Abstract: The porosome is the main secretory structure of the eukaryotic cell. Presented herein are compositions and methods for the control and regulation of the porosome structure. Including a method of porosome-associated-protein and interacting small molecule identification; usage of small molecules targeted to one or more porosome proteins; compositions and usages of nanobodies coupled with small molecules; the reconstitution of porosomes; and the creation and usage of artificial porosome structures.

Abstract: A cell penetrating peptide (CPP) according to the present invention is a novel cationic cell penetrating peptide that can effectively transport a biologically active molecule by passing through a cell membrane even when a biologically active molecule is bound thereto, and compared with conventional CPPs, it has excellent cell permeability enabling the transport of a biologically active molecule into cells, and the delivered biologically active molecule may effectively maintain its activity in cells. Accordingly, the CPP of the present invention may be very useful in various fields including cosmetics, diagnostics, drug delivery systems, recombinant protein vaccines, DNA/RNA therapeutics, and gene and protein therapy.

Abstract: An apparatus and a method for predicting an amount of temperature change of a target zone are provided. The method includes collecting a plurality of base information, and calculating base relationship information between an indoor/outdoor temperature difference of the target zone and an amount of temperature change of the target zone on the basis of the plurality of base information. Each of the plurality of base information is information on the amount of temperature change of the target zone according to the indoor/outdoor temperature difference of the target zone during a late night time section, and the late night time section is set on the basis of at least one of activity schedule information, a sunrise time point, and a sunset time point of the target zone.

Abstract: A display device includes: a pixel component including pixels; a timing controller configured to calculate a load variation between previous input grayscale values corresponding to a previous frame and current input grayscale values corresponding to a current frame; a current sensor configured to sense a current flowing through the pixels during the current frame and generate a global current value for the sensed current, store time points at which the global current value becomes equal to preset threshold current values, respectively, and generate a global current variation rate corresponding to a section between the stored time points of the current frame; and a scale factor provider configured to control a scale factor in a period of the current frame in the case where the load variation is equal to or more than a reference load variation.

Abstract: The present disclosure relates to a radar system including a pulse Doppler radar. A method of removing clutter according to the present disclosure includes obtaining chirp rate information on a chirp rate applied to a transmission signal of the pulse Doppler radar, determining a reference Doppler frequency for removing a clutter signal by considering the chirp rate information, and removing a signal having a frequency less than or equal to the reference Doppler frequency.

Abstract: A display device includes: a pixel component including pixels; a timing controller configured to calculate a load variation between previous input grayscale values corresponding to a previous frame and current input grayscale values corresponding to a current frame; a current sensor configured to sense a current flowing through the pixels during the current frame and generate a global current value for the sensed current, store time points at which the global current value becomes equal to preset threshold current values, respectively, and generate a global current variation rate corresponding to a section between the stored time points of the current frame; and a scale factor provider configured to control a scale factor in a period of the current frame in the case where the load variation is equal to or more than a reference load variation.

Abstract: A display device of the disclosure includes a grayscale converter which converts input grayscales into output grayscales based on a scale factor, a data driver which converts the output grayscales into data voltages, a plurality of pixels which receives the data voltages and displays an image based on the data voltages, and a current sensor which provides a sensing current by sensing a first power current supplied to the plurality of pixels to display the image. When a load corresponding to the input grayscales is greater than a minimum load, the grayscale converter adjusts a change amount of the scale factor based on a current difference between a target current corresponding to the load and the sensing current.

Abstract: A method for decoding an image based on an intra prediction, comprising: obtaining a first prediction pixel of a first region in a current block by using a neighboring pixel adjacent to the current block; obtaining a second prediction pixel of a second region in the current block by using the first prediction pixel of the first region; and decoding the current block based on the first and the second prediction pixels.

Abstract: An image sensing device includes a pixel array including a plurality of pixels, each of pixels configured to generate a pixel signal corresponding to intensity of incident light, and a plurality of grid structures, each grid structure disposed to overlap with a boundary between adjacent pixels among the plurality of pixels and configured to include an air layer so as to optically isolate the adjacent pixels. Each of the grid structures includes regions that form a cross shape.

