Patents by Inventor Won-Jea Cho

Won-Jea Cho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-amide derivative and use thereof
    Patent number: 10064843
    Abstract: The present invention relates to a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a method of preparation thereof; and a pharmaceutical composition for preventing or treating diseases caused by hepatitis C virus infection and health functional food for preventing or ameliorating diseases caused by hepatitis C virus infection, containing the bis-amide derivative compound or a pharmaceutically acceptable salt thereof as an active ingredient. The novel bis-amide derivative compound of the present invention, particularly WJCPA-126, specifically binds to the catalytic site of CypA to effectively inhibit the activity of an isomerase, and the duration of the inhibitory effect can be increased because WJCPA-126 binds to CypA with high binding affinity exhibiting a low dissociation rate (Koff). Accordingly, WJCPA-126 has nontoxic and non-immunosuppressive characteristics and can effectively inhibit HCV replication in vitro and in vivo model systems.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: September 4, 2018
    Assignee: University-Industry Cooperation Group of Kyung Hee University
    Inventors: Sung Soo Kim, Won Jea Cho
  • NOVEL BIS-AMIDE DERIVATIVE AND USE THEREOF
    Publication number: 20160297751
    Abstract: The present invention relates to a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a method of preparation thereof; and a pharmaceutical composition for preventing or treating diseases caused by hepatitis C virus infection and health functional food for preventing or ameliorating diseases caused by hepatitis C virus infection, containing the bis-amide derivative compound or a pharmaceutically acceptable salt thereof as an active ingredient. The novel bis-amide derivative compound of the present invention, particularly WJCPA-126, specifically binds to the catalytic site of CypA to effectively inhibit the activity of an isomerase, and the duration of the inhibitory effect can be increased because WJCPA-126 binds to CypA with high binding affinity exhibiting a low dissociation rate (Koff). Accordingly, WJCPA-126 has nontoxic and non-immunosuppressive characteristics and can effectively inhibit HCV replication in vitro and in vivo model systems.
    Type: Application
    Filed: September 5, 2014
    Publication date: October 13, 2016
    Inventors: Sung Soo Kim, Won Jea Cho
  • 5, 6, or 7-substituted -3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof
    Patent number: 8314123
    Abstract: The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: November 20, 2012
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Young Bok Lee, Chang Ho Ahn, Won-Jea Cho
  • 5, 6, or 7-SUBSTITUTED -3-(HETERO) ARYLISOQUINOLINAMINE DERIVATIVES AND THERAPEUTIC USE THEREOF
    Publication number: 20120029012
    Abstract: The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
    Type: Application
    Filed: October 7, 2011
    Publication date: February 2, 2012
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: YOUNG B. LEE, Chang H. Ahn, Won-Jea Cho
  • 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof
    Patent number: 8034829
    Abstract: The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: October 11, 2011
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Young B. Lee, Chang H. Ahn, Won-Jea Cho
  • 5, 6, or 7-Substituted - 3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof
    Publication number: 20080182871
    Abstract: The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
    Type: Application
    Filed: November 15, 2007
    Publication date: July 31, 2008
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: Young B. Lee, Chang H. Ahn, Won-Jea Cho