Patents by Inventor Wolfgang Wienen

Wolfgang Wienen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • New carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040077729
    Abstract: Carboxylic acid amides of general formula 1
    Type: Application
    Filed: July 21, 2003
    Publication date: April 22, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Uwe Ries, Henning Priepke, Wolfgang Wienen, Herbert Nar, Sandra Handschuh
  • Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
    Patent number: 6710055
    Abstract: Disubstituted bicyclic heterocycles of general formula I Ra—A—Het—B—Ar—E  (I). Compounds of general formula I, wherein E is an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: March 23, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Norbert Hauel, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Pharmaceutical compositions for the treatment of systemic inflammatory response syndrome
    Publication number: 20040023975
    Abstract: The present invention relates to the use of certain benzimidazoles for preparing a pharmaceutical composition for the treatment of systemic inflammatory response syndrome and particularly sepsis.
    Type: Application
    Filed: June 20, 2003
    Publication date: February 5, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Uwe Ries, Wolfgang Wienen, Uwe Schuehly
  • Benzimidazoles with antithrombotic activity
    Patent number: 6593355
    Abstract: Novel benzimidazoles having antithrombotic activity. Exemplary are: (a) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, (b) 2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, and (c) (R)-2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(isobutyloxycarbonylmethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: July 15, 2003
    Assignee: Boehringer Ingelehim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Modified aminoacids, pharmaceuticals containing these compounds and method for their production
    Publication number: 20030069231
    Abstract: The present invention relates to modified amino acids of general formula 1
    Type: Application
    Filed: April 10, 2002
    Publication date: April 10, 2003
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions
    Publication number: 20030045712
    Abstract: The present invention relates to new substituted aryl and heteroaryl derivatives of general formula 1
    Type: Application
    Filed: May 10, 2002
    Publication date: March 6, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Uwe Ries, Herbert Nar, Wolfgang Wienen, Jean-Marie Stassen
  • Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
    Publication number: 20030004181
    Abstract: Disubstituted bicyclic heterocycles of general formula I
    Type: Application
    Filed: July 10, 2002
    Publication date: January 2, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Norber Hauel, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Benzimidazoles with antithrombotic activity
    Publication number: 20030004356
    Abstract: Novel benzimidazoles having antithrombotic activity.
    Type: Application
    Filed: July 3, 2002
    Publication date: January 2, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Use of bicyclic heterocycles for the treatment and prevention of arterial thrombotic disease
    Publication number: 20020193404
    Abstract: The present invention relates to a method of treating and preventing arterial thrombotic diseases, comprising administering an effective amount of one of the compounds
    Type: Application
    Filed: May 2, 2002
    Publication date: December 19, 2002
    Inventors: Norbert Hauel, Wolfgang Wienen, Jean-Marie Stassen
  • Antithrombotic carboxylic acid amides
    Publication number: 20020183519
    Abstract: Carboxylic acid amides of formula 1
    Type: Application
    Filed: March 11, 2002
    Publication date: December 5, 2002
    Inventors: Herbert Nar, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Substituted aryl and heteroaryl derivatives, their production and their use as medicines
    Patent number: 6479524
    Abstract: Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, (b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, and (c) 4-[3-(2,5-dimethyl-4-isopropylcarbonyl-phenyl)propargyl-amino]benzamidine.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: November 12, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Iris Kauffmann-Hefner, Norbert Hauel, Uwe Ries, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Disubstituted bicyclic heterocycles, the preparation and the use thereof as pharmaceutical compositions
    Patent number: 6469039
    Abstract: New disubstituted bicyclic heterocycles of general formula Ra—A—Het—B—Ar—E  (I) Compounds of the above general formula I, wherein E denotes an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E denotes a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: October 22, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Norbert Hauel, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Antithrombotic compounds
    Publication number: 20020151534
    Abstract: Antithrombotic compounds of general formula 1
    Type: Application
    Filed: January 16, 2002
    Publication date: October 17, 2002
    Inventors: Uwe Joerg Ries, Henning Priepke, Herbert Nar, Jean-Marie Stassen, Wolfgang Wienen
  • Carboxylic acid amides having antithrombotic activity
    Publication number: 20020151595
    Abstract: Compounds with antithrombotic activity and factor Xa-inhibiting activity of the general formula: 1
    Type: Application
    Filed: January 17, 2002
    Publication date: October 17, 2002
    Inventors: Uwe Joerg Ries, Henning Priepke, Herbert Nar, Jean-Marie Stassen, Wolfgang Wienen
  • Benzimidazoles with antithrombotic activity
    Patent number: 6451832
    Abstract: Novel benzimidazoles having antithrombotic activity. Exemplary are: (a) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, (b) 2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, and (c) (R)-2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(isobutyloxycarbonylmethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: September 17, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
    Patent number: 6414008
    Abstract: New disubstituted bicyclic heterocycles of general formula Ra—A—Het—B—Ar—E  (I) Compounds of general formula I, wherein E is an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: July 2, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Norbert Hauel, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Modified aminoacids, pharmaceuticals containing these compounds and method for their production
    Patent number: 6344449
    Abstract: The present invention relates to modified amino acids of general formula wherein A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: February 5, 2002
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Modified amino acids, pharmaceuticals containing these compounds and method for their production
    Publication number: 20010036946
    Abstract: The present invention relates to modified amino acids of general formula 1
    Type: Application
    Filed: February 21, 2001
    Publication date: November 1, 2001
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Benzimidazoles with antithrombotic activity
    Publication number: 20010006977
    Abstract: Novel benzimidazoles having antithrombotic activity.
    Type: Application
    Filed: December 12, 2000
    Publication date: July 5, 2001
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Benzimidazoles having antithrombotic activity
    Patent number: 6248770
    Abstract: The present invention relates to new benzimidazoles of general formula wherein Ra to Rc, A, Ar and B are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof the prodrugs, the derivatives thereof which contain a group which is negatively charged under physiological conditions, instead of a carboxy group, and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I wherein Rc denotes a cyano group are valuable intermediates for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein Rc denotes one of the amidino groups mentioned in claim 1 which have valuable pharmacological properties, particularly an antithrombotic activity.
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: June 19, 2001
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Iris Kauffmann, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen