Patents by Inventor Wolter Ten Hoeve
Wolter Ten Hoeve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160151505Abstract: The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.Type: ApplicationFiled: May 16, 2012Publication date: June 2, 2016Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Marc Stefan Robillard, Wolter Ten Hoeve, Ronny Mathieu Versteegen, Raffaella Rossin, Freek Johannes Maria Hoeben
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Publication number: 20160106859Abstract: The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.Type: ApplicationFiled: December 30, 2015Publication date: April 21, 2016Inventors: MARC STEFAN ROBILLARD, HENDRICUS MARIE JANSSEN, WOLTER TEN HOEVE, RONNY MATHIEU VERSTEEGEN, RAFFAELLA ROSSIN
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Publication number: 20150344514Abstract: Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactive components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine.Type: ApplicationFiled: November 22, 2013Publication date: December 3, 2015Inventors: Marc Stefan Robillard, Ronny Mathieu Versteegen, Wolter ten Hoeve, Raffaella Rossin
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Publication number: 20140199331Abstract: The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.Type: ApplicationFiled: May 16, 2012Publication date: July 17, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Marc Stefan Robillard, Hendricus Marie Janssen, Wolter Ten Hoeve, Ronny Mathieu Versteegen
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Publication number: 20140093522Abstract: The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.Type: ApplicationFiled: May 16, 2012Publication date: April 3, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Marc Stefan Robillard, Hendricus Marie Janssen, Wolter Ten Hoeve, Ronny Mathieu Versteegen, Raffaella Rossin
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Publication number: 20130189184Abstract: Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.Type: ApplicationFiled: October 11, 2011Publication date: July 25, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Johan Lub, Wolter Ten Hoeve, Raffaella Rossin, Sandra Martina Van Den Bosch, Marc Stefan Robillard
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Patent number: 7402707Abstract: The synthesis of a precursor oligocene, particularly pentacene, is a two-step process. In the first step the Diels-Alder adduct of the a,b-dihydro-a,b-etheno-oligocene with a 1,1-dialkoxy-cyclopentadiene is formed. In the second step this Diels-Alder adduct is converted into the precursor oligocene, in that first the corresponding keto-compound is formed, which may be eliminated thereafter. The resulting precursor oligocene can be converted to the oligocene with a heat treatment, particularly after providing a solution hereof on a substrate. It is suitable for use as semiconductor material in a thin-film transistor. Formula (I).Type: GrantFiled: March 17, 2004Date of Patent: July 22, 2008Assignee: Koninklijke Philips Electronics N.V.Inventors: Wolter Ten Hoeve, Bart-Hendrik Huisman
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Patent number: 7361716Abstract: A polymer comprising structural units of the formula I is prepared according to a novel method, in which the starting compound R1 ‘S—(CHR’2)—Ar—(CHR2)—SR1 is polymerized with a base, preferably in an aprotic solvent. The polymer comprises 50 to 1000 structural units of the formula I. The solution comprising the polymer thus prepared has a lower viscosity than a solution of a similar polymer with a greater chain length. The solution comprising the polymer thus prepared may be applied as a layer on a substrate. Electronic components with layers prepared with the polymer of the invention show better properties.Type: GrantFiled: May 25, 2001Date of Patent: April 22, 2008Assignee: Koninklijke Philips Electronics N.V.Inventors: Wolter Ten Hoeve, Margaretha Maria De Kok, Bart-Hendrik Huisman, Peter Tobias Herwig, Albert Jos Jan Marie Van Breemen
