Patents by Inventor Wolfgang Scholz

Wolfgang Scholz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200247900
    Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.
    Type: Application
    Filed: February 11, 2020
    Publication date: August 6, 2020
    Inventors: Ritsuko Sawada, Shu-Man Sun, Wolfgang Scholz
  • Patent number: 10695523
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: June 30, 2020
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Ian J. Gillerman
  • Patent number: 10668198
    Abstract: A blood treatment apparatus having an extracorporeal circuit has a dialyzate circuit with a dialyzer, having a blood-side chamber, and a dialyzate-side chamber separated from the blood-side chamber by a membrane. The blood-side chamber is in fluid communication with the extracorporeal circuit and the dialyzate-side chamber is in fluid communication with the dialyzate circuit, and the apparatus has a preparation unit for online preparation of a solution. The apparatus has a first means for carrying out a priming mode and a second means for carrying out an initial treatment mode. The first means is configured to control the preparation unit to prepare a flushing solution having a pH of ?7.3, with the extracorporeal circuit being filled with the flushing solution. The second means is configured to control the preparation unit to prepare the dialyzate having a pH of ?7.3, with the dialyzate circuit being filled with the dialyzate.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: June 2, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Ursula Kreuzberg, Cacilia Scholz, Stefano Stuard, Wolfgang Wehmeyer
  • Publication number: 20200139072
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Application
    Filed: December 21, 2019
    Publication date: May 7, 2020
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
  • Publication number: 20200094011
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 26, 2020
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Ian J. Gillerman
  • Patent number: 10576239
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 3, 2020
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
  • Patent number: 10532176
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: January 14, 2020
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz
  • Publication number: 20200013723
    Abstract: A silicon carbide device includes a silicon carbide substrate, a contact layer including nickel, silicon and aluminum, a barrier layer structure including titanium and tungsten, and a metallization layer including copper. The contact layer is located on the silicon carbide substrate. The contact layer is located between the silicon carbide substrate and at least a part of the barrier layer structure. The barrier layer structure is located between the silicon carbide substrate and the metallization layer.
    Type: Application
    Filed: June 26, 2019
    Publication date: January 9, 2020
    Inventors: Edward Fuergut, Ravi Keshav Joshi, Ralf Siemieniec, Thomas Basler, Martin Gruber, Jochen Hilsenbeck, Dethard Peters, Roland Rupp, Wolfgang Scholz
  • Publication number: 20190314596
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Application
    Filed: April 18, 2019
    Publication date: October 17, 2019
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz
  • Patent number: 10373895
    Abstract: A semiconductor device includes a first lead frame, a second lead frame, a first semiconductor chip, and an encapsulation material. The first lead frame includes a first die pad having a first surface and a second surface opposite to the first surface. The second lead frame includes a second die pad having a first surface and a second surface opposite to the first surface. The first surface of the second die pad faces the first surface of the first die pad. The first semiconductor chip is attached to the first surface of the first die pad. The encapsulation material encapsulates the first semiconductor chip and portions of the first lead frame and the second lead frame. The encapsulation material has a first surface aligned with the second surface of the first die pad and a second surface aligned with the second surface of the second die pad.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: August 6, 2019
    Assignee: Infineon Technologies Austria AG
    Inventors: Edward Fuergut, Martin Gruber, Wolfgang Scholz, Ralf Otremba
  • Patent number: 10363788
    Abstract: A vibration damper is provided for a vehicle, preferably for a motor vehicle, having a wheel carrier made of metal for rotatably receiving a wheel, a damper tube arrangement at least partly made of a fiber-reinforced plastic for forming a damper fluid volume, a piston which is guided in the damper tube arrangement and includes a piston rod. The damper tube arrangement is rigidly connected to the wheel carrier and the piston rod can be connected to a body of the vehicle. A wheel carrier fluid volume is formed in the wheel carrier and which is connected to the damper fluid volume. The fluid in the wheel carrier fluid volume is in direct contact with the metal of the wheel carrier in order to transfer heat.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: July 30, 2019
    Assignee: Bayerische Motoren Werke Aktiengesellschaft
    Inventors: Andreas Reiser, Thomas Eifflaender, Michael Keigler, Johann Dudkowiak, Wolfgang Gruber, Matthias Stangl, Hubert Scholz, Thomas Kaespaizer, Martin Schwab
  • Publication number: 20190217042
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Application
    Filed: March 25, 2019
    Publication date: July 18, 2019
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler
  • Patent number: 10328228
    Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: June 25, 2019
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler
  • Patent number: 10292949
    Abstract: The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or neuropathy. Another object of the invention concerns the use of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the enhancement of insulin sensitivity and the preservation or increase of ß-cell compensation.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: May 21, 2019
    Assignee: Meck Patent GmbH
    Inventors: Norbert Beier, Wolfgang Scholz, Ulrich Betz, Marian Braendle
  • Patent number: 10286176
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: May 14, 2019
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz
  • Patent number: 10170497
    Abstract: According to various embodiments, an electronic device may include a carrier including at least a first region and a second region being laterally adjacent to each other; an electrically insulating structure arranged in the first region of the carrier, wherein the second region of the carrier is free of the electrically insulating structure; a first electronic component arranged in the first region of the carrier over the electrically insulating structure; a second electronic component arranged in the second region of the carrier; wherein the electrically insulating structure includes one or more hollow chambers, wherein the sidewalls of the one or more hollow chambers are covered with an electrically insulating material.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: January 1, 2019
    Inventors: Thoralf Kautzsch, Alessia Scire, Steffen Bieselt, Franz Hirler, Anton Mauder, Wolfgang Scholz, Hans-Joachim Schulze, Francisco Javier Santos Rodriguez
  • Publication number: 20180346597
    Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against disialoganglioside-GD2. The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to GD2. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.
    Type: Application
    Filed: December 12, 2017
    Publication date: December 6, 2018
    Inventors: Wolfgang SCHOLZ, Ritsuko SAWADA
  • Publication number: 20180243527
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system comprises a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Application
    Filed: February 27, 2018
    Publication date: August 30, 2018
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz
  • Publication number: 20180243528
    Abstract: The present disclosure relates to systems and methods for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
    Type: Application
    Filed: February 27, 2018
    Publication date: August 30, 2018
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler
  • Publication number: 20180175069
    Abstract: According to various embodiments, an electronic device may include a carrier including at least a first region and a second region being laterally adjacent to each other; an electrically insulating structure arranged in the first region of the carrier, wherein the second region of the carrier is free of the electrically insulating structure; a first electronic component arranged in the first region of the carrier over the electrically insulating structure; a second electronic component arranged in the second region of the carrier; wherein the electrically insulating structure includes one or more hollow chambers, wherein the sidewalls of the one or more hollow chambers are covered with an electrically insulating material.
    Type: Application
    Filed: February 20, 2018
    Publication date: June 21, 2018
    Inventors: Thoralf Kautzsch, Alessia Scire, Steffen Bieselt, Franz Hirler, Anton Mauder, Wolfgang Scholz, Hans-Joachim Schulze, Francisco Javier Santos Rodriguez