Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: A thermal and acoustic insulation system for an aircraft, to be received between an inner surface of an aircraft primary structure, such as an aircraft fuselage structure, and a surface of a panel arrangement delimiting an aircraft cabin, the surface facing away from the aircraft cabin, comprises an insulation package and at least one sensor adapted to measure a level of humidity present in the insulation package. The insulation package comprises a core layer having a thermal and acoustic damping performance, and a packing layer enclosing the core layer. The packing layer is provided with a plurality of normally closed and selectively openable drainage openings which are actuatable to change between their normally closed state and an open state.

Abstract: A multifunctional thermal and acoustic insulation system having a multilayer structure and a plurality of functional components formed integrally and non-exchangeably with the multilayer structure. The multilayer structure has a thermal and acoustic damping performance and comprises, in a stacked arrangement, a continuous first outer layer, a core layer and a continuous second outer layer. The core layer is between the outer layers so that the outer layers cover the core layer at least on opposite sides thereof. Functions of the functional components are related to at least one of the thermal and the acoustic damping performance of the multilayer structure and the functional components are provided on a first outer layer side of the core layer and/or on a second outer layer side of the core layer.

Abstract: A disposable absorbent article may include a chassis that includes a topsheet, a backsheet, and an absorbent core disposed between the topsheet and the backsheet; and a leg gasketing system and a waist gasketing element. The leg gasketing system may include an inner cuff and an outer cuff; the inner cuff may include an inner cuff folded edge and an inner cuff material edge and the outer cuff may include an outer cuff material edge such that the web of material is folded outward to form the inner cuff folded edge. When tested by the Blowout Method Test as described herein, the disposable absorbent article has a Blowout Percent Leakage of less than about 9.0%.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: An exemplary method and apparatus are provided for transmitting an asynchronous transport signal over an optical fiber section of an Optical Transport Network. Higher order Optical Data Units of an asynchronous transport signal to be transmitted may be encapsulated into outer transport frames that offer a payload rate higher than a nominal bit rate of the asynchronous transport signal. An output optical signal, which contains the outer transport frames with the encapsulated asynchronous transport signal, is generated at a locally generated clock rate and transmitted over an optical fiber section. To encapsulate the asynchronous transport signal, its bit rate is adapted to the payload rate of the outer transport frames, which is derived from the locally generated clock through a justification and stuffing process. The rate adapted transport signal is then synchronously mapped into the outer transport frames at the rate of the locally generated clock.

Abstract: An exemplary method and apparatus are provided for transmitting an asynchronous transport signal over an optical fiber section of an Optical Transport Network. Higher order Optical Data Units of an asynchronous transport signal to be transmitted may be encapsulated into outer transport frames that offer a payload rate higher than a nominal bit rate of the asynchronous transport signal. An output optical signal, which contains the outer transport frames with the encapsulated asynchronous transport signal, is generated at a locally generated clock rate and transmitted over an optical fiber section. To encapsulate the asynchronous transport signal, its bit rate is adapted to the payload rate of the outer transport frames, which is derived from the locally generated clock through a justification and stuffing process. The rate adapted transport signal is then synchronously mapped into the outer transport frames at the rate of the locally generated clock.

Abstract: The present invention includes method and apparatus for storing provisioned information within the optical switches and retrievable by every controller. The optical switches perform failure isolation according to their provisioning information. The optical switches monitor each channel for loss of signal. The provisioning information is shared autonomously between the optical switches allowing the switches to retrieve the provisioning information of the network topology from any other optical switch in the network. Fault isolation is done by the optical switch on the level of optical switch provisioning following the paradigm of “single alarm for single fault,” thus avoiding alarm floods and ambiguous alarms, thereby saving the operator time and money.

Abstract: The invention includes a method and apparatus for controlling information available at a network element located at a first hierarchical level in a content distribution network. A method includes determining a subset of content using content forecast information, comparing the determined subset of content to a subset of content available to the network element located at the first hierarchical level, generating a request adapted for modifying the available subset of content in response to a difference between the determined and available subsets of content, and propagating the request toward a network element at a second hierarchical level in the content distribution network, where the first and second hierarchical levels are different. The content may include any information adapted for being distributed from a server to a subscriber terminal (e.g.

Abstract: The invention includes a method and apparatus for determining the performance of a virtual concatenation group (VCG) signal transporting a client signal over a transport network. A method includes collecting a plurality of performance monitoring indicators associated with a plurality of VCG member signals of the VCG signal, synchronizing the performance monitoring indicators with respect to each other, combining the synchronized performance monitoring indicators to form VCG-level performance monitoring indicators, calculating VCG-level performance monitoring primitive measurements based on the VCG-level performance monitoring indicators, and processing the VCG-level performance monitoring primitive measurements to determine VCG performance.

