Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Tn antigen or sTn antigen. The compositions disclosed herein include isolated antibody or functional fragments thereof that binds to Tn antigen or sTn antigen and polynucleotides encoding the heavy chain and/or a light chain variable domains of such antibody or functional fragment. The invention also provides methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a localizing agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.

Abstract: A worm shaft for a mixing and kneading machine in particular for continuous preparation processes, comprising a shaft rod, on the circumferential surface of which blade elements are arranged which are spaced apart from one another and which extend outward from the circumferential surface of the shaft rod, wherein the blade elements are arranged on the shaft rod, at least in one section extending in the axial direction of the worm shaft, in three rows extending in the axial direction of the worm shaft, wherein at least one of the blade elements of one of the rows is different from one of the blade elements of one of the other rows, and/or the rows of blade elements, viewed in cross-section of the shaft rod, are distributed irregularly over the circumference defined by the outer circumferential surface of the shaft rod, and wherein the angular distance between the midpoints M of the outer circumferential surfaces of the blade elements on the circumferential surface of the shaft rod of adjacent rows differs betw

Abstract: A worm shaft for a mixing and kneading machine in particular for continuous preparation processes, comprising a shaft rod, on the circumferential surface of which blade elements are arranged which are spaced apart from one another and which extend outward from the circumferential surface of the shaft rod, wherein the blade elements are arranged on the shaft rod, at least in one section extending in the axial direction of the worm shaft, in three rows extending in the axial direction of the worm shaft, wherein at least one of the blade elements of one of the rows is different from one of the blade elements of one of the other rows, and/or the rows of blade elements, viewed in cross-section of the shaft rod, are distributed irregularly over the circumference defined by the outer circumferential surface of the shaft rod, and wherein the angular distance between the midpoints M of the outer circumferential surfaces of the blade elements on the circumferential surface of the shaft rod of adjacent rows differs betw

Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Tn antigen or sTn antigen. The compositions disclosed herein include isolated antibody or functional fragments thereof that binds to Tn antigen or sTn antigen and polynucleotides encoding the heavy chain and/or a light chain variable domains of such antibody or functional fragment. The invention also provides methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a localizing agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.

Abstract: A worm shaft for a mixing and kneading machine particularly for continual processing having a shaft bar, on the circumferential surface of which blade elements are arranged to be spaced apart from one another extending outwards from the circumferential surface of the shaft bar, wherein the blade elements are arranged on the circumferential surface of the shaft bar, at least in one section extending in the axial direction of the worm shaft, in two rows extending in the axial direction of the worm shaft, and wherein each of the blade elements of the at least one section extending in the axial direction of the worm shaft has an elliptic, oval, or biconvex outer peripheral surface in the top view.

Abstract: A worm shaft for a mixing and kneading machine particularly for continual processing having a shaft bar, on the circumferential surface of which blade elements are arranged to be spaced apart from one another extending outwards from the circumferential surface of the shaft bar, wherein the blade elements are arranged on the circumferential surface of the shaft bar, at least in one section extending in the axial direction of the worm shaft, in two rows extending in the axial direction of the worm shaft, and wherein each of the blade elements of the at least one section extending in the axial direction of the worm shaft has an elliptic, oval, or biconvex outer peripheral surface in the top view.

Abstract: With a mixing and kneading machine (100), wherein a worm shaft (12) moves in a housing (10) in a rotating manner and moves back and forth in a translatory movement, receptacles for kneading elements (12) are distributed non-uniformly. It is thereby possible to equip the receptacles with varying numbers of kneading elements. Quick adaptation is also thereby possible. In one embodiment, the number of kneading elements even varies over the extension direction of the mixing and kneading machine (100).

