Patents by Inventor Wolfgang Simm

Wolfgang Simm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7534576
    Abstract: A Method for identifying one or a small number of molecules, especially in a dilution of ?1 ?M, using laser excited FCS with measuring times ?500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ?10?14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined. The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably ?1.2 N.A.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: May 19, 2009
    Assignee: Olympus Corporation
    Inventors: Rudolf Rigler, Manfred Eigen, Karsten Henco, Ulo Mets, Jerker Widengren, Michael Stuke, Michael Brinkmeyer, Wolfgang Simm, Olaf Lehman
  • Publication number: 20070243525
    Abstract: A Method for identifying one or a small number of molecules, especially in a dilution of ?1 ?M, using laser excited FCS with measuring times ?500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ?10?14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined. The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably ?1.2 N.A.
    Type: Application
    Filed: April 4, 2007
    Publication date: October 18, 2007
    Inventors: Rudolf Rigler, Manfred Eigen, Karsten Henco, Ulo Mets, Jerker Widengren, Michael Stuke, Michael Brinkmeyer, Wolfgang Simm, Olaf Lehmann
  • Patent number: 7241569
    Abstract: A Method for identifying one or a small number of molecules, especially in a dilution of ?1 ?M, using laser excited FCS with measuring times ?500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ?10?14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined. The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably ?1.2 N.A.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: July 10, 2007
    Assignee: Olympus Corporation
    Inventors: Rudolf Rigler, Manfred Eigen, Karsten Henco, Ulo Mets, Jerker Widengren, Michael Stuke, Michael Brinkmeyer, Wolfgang Simm, Olaf Lehman
  • Publication number: 20040142386
    Abstract: A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 &mgr;M, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.
    Type: Application
    Filed: May 12, 2003
    Publication date: July 22, 2004
    Applicant: EVOTEC Biosystems GmbH
    Inventors: Rudolf Rigler, Manfrea Eigen, Karsten Henco, Ulo Mets, Jerker Widengren, Michael Stuke, Michael Brinkmeyer, Wolfgang Simm, Olaf Lehman
  • Patent number: 6582903
    Abstract: A method for identifying one or a small number of molecules, especially in a dilution of ≦1 &mgr;M, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: June 24, 2003
    Assignee: Evotec OAI AG
    Inventors: Rudolf Rigler, Manfred Eigen, Karsten Henco, Ulo Mets, Jerker Widengren, Michael Stuke, Michael Brinkmeyer, Wolfgang Simm, Olaf Lehmann
  • Patent number: 5582665
    Abstract: A plate having wells therein for receiving chemical substances is provided with a coverplate covering said filled wells. The process for sealing the wells by providing a joining seam running around the wells provides the joining seam such that it has a profiled cross-section in order to increase the contact surface between the plate and the coverplate. To this end a welding die has a front surface provided with projecting profiled regions and being heated to a temperature in the region of the melting point of the coverplate. The welding die is placed on the coverplate means and remains there for a fixed first period. Then the welding die is pressed down through a fixed path and remains in this position for a fixed second period. Removing the welding die from the coverplate is the last step in the process.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: December 10, 1996
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Manfred Eigen, Wolfgang Simm
  • Patent number: 5447679
    Abstract: A process serves for producing a plate comprising at least one well having ts opening facing upwards, for receiving chemical and/or biochemical and/or microbiological substances. The process, wherein the wells are made in the plate with the aid of a molding die, comprises the steps of:a) Applying a plastic film, which is deformable by the action of heat, on a molding block which serves as a molding die and which has the negative shape of the wells to be formed; andb) subjecting the plastic film, for a predetermined period of time, to the action of a hot gas flow of a predetermined first temperature, the gas flow impinging upon at least an area of the plastic film covering one of the recessed portions, heating up this area and pressing it into the recessed portion so that it comes to lie flat against the latter's inner wall which is smooth throughout.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: September 5, 1995
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Manfred Eigen, Wolfgang Simm
  • Patent number: 5430957
    Abstract: A device (10) for tempering substances has a metal block arrangement (12) th at least one zone (32) the temperature of which can be set at a determined mean value, as well as at least another zone (32'). The device (10) has a metallic base plate (31) with a receptacle for the substances, and at least one of its outer surfaces can be brought into thermal contact with the metal block arrangement (12). In addition, a pressure generator (49) generates a pressure that deviates from the ambient pressure between at least one outer surface and the metal block arrangement. The device (10) further has a conveyor (33) that selectively conveys the base plate (31) into one of the zones (32, 32') of the metal block arrangement (12) along a conveying path (44). The pressure generator (49) is capable of generating an overpressure or a depression.