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Publication number: 20060166409Abstract: The synthesis of a precursor oligocene, particularly pentacene, is a two-step process. In the fist step the Diels-Alder adduct of the a,b-dihydro-a,b-etheno-oligocene with a 1,1-dialkoxy-cyclopentadiene is formed. In the second step this Diels-Alder adduct is converted into the precursor oligocene, in that first the corresponding keto-compound is formed, which may be eliminated thereafter. The resulting precursor oligocene can be converted to the oligocene with a heat treatment, particularly after providing a solution hereof on a substrate. It is suitable for use as semiconductor material in a thin-film transistor. Formula (I).Type: ApplicationFiled: March 17, 2004Publication date: July 27, 2006Applicant: Koninklijke Philips Electronics N.V.Inventors: Wolter Ten Hoeve, Bart-Hendrik Huisman
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Publication number: 20030027963Abstract: A polymer comprising structural units of the formula I is prepared according to a novel method, in which the starting compound R1 ‘S—(CHR’2) —Ar— (CHR2)—SR1 is polymerized with a base, preferably in an aprotic solvent. The polymer comprises 50 to 1000 structural units of the formula I. The solution comprising the polymer thus prepared has a lower viscosity than a solution of a similar polymer with a greater chain length. The solution comprising the polymer thus prepared may be applied as a layer on a substrate. Electronic components with layers prepared with the polymer of the invention show better properties.Type: ApplicationFiled: January 24, 2002Publication date: February 6, 2003Inventors: Wolter Ten Hoeve, Margaretha Maria De Kok, Bart-Hendrik Huisman, Peter Tobias Herwig, Albert Jos Jan Marie Van Breemen
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Publication number: 20020001732Abstract: A polymer electroluminescent device (1) comprises an electroluminescent layer (7) of a poly(1,4-phenylenevinylene) having aryl-1,4-phenylene units, where the aryl group is a phenyl, naphthyl or biphenylyl group. Using such a poly(1,4-phenylenevinylene) has the effect that the light emitted by the polymer electroluminescent device has no or at least a reduced tendency to change color when driven the device is and/or kept at an elevated ambient temperature of, for example, 70° C. The poly(1,4-phenylenevinylene)s having aryl-1,4-phenylene units are prepared using aryl-bishalomethylbenzenes as an intermediate compound.Type: ApplicationFiled: April 10, 1998Publication date: January 3, 2002Inventors: HERMANNUS F.M. SCHOO, ROBERT J.C.E. DEMANDT, COEN T.H.F. LIEDENBAUM, HANS WIJNBERG, WOLTER TEN HOEVE, KARIN J. SPOELSTRA
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Patent number: 6184540Abstract: The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.Type: GrantFiled: February 12, 1999Date of Patent: February 6, 2001Assignee: U.S. Philips CorporationInventors: Knut H. Chmii, Adam R. Brown, Dagobert M. De Leeuw, Edsko E. Havinga, Anita Pomp, Wolter Ten Hoeve, Hans Wijnberg
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Patent number: 6124475Abstract: The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.Type: GrantFiled: March 16, 1998Date of Patent: September 26, 2000Assignee: U.S. Philips CorporationInventors: Knut H. Chmil, Adam R. Brown, Dagobert M. De Leeuw, Edsko E. Havinga, Anita Pomp, Wolter Ten Hoeve, Hans Wijnberg
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Patent number: 5919951Abstract: The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.Type: GrantFiled: September 22, 1998Date of Patent: July 6, 1999Assignee: U.S. Philips CorporationInventors: Knut H. Chmii, Adam R. Brown, Dagobert M. De Leeuw, Edsko E. Havinga, Anita Pomp, Wolter Ten Hoeve, Hans Wijnberg
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Patent number: 5677432Abstract: A compound useful for forming immunoconjugates used in the detection of organophosphate pesticides is provided. The compound has the formula ##STR1## wherein X is selected from the group consisting of R--O--, R--S-- and R--NH--, where R is an optionally substituted aromatic or heterocyclic group, or an optionally substituted alkyl or alkenyl group;Y is O or S;R.sup.1 is H or alkyl; andR.sup.2 is a group of the formula --(CH.sub.2).sub.n -- wherein n is an integer of from 1 to 10, or branched chain alkylene, or a group of the formula R.sup.3 --O--R.sup.4 wherein R.sup.3 and R.sup.4 are both or straight or branched chain alkylene;or a salt or ester thereof.Type: GrantFiled: August 19, 1994Date of Patent: October 14, 1997Assignee: The Horticulture and Food Research Institute of New Zealand LimitedInventors: William Thomas Jones, Hans Wynberg, Wolter Ten Hoeve