Abstract: Mixing and plasticating machine (100) for continuous conditioning processes, comprising: a housing (10) in which a hollow interior (18) is formed that is delimited by the interior peripheral surface of the housing (10) and extends in the longitudinal direction of the mixing and plasticating machine (100); a screw shaft (12) which extends through the interior (18) of the housing (10), rotates in the interior (18) of the housing (10) during operation and simultaneously moves translationally back and forth; a drive which rotates the screw shaft (12) during operation; and a filling device (36) arranged on the housing (10), for feeding at least one starting material into the interior (18) of the housing (10), the filling device (36) extending through a cut-out (42) that extends through the housing wall (40) or being connected to a cut-out (42) that extends through the housing wall (40), the filling device (36) comprising at least two cavities (54, 54?) that each extend over the height of the filling device (36), w

Abstract: The invention relates to a mixing and kneading machine for continuous preparation processes, such as for producing granules, extruded profiles, or molded articles, such as polymer granules, polymer extruded profiles, or polymer molded parts, having a feeding and mixing device (12) and a discharge device (14), wherein the feeding and mixing device includes a housing (18), a screw shaft (34), and a connecting element (24), wherein the connecting element is arranged at a front side of the housing and is also connected to the discharge device, wherein a hollow interior is formed in both the housing and the connecting element, and the screw shaft extends, at least sectionally, in the axial direction through the interior of the housing and, at least sectionally, in the axial direction through the interior of the connecting element, and wherein a plurality of kneading elements (40), which extend from the inner circumferential surface of the housing into the interior, are provided in the housing, and wherein kneading

Abstract: The present invention relates to a worm shaft for a mixing and kneading machine particularly for continual processing having a shaft bar, on the circumferential surface of which blade elements are arranged to be spaced apart from one another extending outwards from the circumferential surface of the shaft bar, wherein the blade elements are arranged on the circumferential surface of the shaft bar, at least in one section extending in the axial direction of the worm shaft, in two rows extending in the axial direction of the worm shaft.

Abstract: The present invention relates to a worm shaft for a mixing and kneading machine in particular for continuous preparation processes, comprising a shaft rod, on the circumferential surface of which blade elements are arranged which are spaced apart from one another and which extend outward from the circumferential surface of the shaft rod, wherein the blade elements are arranged on the shaft rod, at least in one section extending in the axial direction of the worm shaft, in three rows extending in the axial direction of the worm shaft, wherein at least one of the blade elements of one of the rows is different from one of the blade elements of one of the other rows, and/or the rows of blade elements, viewed in cross-section of the shaft rod, are distributed irregularly over the circumference defined by the outer circumferential surface of the shaft rod.

Abstract: With a mixing and kneading machine (100), wherein a worm shaft (12) moves in a housing (10) in a rotating manner and moves back and forth in a translatory movement, receptacles for kneading elements (12) are distributed non-uniformly. It is thereby possible to equip the receptacles with varying numbers of kneading elements. Quick adaptation is also thereby possible. In one embodiment, the number of kneading elements even varies over the extension direction of the mixing and kneading machine (100).

Abstract: A humeral cut guide system for a humeral head comprises: a bone-engagement member including a first patient-specific bone-engagement surface that is complementary and made to substantially mate and nest in only one position on a specific patient's humeral head; a registration member connected to the bone-engagement member including a second patient-specific bone engagement surface that is sized and made to substantially mate and nest in only one position with the specific patient's bicipital groove; a first protrusion extending from the registration member and having a first surgeon-engaging surface for manipulation by a surgeon; and a cut guide plate connected to and extending away from the registration member such that, upon the bone-engagement member mating and nesting with the specific patient's humeral head, the cut guide plate is spaced apart from the humeral head, wherein the cut guide plate defines an elongate slot.

Abstract: The embodiments described herein are configured to annotate engineering record (“ER”) data from database tables and their corresponding attributes for analytics tools consumption and to combine the database tables into one consumable entity that can expose a list of attributes to the customer. Attributes may be converted into standardized attributes based on analyzing attribute data types. This data can then be extracted by analytics tools via the common data reporting layer to generate one or more visualizations at a display of at a user's computer system. Such a solution requires far less technical understanding and implementation logic to enable users to focus on analytics rather than view building.

Abstract: A system, a method, and a computer program product for deriving target attribute values based on source attributes defined by a hierarchical data mode are disclosed. An attribute value derivation function to change a target attribute data value corresponding to a source attribute stored in a hierarchical data model and an instruction corresponding to the source attribute are provided. The attribute value derivation function is defined by an attribute value derivation header containing metadata describing hierarchical data model and an attribute value derivation instruction for deriving the target attribute based on the source attribute. Using the attribute value derivation function, a target attribute data value is derived. A user interface is generated to display the derived target attribute data value.