Patents by Inventor Wolfram Jochum

Wolfram Jochum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-human transgenic mammals and their use as a disease model
    Publication number: 20030229912
    Abstract: A non-human mammal that carries germline mutations in both the p53 and the Fos genes, methods for producing it and cell lines derived therefrom. The p53/Fos double knockout animal, in particular a mouse, is useful as a rhabdomyosarcoma disease model.
    Type: Application
    Filed: March 28, 2003
    Publication date: December 11, 2003
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Alexander Fleischmann, Erwin Wagner, Wolfram Jochum, Martin Radolf
  • Method for identifying compounds useful in the therapy of bone disorders
    Patent number: 6653064
    Abstract: The present invention relates to a screening method for identifying a substance for the treatment of bone disorders that are associated with reduced bone mass in which the substance is tested for its ability to upregulate the expression of Fra-1 or to modulate the expression of a Fra-1 target gene in osteoblasts where the upregulation or modulation results in an increased bone formation in vivo. The identified osteoinductive compounds and DNA molecules encoding biologically active Fra-1 molecules can be used for the therapy of bone disorders characterized by a circumscribed or systemic reduction of bone mass.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: November 25, 2003
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Wolfram Jochum, Jean-Pierre David, Koichi Matsuo, Erwin F. Wagner