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Patent number: 5463050Abstract: The present invention is concerned with a method for the preparation of a compound of the general formula 2 ##STR1## by reaction of a compound of the formula 3Ar--Y (3)with a compound of the general formula 4 ##STR2## wherein Ar means a (hetero)aryl group, preferably selected from phenyl, naphtyl, furyl, thienyl, pyridyl, bicylic heteroaryl and tricyclic heteroaryl, which (hetero)aryl group is optionally sustituted with one to five non-strongly-electron-withdrawing substituents;M is a metal from the groups I or II of the periodic table;R.sub.12 is an electronegative group; andis 0 or 1.The invention also relates to compounds prepared according to this method and to new substituted aryl(homo)piperazines.Type: GrantFiled: February 12, 1993Date of Patent: October 31, 1995Assignee: Duphar International Research, B.V.Inventors: Wolter Ten Hoeve, Jantje R. G. Thiecke, Hans Wynberg, Chris G. Kruse
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Patent number: 5380807Abstract: Polycondensation of, for example, squaric acid with a benzodihydropyrrole, benzodithiazole, neocuproine, terthienyl or an aromatic diamine gives a semiconductive alternating copolymer having a small band gap. It is alternatively possible to use croconic acid or 5,6-dihydroxy-5-cyclohexene-1,2,3,4-tetraone instead of squaric acid.Type: GrantFiled: January 8, 1993Date of Patent: January 10, 1995Assignee: U.S. Philips CorporationInventors: Edsko E. Havinga, Wolter Ten Hoeve, Hans Wijnberg
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Patent number: 5252191Abstract: The invention relates to a method for the photochemical isomerization of organic compounds, in particular for the photochemical conversion of tachysterol compounds into previtamin D compounds and of trans-vitamin D compounds into cis-vitamin D compounds, under the influence of radiation, by exposing a solution of the organic compound to be converted in the presence of a non-polymeric photosensitizer to light with approx. 300-1,000 nm wavelength, and by then isolating the resulting product, wherein a substituted thiophene derivative having a substantial absorption in said wavelength region is used as the photosensitizer. The invention also relates to a new photosensitizer to be used for said isomerization reaction.Type: GrantFiled: April 24, 1991Date of Patent: October 12, 1993Assignee: Duphar International Research B.V.Inventors: Louis F. Pauli, Alphons Dufourny, Robert B. Koolstra, Hans Wynberg, Wolter Ten Hoeve
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Patent number: 5006729Abstract: Nonlinear optical compound, nonlinear optical medium, method of manufacturing a nonlinear optical medium and device for doubling the frequency of a light wave. The invention relates to a nonlinear optical medium and a device comprising such a nonlinear optical medium which can be suitably used to double the frequency of red light, while forming blue light. The nonlinear optical medium comprises a polymer matrix and nonlinear optical compounds which contain a substituted sulphone group as the electron-acceptor group.Type: GrantFiled: April 24, 1990Date of Patent: April 9, 1991Assignee: U.S. Philips CorporationInventors: Egbert W. Meijer, Wolter Ten Hoeve, Sjef Nijhuis, Gerardus L. J. A. Rikken, Edsko E. Havinga
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Patent number: 4885375Abstract: Optically active 3-(4-methoxyphenyl)glycidic acid alkyl esters of high enantiomeric purity can be prepared through optical resolution of a racemic or optically enriched sample of a 3-(4-methoxyphenyl) glycidic acid. The alkali metal salt of the acid, generated in situ by hydrolysis of the corresponding alkyl ester with an alkali metal hydroxide is contacted with a suitable resolving agent such as an optically pure amine to form the corresponding diastereomeric salts. The desired diastereomeric salt is separated from the mixture and transformed to an alkali metal salt, which optionally without isolation is converted into the desired alkyl ester of high enantiomeric purity.Type: GrantFiled: May 18, 1988Date of Patent: December 5, 1989Assignee: Marion Laboratories, Inc.Inventors: Hans Wynberg, Wolter ten Hoeve