Abstract: An embodiment parallel cell based mobility production system includes a front serial production line which is composed of one or more cells arranged in series and through which vehicles of various types sequentially pass to be processed, a parallel production line provided with a plurality of cells arranged in a matrix form, and a rear serial production line in which the vehicles of various types passed through the parallel production line are sequentially fed.

Abstract: A display device includes a plurality of pixels grouped into blocks divided into block rows extending in a first direction and arranged in a second direction, wherein each block includes two or more pixels connected to a first power source line, and each pixel is assigned with a grayscale value in a range of grayscale values that is divided into a plurality of grayscale sections; and a first power source voltage adjuster selecting a reference block row, and determining a magnitude of a first power source voltage supplied to the first power source line based on a number of blocks in the reference block row having a grayscale section that is same as a maximum grayscale section of the reference block row. The maximum grayscale section corresponds to a grayscale section that includes a largest grayscale value having a grayscale value ratio greater than a minimum ratio.

Abstract: A method of treating intestinal, gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

Abstract: An integrated control apparatus for driving a vehicle is provided. The apparatus includes a lever housing mounted in an interior space of the vehicle; a joystick lever coupled to the lever housing and configured to be rotatable in a forward-backward direction and a leftward-rightward direction; and a gentle acceleration lever coupled to the joystick lever and configured to be rotatable in the forward-backward direction. When the gentle acceleration lever is operated, a gentle acceleration signal of the vehicle is generated, and when the joystick lever is operated, one of a sudden acceleration signal, a deceleration signal, a steering signal, or a braking signal of the vehicle is generated.

Abstract: The present invention relates to a use of a caspase inhibitor for alleviating or treating osteoarthritis.

Abstract: Disclosed are a micro fiber and a method of manufacturing the micro fiber are proposed. The micro fiber may be manufactured by controlling thickness and Young's modulus thereof using hollow fiber.

Abstract: DRG2 of the present invention is a predictor of a therapeutic response or prognosis of a cancer patient with respect to an agent for cancer immunotherapy in PD-L1 positive cancer and is a biomarker that can be used in companion diagnosis for determination of the administration of an agent for cancer immunotherapy in PD-L1 positive cancer. By determining whether to administer an agent for cancer immunotherapy through the present invention, the agent for cancer immunotherapy can be selectively administered to a patient who will show a therapeutic response, and thus is expected to treat PD-L1 positive cancer more effectively.

Abstract: Provided herein may be a display device. The display device may include a display panel including a plurality of unit blocks disposed in a display area, the plurality of unit blocks including a first area displaying a logo or a banner, a second area having largest load value and a third area disposed between the first area and the second area, a display panel driver configured to generate data voltages based on input image data, and a zonal compensator configured to receive the input image data, to calculate load values of the input image data for the plurality of unit blocks, respectively, and to control luminance of each of the first area and the third area based on a location difference between the first area and the second area and a load value difference between the first area and the second area.

Abstract: Disclosed are improved peptides for inhibiting angiogenesis, Ac-RLYE (SEQ ID NO: 1) and R(D)LYE (SEQ ID NO: 6), and a composition for the prevention and treatment of cancers and diseases related to angiogenesis comprising the peptides as an active ingredient. A peptide for inhibiting angiogenesis is disclosed wherein the L-Arg of an N-terminal is acetylated in a peptide consisting of an amino acid sequence of Arg-Leu-Tyr-Glu (SEQ ID NO: 1). A peptide for inhibiting angiogenesis is disclosed wherein L-Arg is substituted with D-Arg in a peptide consisting of the amino acid sequence of Arg-Leu-Tyr-Glu (SEQ ID NO: 6). Methods for using a composition comprising the peptides as active ingredients for the prevention or treatment of diseases (cancer, diabetic retinopathy or senile macular degeneration) caused by excessive angiogenesis are also disclosed. The peptides have a long half-life and are excellent in VEGF-induced angiogenesis inhibitory effect.

Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.