Patents by Inventor Wolfgang Skranc

Wolfgang Skranc has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process-scale synthesis of urolithin A
    Patent number: 12338224
    Abstract: Methods for preparing a salt of urolithin A and, in turn, urolithin A. Combining in an alkaline aqueous solution a copper-containing catalyst, 2-bromo-5-hydroxybenzoic acid, and resorcinol produces a salt of urolithin A. Urolithin A has been prepared by protonating a salt of the compound.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: June 24, 2025
    Assignee: Amazentis SA
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Process for the production of substituted 2-[2-(phenyl) ethylaminojalkaneamide derivatives
    Patent number: 12134589
    Abstract: The present invention relates to a new process for the production of substituted 2-[2-(phenyl) ethylaminojalkaneamide derivatives of the following formula (I), in particular 2-[2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylacetamide in high yields with very high chemical purity.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: November 5, 2024
    Assignee: Newron Pharmaceuticals S.p.A.
    Inventors: Wolfgang Skranc, Michael Wolberg, Matthias Riepl, Christoph Imboden, Erwin Waldvogel
  • PROCESS-SCALE SYNTHESIS OF UROLITHIN A
    Publication number: 20230357176
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 24, 2023
    Publication date: November 9, 2023
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Process-scale synthesis of urolithin A
    Patent number: 11634401
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: April 25, 2023
    Assignee: Amazentis SA
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • PROCESS FOR THE PRODUCTION OF SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO]ALKANEAMIDE DERIVATIVES
    Publication number: 20220177417
    Abstract: The present invention relates to a new process for the production of substituted 2-[2-(phenyl) ethylaminojalkaneamide derivatives of the following formula (I), in particular 2-[2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylacetamide in high yields with very high chemical purity.
    Type: Application
    Filed: April 8, 2020
    Publication date: June 9, 2022
    Applicant: Newron Pharmaceuticals S.p.A.
    Inventors: Wolfgang Skranc, Michael Wolberg, Matthias Riepl, Christoph Imboden, Erwin Waldvogel
  • PROCESS-SCALE SYNTHESIS OF UROLITHIN A
    Publication number: 20210198225
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 5, 2021
    Publication date: July 1, 2021
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Process-scale synthesis of urolithin A
    Patent number: 10906883
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: February 2, 2021
    Assignee: Amazentis SA
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • PROCESS-SCALE SYNTHESIS OF UROLITHIN A
    Publication number: 20190263772
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 27, 2019
    Publication date: August 29, 2019
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Process-scale synthesis of urolithins
    Patent number: 9573922
    Abstract: Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially advantageous for the large-scale preparation of urolithins or intermediates or analogs thereof. The method may optionally include the preparation of a urolithin, or an intermediate or analog thereof, as a pharmaceutically acceptable salt.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: February 21, 2017
    Assignee: Amazentis SA
    Inventors: Christopher Rinsch, Roland Mueller, Wolfgang Skranc
  • PROCESS-SCALE SYNTHESIS OF UROLITHINS
    Publication number: 20160326131
    Abstract: Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially advantageous for the large-scale preparation of urolithins or intermediates or analogs thereof. The method may optionally include the preparation of a urolithin, or an intermediate or analog thereof, as a pharmaceutically acceptable salt.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 10, 2016
    Inventors: Christopher Rinsch, Roland Mueller, Wolfgang Skranc
  • Process-scale synthesis of urolithins
    Patent number: 9394269
    Abstract: Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially advantageous for the large-scale preparation of urolithins or intermediates or analogs thereof. The method may optionally include the preparation of a urolithin, or an intermediate or analog thereof, as a pharmaceutically acceptable salt.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: July 19, 2016
    Assignee: Amazentis SA
    Inventors: Christopher L. Rinsch, Roland Müller, Wolfgang Skranc
  • Process-Scale Synthesis of Urolithins
    Publication number: 20150183758
    Abstract: Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially advantageous for the large-scale preparation of urolithins or intermediates or analogs thereof. The method may optionally include the preparation of a urolithin, or an intermediate or analog thereof, as a pharmaceutically acceptable salt.