    Type: Grant
    Filed: March 10, 1993
    Date of Patent: July 11, 1995
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Manfred Eigen, Wolfgang Simm, Roderich Weise
  • Patent number: 5207382
    Abstract: An autogenous flame spraying apparatus includes a supply line housing having gas supply lines for combustion gas, carrier gas and acceleration gas; a main housing connected to the supply line housing and having a supply line for a spray powder, and ducts communicating with the gas supply lines, the housing having a first injector for mixing the spray powder and the carrier gas to form a first mixture; an interchangeable nozzle carrier for carrying a releasable torch nozzle, the carrier being releasably attached to the main housing and having a second injector for mixing the combustion gas and the carrier gas to form a second mixture, the nozzle carrier also having ducts for conveying the first mixture and the second mixture to the torch nozzle, whereby the carrier can be replaced so as to alter both flame power and feed of spray powder.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: May 4, 1993
    Assignee: Eutectic Corporation
    Inventors: Wolfgang Simm, Hans-Theo Steine, Peter Sommer
  • Patent number: 5082179
    Abstract: A flame spray directing means for connection to a flame spray nozzle of an autogenous flame-spraying apparatus for optimizing the working parameters of the apparatus including flame speed and kinetic energy is provided. The means comprises a hollow longitudinally extending module of tubular configuration through which flame spray material is caused to flow. The extending module has a predetermined length with one end portion thereof shaped for coupling to the flame spray nozzle and for providing a combustion chamber therefor, with its opposite end portion providing an exit end therefor. A portion of the hollow module extending from the combustion chamber to the exit end coaxially defines an extending accelerating chamber which is divided into a first stage chamber of specified diameter following the combustion chamber and a second stage chamber in which the diameter thereof less than that of the combustion chamber.
    Type: Grant
    Filed: November 19, 1990
    Date of Patent: January 21, 1992
    Assignee: Castolin S.A.
    Inventors: Wolfgang Simm, Hans-Theo Steine
  • Patent number: 5047265
    Abstract: A method is provided for flame-spraying powdered materials onto a substrate by means of an autogenous flame-spraying apparatus of the type in which a combustion gas-oxidation gas mixture is produced and ignited at the outlet of a burner nozzle with the powdered material conveyed by a carrier gas to the burner nozzle and introduced in the flame at the outlet of the burner nozzle. The working parameters of the flame-spraying apparatus are chosen so as to provide an energy constant P.sub.E which together with the kinetic energy E.sub.k of the particles enables the use of a broad range of flame speeds.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: September 10, 1991
    Assignee: Castolin S.A.
    Inventors: Wolfgang Simm, Hans-Theo Steine
  • Patent number: 5014915
    Abstract: An apparatus for the flame spraying of powder materials by means of an autogenous flame comprising a nozzle carrier which has a burner nozzle and which projects into a guide opening of a preferably tubular attachment body provided with coolant guide means surrounding the burner nozzle, in particular an attachment body which is provided with an accelerating tube, is to be improved in that the nozzle carrier (10) is surrounded by a nozzle means (30) for construction of the flame and the nozzle means has an outlet opening or openings for constricting gas, the opening or openings extending axially or radially relative to the burner nozzle (11). The constricting gas is supplied through an annular stabilization chamber (28). In an embodiment the stabilization chamber (28) is of variable and is provided with an annular discharge gap (34) as the outlet opening.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: May 14, 1991
    Assignee: Castolin S.A.
    Inventors: Wolfgang Simm, Hans-Theo Steine, Karl P. Streb
  • Patent number: 5005764
    Abstract: An apparatus for flame spraying, in particular of powder material by means of an autogenous flame, comprising a nozzle carrier which has a burner nozzle and which can be connected to a preferably tubular accelerating accessory device which is provided with coolant guide means surrounding the burner nozzle, is improved in that the accelerating accessory device (40) bears slidably against a central arm (12) of the nozzle carrier (10) with an axial portion (45), a conical region (44) adjoins the axial portion (45) at a position remote from the nozzle, and a portion (42) which outwardly embraces a combustion chamber (50) adjoins the conical region (44), wherein the combustion chamber is delimited towards the burner by a movable annular body (38). In addition the burner nozzle (9) is to be disposed approximately in one plane with flame outlet openings of the accelerating accessory device (40) and is adapted to be retracted and extended.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: April 9, 1991
    Assignee: Castolin S.A.
    Inventors: Wolfgang Simm, Hans-Theo Steine, Karl P. Streb
  • Patent number: 4906431
    Abstract: The present invention relates to a heat insulating separation wall between the combustion chamber of a solid fuel rocket and a chamber containing an electronic control installation of said rocket.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: March 6, 1990
    Assignee: Castolin S.A.
