Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A system and method for creating secure software code. Original code is processed to determine memory states, which are dynamic during execution of the code. Selected functions of the code are duplicated and placed in parallel alternative control paths in order to create protected code with increased path diversity. The state of the memory, or a variable derived therefrom is used to select one of the alternative paths during execution of the protected code.

Abstract: The present invention is inter alia directed to compositions comprising at least one nucleic acid encoding at least one antigenic peptide or protein selected or derived from a Coronavirus membrane protein (M), nucleocapsid protein (N), non-structural protein, and/or accessory protein or an immunogenic fragment or immunogenic variant thereof. The composition may additionally comprise at least one nucleic acid encoding at least one antigenic peptide or protein selected or derived from a Coronavirus spike protein (S). The nucleic acid sequences of the compositions are preferably in association with a polymeric carrier, a polycationic protein or peptide, or a lipid nanoparticle (LNP). The compositions provided herein are for use in treatment or prophylaxis of an infection with at least one Coronavirus, and may therefore be comprised in a vaccine, preferably a multivalent vaccine.

Abstract: A wearable element is disclosed. In an embodiment a wearable element includes at least one piezoelectric element configured to vibrate so that a haptic impression of an acoustic signal is generated, wherein the wearable element is wearable on a body.

Abstract: The present disclosure relates to a separating device for removing solid particles from fluids, and to the use of said separating device for removing solid particles from fluids.

Abstract: A wearable element is disclosed. In an embodiment a wearable element includes at least one piezoelectric element configured to vibrate so that a haptic impression of an acoustic signal is generated, wherein the wearable element is wearable on a body.