Abstract: A breast imaging system comprises: a wide area tissue receptacle adapted to be coupled to an imaging apparatus, the imaging apparatus having an imaging volume, the wide area tissue receptacle defining a wide area tissue volume, the wide area tissue volume at least partially intersecting the imaging volume to form a wide area tissue imaging volume, the wide area tissue receptacle having an opening that is sufficiently wide to accept an entire breast into the wide area tissue receptacle, the wide area tissue receptacle having a sealing interface below the opening adapted to create a seal between tissue and the wide area tissue receptacle; and a pump coupled to the wide area tissue receptacle, the pump adapted to apply negative pressure to the wide area tissue volume to form the seal between the sealing interface and the tissue, and the pump further adapted to apply negative pressure to pull the breast into the wide area tissue volume, a diagnostic volume being defined as a portion of the breast intersecting the

Abstract: An image reconstructor to: receive projection space data; compute one or more measured transformed pixels; compute one or more predicted transformed pixels; compute first pixel innovation result data; compute second pixel innovation result data; compute preliminary transformed object update data; compute a transformed object voxel density update estimate; add the transformed object voxel density update estimate to a corresponding transformed preceding voxel data estimate; and reconstruct an object space image representing the object under observation using the transformed density estimate.

Abstract: An image reconstructor to: receive projection space data; compute one or more measured transformed pixels; compute one or more predicted transformed pixels; compute first pixel innovation result data; compute second pixel innovation result data; compute preliminary transformed object update data; compute a transformed object voxel density update estimate; add the transformed object voxel density update estimate to a corresponding transformed preceding voxel data estimate; and reconstruct an object space image representing the object under observation using the transformed density estimate.

Abstract: An image reconstructor to: receive projection space data; compute one or more measured transformed pixels; compute one or more predicted transformed pixels; compute first pixel innovation result data; compute second pixel innovation result data; compute preliminary transformed object update data; compute a transformed object voxel density update estimate; add the transformed object voxel density update estimate to a corresponding transformed preceding voxel data estimate; and reconstruct an object space image representing the object under observation using the transformed density estimate.

Abstract: A breast imaging system comprises: a wide area tissue receptacle adapted to be coupled to an imaging apparatus, the imaging apparatus having an imaging volume, the wide area tissue receptacle defining a wide area tissue volume, the wide area tissue volume at least partially intersecting the imaging volume to form a wide area tissue imaging volume, the wide area tissue receptacle having an opening that is sufficiently wide to accept an entire breast into the wide area tissue receptacle, the wide area tissue receptacle having a sealing interface below the opening adapted to create a seal between tissue and the wide area tissue receptacle; and a pump coupled to the wide area tissue receptacle, the pump adapted to apply negative pressure to the wide area tissue volume to form the seal between the sealing interface and the tissue, and the pump further adapted to apply negative pressure to pull the breast into the wide area tissue volume, a diagnostic volume being defined as a portion of the breast intersecting the

Abstract: An image reconstructor to: receive projection space data; compute one or more measured transformed pixels; compute one or more predicted transformed pixels; compute first pixel innovation result data; compute second pixel innovation result data; compute preliminary transformed object update data; compute a transformed object voxel density update estimate; add the transformed object voxel density update estimate to a corresponding transformed preceding voxel data estimate; and reconstruct an object space image representing the object under observation using the transformed density estimate.

Abstract: A system comprising: one or more transmitters to transmit an excitation energy into an object under observation; one or more detectors to generate projection space data encoding an energy received by the one or more detectors in response to the transmitted excitation energy into the object under observation; a controller to control the one or more transmitters to transmit the excitation energy and the one or more detectors to generate the projection space data; and an image reconstructor to receive the projection space data and to process the projection space data by: computing a first quantity characterizing a difference between the projection space data and predicted projection data; computing a second quantity corresponding to at least one impulse response, each impulse response corresponding to a reference voxel of unit-intensity; computing an update value using the first quantity and an inverted function of the second quantity; and reconstructing an object space image representing the object under observ

Abstract: A system including: one or more transmitters to transmit an excitation energy into an object under observation; one or more detectors to generate projection space data encoding an energy received by the one or more detectors in response to the transmitted excitation energy into the object under observation; a controller to control the one or more transmitters to transmit the excitation energy and the one or more receivers to generate the projection space data; and an image reconstructor to receive the projection space data and to process the projection space data by: computing a first quantity characterizing a difference between the projection space data and predicted projection data; computing a second quantity corresponding to at least one impulse response, each impulse response corresponding to a reference voxel of unit-intensity; computing an update value using the first quantity and an inverted function of the second quantity; and reconstructing an object space image representing the object under observa

Abstract: A system comprising: one or more transmitters to transmit an excitation energy into an object under observation; one or more detectors to generate projection space data encoding an energy received by the one or more detectors in response to the transmitted excitation energy into the object under observation; a controller to control the one or more transmitters to transmit the excitation energy and the one or more receivers to generate the projection space data; and an image reconstructor having at least one processor to receive the projection space data and to process the projection space data by: computing a first quantity characterizing a difference between the projection space data and predicted projection data, wherein the difference between the projection space data and predicted projection data is associated with a projection gain; recording, in a data storage device, a first data encoding the difference; computing a revised first quantity based on recorded first data from preceding iterations; computin

Abstract: A system comprising: one or more transmitters to transmit an excitation energy into an object under observation; one or more detectors to generate projection space data encoding an energy received by the one or more detectors in response to the transmitted excitation energy into the object under observation; a controller to control the one or more transmitters to transmit the excitation energy and the one or more detectors to generate the projection space data; and an image reconstructor to receive the projection space data and to process the projection space data by: computing a first quantity characterizing a difference between the projection space data and predicted projection data; computing a second quantity corresponding to at least one impulse response, each impulse response corresponding to a reference voxel of unit-intensity; computing an update value using the first quantity and an inverted function of the second quantity; and reconstructing an object space image representing the object under observ