Abstract: A granules syringe, particularly for impregnating granules of a bone cement with blood and for dispensing the impregnated granules, includes a transparent tubular barrel for receiving the granules between a porous front cover and a porous plug. A piston which is separate from the plug and has an integrated seal is disposed behind the plug. When the piston is retracted, the seal is closed so that the vacuum is generated to suck the blood through the porous cover into the granules. When the piston is subsequently advanced, the seal opens so that air has been removed from the granules and passed through the porous plug is permitted to escape rewardly. Upon removal of the cover, the plug is then advanced by the piston to dispense the impregnated granules.