Abstract: The present invention discloses compounds of the general formula: ##STR1## The compounds are highly isozyme selective protein kinase C beta-1 and beta-2 isozyme inhibitors. Accordingly, the present invention provides a method of selectively inhibiting protein kinase C isozymes beta-1, and beta-2. As isozyme selective inhibitors of beta-1 and beta-2, the compounds are therapeutically useful in treating conditions associated with diabetes mellitus and its complications, as well as other disease states associated with an elevation of the beta-1 and beta-2 isozyme.

Abstract: Compounds for the treatment of cardiac insufficiency, an arterial thrombo embolism, an arterial occlusive disease, psoriasis, neurodermatitis, asthma, platelet aggregation and hypertension, of the formula ##STR1## in which R.sub.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl or C.sub.3-7 -cycloalkyl,R.sub.2 is hydrogen, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl or C.sub.1-6 -hydroxyalkyl,R.sub.1 and R.sub.2 together with the carbon atom which carries them can be C.sub.3-7 -spiroalkyl,R.sub.3 is hydrogen or C.sub.1-6 -alkyl, andR.sub.4 is a cyanamido group, a 4-difluoromethoxy-3-pyridyl group or a C.sub.1-2 -nitroalkyl group, andZ is oxygen or sulphur,or a salt, acid addition salt, tautomer or optical isomer thereof.

Abstract: Indolylpropanols of the formula I ##STR1## in which R.sup.1 and R.sup.2, which can be identical or different, in each case denote a 2-, 3- or 4-pyridinyl or a 2- or 3-thienyl radical, phenyl or phenyl which is optionally monosubstituted or identically or differently disubstituted by halogen, alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxy, where alkyl denotes straight-chain alkyl having 1 to 6 carbon atoms or branched alkyl having 3 to 6 carbon atoms, and their salts and acid addition salts, tautomers and optical isomers show positive inotropic and antiarrhythmic activity.

Abstract: Benzopyran derivatives of the general formula I ##STR1## wherein the substituents are as defined herein are provided. The compounds show vasodilating and vascular spasmolytic activity and are useful in treating hypertension.

Abstract: Benzopyran derivatives of the general formula I ##STR1## are disclosed. The compounds are therapeutic active compounds.

Abstract: Pharmaceutical composition containing moxonidine (4-chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine) or its pharmaceutically acceptable salts and hydrochlorothiazide (6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide ) and, if appropriate, triamterene (2,4,7-triamino-6-phenylpteridine).

Abstract: Substituted indolylpropanols of the formula I ##STR1## in which R.sup.1 denotes a cyano, carboxamido, alkoxycarbonyl, hydroxyl or acetyl group,Y stands for the group A ##STR2## wherein n is the number 2 or 3, or the group B, ##STR3## R.sup.2 stands for R.sup.2 ' where Y denotes the group A and for R.sup.2 " when Y denotes the group B, whereR.sup.2 ' denotes pyridinyl, thienyl or substituted phenyl which is monosubstituted or disubstituted by difluoromethoxy, difluoromethylthio, trifluoromethoxy, trifluoromethylthio, trifluoroethoxy, alkoxyalkoxy, cycloalkylalkoxy, alkoxyalkyl, alkylthioalkoxy, alkylsulphinylalkoxy, alkylsulphonylalkoxy, alkoxyalkylthio, alkoxyalkylsulphinyl, alkoxyalkylsulphonyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl and dialkylaminoalkoxy, andR.sup.

Abstract: Pyrido[1,8]naphthyridinones of the general formula I ##STR1## in which R.sup.1 denotes hydrogen, a straight-chain or branched alkyl group having 1 to 6 carbon atoms, the phenyl group or a substituted phenyl group, a cycloalkyl group, a carboxyl group, an alkoxycarbonyl group, a carboxamide group or a cyano group,R.sup.2 denotes hydrogen or a straight-chain or branched alkyl group having 1 to 4 carbon atoms,R.sup.3 denotes hydrogen, a straight-chain or branched alkyl group having 1 to 4 carbon atoms, a carboxyl group, an alkoxycarbonyl group, a carboxamide group or a cyano group,R.sup.

Abstract: Substituted phenylpiperazinyl-propanols of the formula I ##STR1## in which R.sup.1 denotes hydrogen or an alkyl group with 1 to 4 carbon atoms and R.sup.2 and R.sup.3, which can be identical or different, each denote hydrogen, halogen, cyano, a trifluoromethyl group, a nitro group, a hydroxyl group, an alkoxy group or an alkyl group with in each case 1 to 4 carbon atoms, it being possible for the alkyl parts in each case to be straight-chain or branched, and their tautomeric forms and their salts as well as acid addition salts and N-oxides, have useful pharmacological properties, in particular a positively inotropic, vasodilating, broncholytic and platelet aggregation-inhibiting action and are therefore suitable for the treatment of cardiac insufficiency, hypertension, asthma and thrombosis.

Abstract: New substituted phenyl-2-(1H)-pyrimidinones of the general formula I ##STR1## in which R.sup.1 denotes an alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3, which can be identical or different, each denote hydrogen, halogen, cyano, a trifluoromethyl group, a hydroxyl group or an alkoxy group having 1 to 4 carbon atoms, it being possible for each alkyl moiety to be straight-chain or branched, and their tautomeric forms and their acid addition salts and N-oxides have a positive inotropic effect and can thus be used as medicaments for the treatment of cardiac insufficiency.

Abstract: Pyrimidyl thioureas of the formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 individually represent hydrogen, halogen, a linear or branched alkoxy group, or a linear or branched alkyl group, said groups having 1 to 8 carbon atoms, and their pharmaceutically acceptable salts. These compounds are useful for the treatment of hyperlipidemia and hypertension.Compositions containing these compounds as well as methods of use and preparation thereof are also disclosed.

Abstract: Substituted aryloxyamino propanols and pharmaceutically acceptable acid addition salts thereof according to the following formula ##STR1## wherein X is selected from oxygen and NH, R.sup.1 is selected from hydrogen, amino and acylamino having 1 to 8 carbon atoms, R.sup.2 is selected from isopropyl, tertiarybutyl, and 2-(3,4-dimethoxyphenethyl), are disclosed which are useful as anti-hypertensive and .beta.-adrenolytic agents. Also, substituted aryl azoles selected from 3-aryl pyrazoles and 5-aryl oxazoles having the formula ##STR2## wherein X and R.sup.1 are the same, and R.sup.3 is selected from hydrogen, the radical ##STR3## are disclosed which are useful in the preparation of the substituted aryloxyamino propanols of Formula I. Compositions containing the aryloxyamino propanols, and methods of preparation are also disclosed.

Abstract: The present invention is directed to certain aminopyrimidines of the general formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are hydrogen, halogen, alkoxy, alkylthio, or alkyl having 1 to 4 carbon atoms, or cycloalkyl having 3 to 5 carbon atoms and R.sup.4 is hydrogen or an aliphatic or aromatic acyl group, as well as physiologically compatible acid addition salts thereof. Compounds of the present invention are useful as blood pressure lowering agents and in the treatment of glaucoma.