Patents by Inventor Wolfgang von der Saal

Wolfgang von der Saal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110218199
    Abstract: Compounds of formula I are disclosed. These compounds are useful in the control or prevention of cancer.
    Type: Application
    Filed: August 20, 2008
    Publication date: September 8, 2011
    Inventors: Guy Georges, Klaus Kaluza, Matthias Koerner, Ulrike Reiff, Stefan Scheiblich, Wolfgang Von Der Saal, Stefan Weigand
  • Patent number: 7939532
    Abstract: Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: May 10, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Frederick Brookfield, Jonathan Gridley, Lothar Kling, Michael Prime, Ulrike Reiff, Wolfgang Von Der Saal, Thomas Von Hirschheydt
  • Patent number: 7879884
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: February 1, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Frederick Brookfield, Lothar Kling, Ulrike Reiff, Wolfgang Von der Saal, Thomas Von Hirschheydt
  • Publication number: 20100292247
    Abstract: Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: October 24, 2007
    Publication date: November 18, 2010
    Applicant: F. HOFFMANN-LA ROCHE AG
    Inventors: Frederick Brookfield, Jonathan Gridley, Lothar Kling, Michael Prime, Ulrike Reiff, Wolfgang von der Saal, Thomas von Hirschheydt
  • Publication number: 20100256200
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: May 14, 2008
    Publication date: October 7, 2010
    Inventors: Frederick Brookfield, Lothar Kling, Ulrike Reiff, Wolfgang Von der Saal, Thomas Von Hirschheydt
  • Patent number: 7625896
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: December 1, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Lothar Kling, Ulrike Reiff, Manfred Schwaiger, Georg Tiefenthaler, Wolfgang von der Saal, Thomas von Hirschheydt
  • Patent number: 7226923
    Abstract: Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: June 5, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Edward Boyd, Frederick Brookfield, Guy Georges, Bernhard Goller, Sabine Huensch, Petra Rueger, Matthias Rueth, Stefan Scheiblich, Christine Schuell, Wolfgang von der Saal, Justin Warne, Stefan Weigand
  • Publication number: 20070123513
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: November 8, 2006
    Publication date: May 31, 2007
    Inventors: Lothar Kling, Ulrike Reiff, Manfred Schwaiger, Georg Tiefenthaler, Wolfgang von der Saal, Thomas von Hirschheydt
  • Patent number: 7208506
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: April 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Thomas von Hirschheydt, Timothy Woodcock
  • Patent number: 7208526
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: April 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Matthias Koerner, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Timothy Woodcock
  • Publication number: 20070010564
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 11, 2007
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Thomas von Hirschheydt, Timothy Woodcock
  • Publication number: 20060270874
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 30, 2006
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Matthias Koerner, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Timothy Woodcock
  • Patent number: 7091229
    Abstract: A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: August 15, 2006
    Assignee: Hoffman-La Roche Inc.
    Inventors: Guy Georges, Adelbert Grossmann, Olaf Mundigl, Wolfgang von der Saal, Tim Sattelkau
  • Publication number: 20060089359
    Abstract: Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
    Type: Application
    Filed: September 23, 2005
    Publication date: April 27, 2006
    Inventors: Edward Boyd, Frederick Brookfield, Guy Georges, Bernhard Goller, Sabine Huensch, Petra Rueger, Matthias Rueth, Stefan Scheiblich, Christine Schuell, Wolfgang von der Saal, Justin Warne, Stefan Weigand
  • Patent number: 6800638
    Abstract: A compound of the formula (I) wherein A, R1, R2 and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: October 5, 2004
    Assignee: Hoffman-La Roche Inc.
    Inventors: Guy Georges, Adelbert Grossman, Olaf Mundigl, Wolfgang von der Saal, Tim Sattelkau
  • Publication number: 20040077698
    Abstract: A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5-7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.
    Type: Application
    Filed: July 24, 2003
    Publication date: April 22, 2004
    Inventors: Guy Georges, Adelbert Grossmann, Olaf Mundigl, Wolfgang von der Saal, Tim Sattelkau
  • Publication number: 20040053960
    Abstract: A compound of the formula (I) wherein A, R1, R2 and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.
    Type: Application
    Filed: June 23, 2003
    Publication date: March 18, 2004
    Inventors: Guy Georges, Adelbert Grossman, Olaf Mundigl, Wolfgang von der Saal, Tim Sattelkau
  • Patent number: 6512123
    Abstract: Compounds of formula I wherein R1, R2, A, X, Y and Z have the meanings provided in the specification, and their enantiomers, diastereoisomers, racemates, pharmaceutically acceptable salts and mixtures thereof. These compounds have HDAC inhibitory activity for inhibiting cell proliferation. Also provided is a process of manufacturing these compounds.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: January 28, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Adelbert Grossmann, Wolfgang von der Saal, Tim Sattelkau, Ulrich Tibes
  • Publication number: 20020183513
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: April 22, 2002
    Publication date: December 5, 2002
    Inventors: Adelbert Grossmann, Wolfgang von der Saal, Tim Sattelkau, Ulrich Tibes
  • Patent number: 6037334
    Abstract: Compounds of formula I ##STR1## in which R.sub.1, R.sup.2 are the same or different and denote a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, an alkenyl group, an alkinyl group or an aralkyl group or R.sup.1 and R.sup.2 together denote an alkylene residue which, together with the bound oxygen atoms and the phosphorus atom carrying the oxygen atoms, forms a saturated 5-membered to 8-membered ring;R.sup.3 denotes an optionally substituted amino group, an alkyl group, a cycloalkyl residue or an optionally substituted aryl residue;n denotes an integer between 1 and 4,as well as hydrates, solvates and physiologically tolerated salts thereof, their optically active forms, processes for their production as well as pharmaceutical preparations having factor Xa-inhibitory properties which contain these compounds.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: March 14, 2000
    Assignee: Roche Diagnostics GmbH
    Inventors: Ralf Kucznierz, Herbert Leinert, Wolfgang von der Saal, Richard Neidlein, Christiane Kehr