Patents by Inventor Wolfgang Scholz

Wolfgang Scholz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11911566
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: February 27, 2024
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
  • Publication number: 20240014104
    Abstract: A semiconductor package comprises a semiconductor transistor circuit comprising a semiconductor transistor die comprising die terminals, including a collector/drain, a source/emitter, a sense source/sense emitter, a gate, and a load path, a driver line connected with the gate, and a gate control loop in which the a sense source/sense emitter is connected with the driver line, a plurality of external contacts comprising at least one first external contact connected with the drain/collector, at least one second external contact connected with the source/emitter, a third external contact connected with the a sense source/sense emitter, and a fourth external contact connected with the gate, wherein the plurality of external contacts are arranged or configured to reduce or utilize the magnetic coupling induced by a load current flowing through the load path.
    Type: Application
    Filed: June 30, 2023
    Publication date: January 11, 2024
    Inventors: Edward Fürgut, Wolfgang Scholz, Christian Baeumler, Thomas Basler, Xing Liu, Bernd Schmoelzer
  • Patent number: 11833309
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: December 5, 2023
    Assignee: Third Pole, Inc.
    Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
  • Patent number: 11827989
    Abstract: System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: November 28, 2023
    Assignee: Third Pole, Inc.
    Inventors: Philip E. Silkoff, Gregory W. Hall, Wolfgang Scholz
  • Publication number: 20230365707
    Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.
    Type: Application
    Filed: April 14, 2023
    Publication date: November 16, 2023
    Inventors: Ritsuko Sawada, Shu-Man Sun, Wolfgang Scholz
  • Publication number: 20230360929
    Abstract: A method for fabricating a semiconductor device module includes: providing a first encapsulant layer and a core layer disposed on the first encapsulant layer, the core layer having an opening; disposing a semiconductor device in the opening, the semiconductor device having a die carrier and a semiconductor die disposed on the die carrier; dispensing an encapsulant onto the semiconductor device; applying a second polymer layer onto the encapsulant so that the encapsulant is pressed into the opening; and laminating together the first and second encapsulant layers and the encapsulant.
    Type: Application
    Filed: April 28, 2023
    Publication date: November 9, 2023
    Inventors: Bernd Schmoelzer, Wolfgang Scholz, Ivan Nikitin, Edward Fürgut
  • Publication number: 20230330359
    Abstract: Systems and methods for delivering a gas, such as nitric oxide, are provided. In some embodiments, systems and methods are provided for delivering a gas, such as nitric oxide, in the form of nanobubbles and/or a dissolved gas using a liquid medium.
    Type: Application
    Filed: April 14, 2023
    Publication date: October 19, 2023
    Applicant: Third Pole, Inc.
    Inventors: Wolfgang Scholz, Gregory W. Hall, Jacob Naroian
  • Patent number: 11760809
    Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against disialoganglioside-GD2. The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to GD2. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: September 19, 2023
    Assignee: BioNTech SE
    Inventors: Wolfgang Scholz, Ritsuko Sawada
  • Publication number: 20230282591
    Abstract: A semiconductor package includes: a die carrier having a first main face and a second main face opposite to the first main face; a semiconductor die disposed on the die carrier, the semiconductor die including a first pad and a second pad; a first electrical connector disposed on the first pad; an encapsulant at least partially covering the semiconductor die, the die carrier, and the first electrical connector; and an insulation layer disposed on the second main face of the die carrier.
    Type: Application
    Filed: February 27, 2023
    Publication date: September 7, 2023
    Inventors: Edward Fürgut, Ivan Nikitin, Annette Fälschle, Wolfgang Scholz, Bernd Schmoelzer
  • Publication number: 20230263986
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Application
    Filed: December 13, 2022
    Publication date: August 24, 2023
    Applicant: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
  • Patent number: 11691879
    Abstract: Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NO2 from the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: July 4, 2023
    Assignee: Third Pole, Inc.
    Inventors: Vineel Kondiboyina, Christopher Miles, Gregory W. Hall, Simon E. Kozin, Wolfgang Scholz, Frank Heirtzler
  • Publication number: 20230158261
    Abstract: Systems and methods are provided related to signal conditioning and analysis methods for detecting respiratory events of a human or an animal. Respiratory events detected can either serve as input to a drug delivery system or be a stand-alone breath detection device. Various methods for sensing respiratory events, processing respiratory signals, and analyzing respiratory signals are provided with the goal of enabling accurate and reliable detection of specific types of events in a respiratory cycle.
    Type: Application
    Filed: November 18, 2022
    Publication date: May 25, 2023
    Applicant: Third Pole, Inc.
    Inventors: Fernando Trias, Wolfgang Scholz, Gregory W. Hall
  • Publication number: 20230149656
    Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.
    Type: Application
    Filed: October 24, 2022
    Publication date: May 18, 2023
    Applicant: Third Pole, Inc.
    Inventors: Gregory W. Hall, Ian J. Gillerman, Sina Mohsenian, Aubrey Ortiz, Christopher Miles, Wolfgang Scholz, Adam J. Young, Benjamin Apollonio, Ziad F. Elghazzawi
  • Publication number: 20230106642
    Abstract: A semiconductor assembly includes a laminate substrate that includes a plurality of laminate layers of electrically insulating material stacked on top of one another, a semiconductor package that includes a package body of electrically insulating encapsulant material and a plurality of electrical contacts that are exposed from the package body, wherein the semiconductor package is embedded within the laminate layers of the laminate substrate, wherein the semiconductor package comprises a delamination mitigation feature, wherein the delamination mitigation feature comprises one or both of a macrostructure that engages with the laminate layers, and a roughened surface of microstructures that enhances adhesion between the semiconductor package and the laminate layers.
    Type: Application
    Filed: September 20, 2021
    Publication date: April 6, 2023
    Inventors: Bernd Schmoelzer, Edward Fuergut, Ivan Nikitin, Wolfgang Scholz
  • Publication number: 20230098706
    Abstract: Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.
    Type: Application
    Filed: September 23, 2022
    Publication date: March 30, 2023
    Applicant: Third Pole, Inc.
    Inventors: Christopher Miles, Frank Heirtzler, Gregory W. Hall, Sweta Patel, Wolfgang Scholz
  • Patent number: 11554240
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: January 17, 2023
    Assignee: Third Pole, Inc.
    Inventors: Gregory W. Hall, Kevin Cedrone, Philip E. Silkoff, Wolfgang Scholz
  • Patent number: 11524134
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: December 13, 2022
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
  • Publication number: 20220339391
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 27, 2022
    Applicant: Third Pole, Inc.
    Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
  • Patent number: 11478601
    Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: October 25, 2022
    Assignee: Third Pole, Inc.
    Inventors: Gregory W. Hall, Ian J. Gillerman, Sina Mohsenian, Aubrey Ortiz, Christopher Miles, Wolfgang Scholz, Adam J. Young, Benjamin Apollonio, Ziad F. Elghazzawi
  • Publication number: 20220298653
    Abstract: System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.
    Type: Application
    Filed: June 10, 2022
    Publication date: September 22, 2022
    Applicant: Third Pole, Inc.
    Inventors: Philip E. Silkoff, Gregory W. Hall, Wolfgang Scholz