    Type: Application
    Filed: December 22, 2014
    Publication date: July 2, 2015
    Inventors: Christopher L. Rinsch, Roland Müller, Wolfgang Skranc
  • Polypeptide having esterase activity and recombinant esterase and use thereof
    Patent number: 8642312
    Abstract: Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: February 4, 2014
    Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KG
    Inventors: Gerhard Steinbauer, Micheal Stanek, Peter Pojarliev, Wolfgang Skranc, Helmut Schwab, Joannes Kierkels, Marcel Wubbolts, Harald Pichler, Manuela Hermann, Christoph Zenzmaier
  • Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative
    Patent number: 8314238
    Abstract: The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-?-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: November 20, 2012
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Erhard Bappert, Andreas Hendrikus Maria De Vries, Doris Domin, Matthias Helms, Christoph Imboden, Zarghun Nazir, Wolfgang Skranc, Felix Spindler, Michael Stanek, Wilhelm Tschebull, Gerardus Karel Maria Verzijl
  • NOVEL POLYPEPTIDE HAVING ESTERASE ACTIVITY AND RECOMBINANT ESTERASE AND USE THEREOF
    Publication number: 20120220014
    Abstract: Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
    Type: Application
    Filed: March 12, 2012
    Publication date: August 30, 2012
    Applicant: DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG
    Inventors: Gerhard Steinbauer, Michael Stanek, Peter Pojarliev, Wolfgang Skranc, Helmut Schwab, Joannes Kierkels, Marcel Wubbolts, Harald Pichler, Manuela Hermann, Christoph Zenzmaier
  • Trisubstituted 3,4-dihydro-1H-isoquinolin compound, process for its preparation, and its use
    Patent number: 8247560
    Abstract: The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: August 21, 2012
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Maria Andreas Hendrikus De Vries, Doris Domin, Matthias Helms, Christoph Imboden, Ralph Koberstein, Zarghun Nazir, Wolfgang Skranc, Michael Stanek, Wilhelm Tschebull, Maria Gerardus Karel Verzijl, Jurgen Stichler
  • Polypeptide having esterase activity and recombinant esterase and use thereof
    Patent number: 8158393
    Abstract: Method of resolving stereoselectively racemic 2-alkyl-5-halopent-4-ene-carboxylic esters of the formula (I) in which R is a C1-C6-alkyl radical, R1 is C1-C4-alkyl and X is chlorine, bromine or iodine, by contacting a racemic ester of formula (I) with a polypeptide or recombinant protein having esterase activity and exhibiting an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ. ID. No. 1.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: April 17, 2012
    Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KG
    Inventors: Gerhard Steinbauer, Micheal Stanek, Peter Pojarliev, Wolfgang Skranc, Helmut Schwab, Marcel Wubbolts, Joannes Kierkels, Harald Pichler, Manuela Hermann, Christoph Zenzmaier
  • PROCESS FOR THE PREPARATION OF AN ENANTIOMERIC TRISUBSTITUTED 3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE
    Publication number: 20100305325
    Abstract: The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-?-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.
    Type: Application
    Filed: December 23, 2008
    Publication date: December 2, 2010
    Inventors: Erhard Bappert, Andreas Hendrikus Maria De Vries, Doris Domin, Matthias Helms, Christoph Imboden, Zarghun Nazir, Wolfgang Skranc, Felix Spindler, Michael Stanek, Wilhelm Tschebull, Gerardus Karel Maria Verzijl
  • NOVEL POLYPEPTIDE HAVING ESTERASE ACTIVITY AND RECOMBINANT ESTERASE AND USE THEREOF
    Publication number: 20100151541
    Abstract: Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 17, 2010
    Inventors: Gerhard Steinbauer, Micheal Stanek, Peter Pojarliev, Wolfgang Skranc, Helmut Schwab, Marcel Wubbolts, Joannes Kierkels, Harald Pichler, Manuela Hermann, Christoph Zenzmaier
  • WHOLE-CELL CATALYTIC SYSTEM COMPRISING A HYDANTOINASE, A RACEMASE AND A CARBAMOYLASE
    Publication number: 20100143981
    Abstract: The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched ?-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The present invention further relates to the use of such a whole cell catalytic system according in the preparation of an enantiomerically enriched L-?-amino acid from a corresponding hydantoin.
    Type: Application
    Filed: December 4, 2007
    Publication date: June 10, 2010
    Inventors: Monika Rusnak-Müller, Oliver May, Petrus Johannes Hermsen, Henricus Martinus Maria Gerardus Straatman, Wolfgang Skranc, Wilhelmus Hubertus Joseph Boesten, Dannis Heemskerk, Ben De Lange, Georgios Sarakinos