviolet radiation.

Abstract: The invention relates to an apparatus for gaining boneless fish fillets. In a fish filleting machine which processes the fish being conveyed tail first and comprises a belly and back filleting toot, and a severing tool for releasing meat bands on either side of the spinal column in the tail region, a pinbone tool is arranged between the two first-mentioned tools, this pinbone tool comprising circular knives between which a graving knife is arranged for severing the meat strip containing the pinbones immediately after this strip has been cut free.

Abstract: An axial thrust bearing includes a plurality of circumferentially arranged segments. The segments are constrained in the circumferential direction by means of support plates disposed therebetween. The segments are elastically supported by means of individual spring elements mounted in a bearing body. The segments are provided with support ribs having tilting edges. The support ribs are supported between the support plates, and the tilting edges are supported against the spring elements. As a result, friction between the segments is minimized.