    Inventors: Niels Brundbjerg, Wolfgang Simm
  • Patent number: 4906529
    Abstract: A method is provided for producing an erosion-resistant layer or coating on the surface of a metallic workpiece. The method includes providing a thermally sprayable alloy of Ni-Cr-Fe-B-Si and thermally spraying the alloy on the workpiece to a specified thickness, following which the sprayed-on layer is heated in vacuum to a temperature between 250.degree. C. to 400.degree. C. for a time at the stated temperature of about 5 to 30 minutes sufficient to effect degassing of the layer. The temperature of the layer is thereafter raised to a range of about 800.degree. C. to 950.degree. C. and maintained at that temperature in vacuum for between 5 to 30 minutes. The temperature at the layer is then raised to between 900.degree. C. and 1100.degree. C. under a protctive atmoshpere at a pressure of between 200 to 600 mm Hg to effect fursion of the layer at above its melting point, following which the coated metallic workpiece is finally cooled to room temperature under the protective atmosphere.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: March 6, 1990
    Assignee: Castolin S.A.
    Inventors: Niels Brundbjerg, Wolfgang Simm
  • Patent number: 4751367
    Abstract: The present arrangement comprises a welding current generator for the generation of a d.c. portion of the desired welding current, as well as a pulse current source, the output circuits of which are connected in parallel with one another to the output terminals of the arrangement. The pulse current source is of the type having a high-frequency transformer in association with control means connected at the primary side thereof and delivers current pulses from a series of high-frequency pulses with a high no-load peak voltage. This enables pulsed welding currents to be generated in an extremely economical way by the employment of existing d.c. welding generators together with small, relatively low-cost additional equipment.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: June 14, 1988
    Assignee: Castolin S.A.
    Inventor: Wolfgang Simm
  • Patent number: 4711627
    Abstract: A spray gun comprises a nozzle defining an elongated, axially extending spray channel, a coaxial inlet leading thereto and having a flow-accelerating contour, and a coaxial combustion chamber leading to the inlet, the combustion chamber having a diameter larger than that of the spray channel. A nozzle head is displaceably mounted in the combustion chamber and is axially adjustable with respect to the inlet, the nozzle head feeding the fusible material into the combustion chamber and carrying a burner nozzle and respective conduits feeding a combustion gas and a spray channel flushing gas into the combustion chamber.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: December 8, 1987
    Assignee: Castolin S.A.
    Inventors: Manfred Oeschsle, Uwe Szieslo, Karl-Peter Streb, Wolfgang Simm
  • Patent number: 4681734
    Abstract: A powdery material is prepared by atomization from a molten alloy having the following composition in weight percent: chromium: 10-30; aluminium: 1-25; carbon: less than 0.5; nickel: less than 10; iron: the balance, with a cooling speed at least equal to 400.degree. C./sec., for heat spraying having a grain size comprised between -150 and +27 microns of which the specific area is higher than 500 cm.sup.2 /g. Said material enables to form on a metal substrate a self-adhesive layer having a resistance to pulling by traction which is higher than 20 N/mm.sup.2.
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: July 21, 1987
    Assignee: Castolin S.A.
    Inventors: Wolfgang Simm, Hans-Theo Steine
  • Patent number: 4609401
    Abstract: A powdered material is provided for thermal spraying comprising a mixture of self-fluxing matrix allow powder and a powder of at least one metal carbide, the carbide content of the mixture consisting essentially between 20 and 80 percent by thereof and the matrix alloy having the following composition, in percent by weight:______________________________________ Cr 18.0-35.0% Fe 0.1-25.0% B 0.5-4.5% Si 0.5-5.5% C 0.01-2.0% Mo 0-15.0% Nb 0-2.0% Ni Remainder.
    Type: Grant
    Filed: October 18, 1984
    Date of Patent: September 2, 1986
    Assignee: Castolin S.A.
    Inventors: Wolfgang Simm, Hans-Theo Steine
  • Patent number: 4594103
    Abstract: The material according to the present invention comprises a self-flowing alloy containing particularly from 18 to 35% by weight of chromium as well as fractions of boron and silicon in a ratio of 3:4. The alloy also contains from 0.1 to 25.0% by weight of iron, except for the range from 1.5 to 6. The layers obtained by means of said material exhibit a very high resistance to temperatures, particularly also to corrosion and oxidation.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: June 10, 1986
    Assignee: Castolin S.A.
    Inventors: Wolfgang Simm, Hans-Theo Steine