Abstract: The invention comprises a method and apparatus for computing virtual concatenation group bandwidth data of at least one virtual concatenation group. Specifically, the method comprises determining at least one elementary path of which at least one virtual concatenation group is composed, determining elementary path data associated with the at least one elementary path and computing virtual concatenation group bandwidth data using the elementary path data.

Abstract: The invention includes a method and apparatus for determining the performance of a virtual concatenation group (VCG) signal transporting a client signal over a transport network. A method includes collecting a plurality of performance monitoring indicators associated with a plurality of VCG member signals of the VCG signal, synchronizing the performance monitoring indicators with respect to each other, combining the synchronized performance monitoring indicators to form VCG-level performance monitoring indicators, calculating VCG-level performance monitoring primitive measurements based on the VCG-level performance monitoring indicators, and processing the VCG-level performance monitoring primitive measurements to determine VCG performance.

Abstract: The invention includes a method and apparatus for controlling information available at a network element located at a first hierarchical level in a content distribution network. A method includes determining a subset of content using content forecast information, comparing the determined subset of content to a subset of content available to the network element located at the first hierarchical level, generating a request adapted for modifying the available subset of content in response to a difference between the determined and available subsets of content, and propagating the request toward a network element at a second hierarchical level in the content distribution network, where the first and second hierarchical levels are different. The content may include any information adapted for being distributed from a server to a subscriber terminal (e.g.

Abstract: The present invention includes method and apparatus for storing provisioned information within the optical switches and retrievable by every controller. The optical switches perform failure isolation according to their provisioning information. The optical switches monitor each channel for loss of signal. The provisioning information is shared autonomously between the optical switches allowing the switches to retrieve the provisioning information of the network topology from any other optical switch in the network. Fault isolation is done by the optical switch on the level of optical switch provisioning following the paradigm of “single alarm for single fault,” thus avoiding alarm floods and ambiguous alarms, thereby saving the operator time and money.

Abstract: The invention comprises a method and apparatus for computing virtual concatenation group bandwidth data of at least one virtual concatenation group. Specifically, the method comprises determining at least one elementary path of which at least one virtual concatenation group is composed, determining elementary path data associated with the at least one elementary path and computing virtual concatenation group bandwidth data using the elementary path data.

Abstract: In an electrical drive mechanism, in particular for motor vehicles, having a commutator motor (14) disposed in a housing (10), which commutator motor (14) has a rotor shaft (17) with a commutator (22) non-rotatably supported on it and has a brush holder (30) affixed to the housing (10), and having a bearing (25) disposed in the vicinity of the commutator (22), which bearing has a bearing bush (34) that encloses the rotor shaft (17) with rotary play and a bearing seat (35) that contains the bearing bush (34), in order to achieve a simple embodiment for the bearing (25), a clamping member (37) is formed onto the brush holder (30) of one piece with it, which clamps the bearing bush (34) in a frictionally engaged, axial fashion in the bearing seat (35) formed in the housing (10) (FIG. 1).

Abstract: The invention relates to a method for a pattern representation of inhomogeneous crossing grids of warp and weft yarns, in which a) an inhomogeneous real crossing grid is predetermined based on the real warp yarn density and the real weft yarn density, b) a homogenous virtual point grid with considerably increased resolution is overlaid onto the inhomogeneous real crossing grid, c) a pattern is represented in the homogenous virtual point grid, and d) those points of the virtual homogenous point grid are determined which coincide with crossing points of the real inhomogeneous crossing grid of the pattern.

Abstract: A method for representing optically a fabric consisting of warp and weft threads and with a pattern. To optically represent the fabric, the pattern is acquired by scanning from a model, or from an existing data carrier, or represented directly on a computer display. A crossing scheme is then assigned to the warp and weft threads. The course of the warp and weft threads is then determined by varying at least one of any parameters specific for the thread, such as the number of color components of a single thread and their distribution, the construction of the thread's surface or the material of the thread and by varying at least one of any parameter specific for the fabric, such as the closeness of the warp and weft threads, the advance of material in weaving, the sequence of the warp threads or the control functions for a weaving machine.

Abstract: A process for determining the arrangement and step sequence of heald shafts of a heald loom for weaving a fabric including a backing fabric having a fabric pattern and an ornamental design. The ornamental design of the fabric is plotted and/or displayed by means of a computer. Alternatively, the combined appearance of the ornamental design and the fabric pattern may be plotted and/or displayed. Next, the number of heald shafts necessary for weaving the ornamental design or the combined appearance is determined. Heald shaft arrangements that are conventionally used and/or available which will weave a fabric design similar to the ornamental design or the combination designed are plotted and compared with the heald shafts determined for weaving the ornamental design or the combination design. The step sequence of the individual heald shafts in the heald loom from the assigned heald shaft arrangement is determined.