Abstract: Disclosed herein include systems, methods, compositions, and kits for full-length whole transcriptome analysis (WTA). Some embodiments comprise 5?-based, 3?-based, and internal-based gene expression profiling. Immune repertoire profiling methods are also provided in some embodiments.

Abstract: A method of treating a substrate treats a substrate by using a substrate treating apparatus that includes a main supply line connected to a humidified gas supply line and a dry gas supply line, having a first region in which a first heater is installed, and a second region located downstream of the first region. The method includes a heating operation of heating the second region with the dry gas heated in the first region by supplying the dry gas into the main supply line in a state where the first heater is controlled to heat the first region; and a substrate treating operation of supplying the humidified gas into the main supply line after the heating operation and allowing the humidified gas to pass through the first region and the second region and to be supplied into the treatment space to treat the substrate disposed in the treatment space.

Abstract: Disclosed is a display device mounted on a vehicle, the display device including a display module, a back cover surrounding side and rear surfaces of the display module, the back cover having a cover bracket formed by protruding from a lower side of a rear surface thereof, a printed circuit board connected to the display module and having one surface covered by the cover bracket, and a bottom cover covering the other surface of the printed circuit board and coupled to the cover bracket, wherein the printed circuit board is positioned vertical to the rear surface of the back cover, whereby watertight performance of the display device may be improved by covering a printed circuit board through a cover bracket formed to protrude from a back cover and a bottom cover coupled to the cover bracket.

Abstract: Disclosed herein include systems, methods, compositions, and kits for reducing non-specific noise-causing oligonucleotides in library preparations. Capture particles present in PCR reactions that are derived from partitions that did not contain a cell (e.g., noise capture particles) provide a significant source of non-specific nucleic acid and noise in single cell multiomics library preparations. In some embodiments of the methods provided herein, said noise capture particles are removed by a variety of approaches.

Abstract: Disclosed herein include systems, methods, compositions, and kits for associating single cell sequencing data with imaging data (e.g., phenotypic data). In some embodiments, particle indexing oligonucleotides are associated with reference particles. Reference particles can comprise one or more detectable moieties. The particle indexing oligonucleotide can comprise a particle type identifier (PTI) and a unique particle identifier (UPI). The PTI and the UPI can be employed to identify of the imaged partition from which a sequenced nucleic acid target molecule originated.

Abstract: A camera module is provided. The lens module includes a substrate on which an image sensor is disposed; a lens module, disposed in an inner housing of the camera module, and further disposed on a first surface of the substrate; and a heat transfer member, including a thermoelectric element, and disposed on a second surface of the substrate, wherein the substrate includes a heat transfer portion, wherein the heat transfer portion includes a plurality of holes which penetrate the substrate, and wherein a heat transfer material is disposed in the plurality of holes.

Abstract: Disclosed is a substrate processing method including: a substrate loading operation of loading a substrate into a processing space provided by a body; a heating operation of placing the substrate, which has been loaded into the processing space, on a heating chuck and heating the substrate; and an atmosphere changing operation of changing an atmosphere of the processing space, in which the atmosphere changing operation includes: a gas discharging operation of injecting atmosphere changing gas in a state where the substrate is located closer to a baffle than in the heating operation, in which the baffle is provided on a top side of the heating chuck to face the heating chuck and injects the atmosphere changing gas; and a substrate lowering operation of lowering and placing the substrate onto the heating chuck while maintaining the injection of the atmosphere changing gas.

Abstract: Disclosed are an electronic device, including a memory configured to store parameters of an electrochemical model corresponding to a battery, a sensor configured to measure a voltage of the battery, and a processor configured to determine a first cumulative state of charge (SOC) correction amount at a partially discharged point in time at which a SOC of the battery is corrected by a corrector for reducing a voltage difference between an estimated voltage of the electrochemical model and the measured voltage of the battery, estimate a second cumulative SOC correction amount at a fully discharged point in time based on the first cumulative SOC correction amount and a SOC correction amount prediction curve, and update an aging parameter of the electrochemical model based on the second cumulative SOC correction amount.

Abstract: An electronic apparatus includes: a battery; a first calculator configured to obtain sensing data of the battery using a sensor, determine first state information of the battery using the obtained sensing data and a first battery model, and preprocess the obtained sensing data; and a second calculator configured to receive the preprocessed sensing data from the first calculator, determine an aging state of the battery using a second battery model and the received sensing data, update a parameter of the first battery model based on the determined aging state, and transmit the updated parameter to the first calculator.

Abstract: Provided are a compound capable of degrading a target protein using ubiquitin and having a targeted protein binding moiety (TBM) structure binding to a target protein or polypeptide and a ubiquitin binding moiety (UBM) structure to which ubiquitin is bound, wherein the compound can be induced to polyubiquitination by the UBM structure present in the compound, and thus have an advantage of becoming a protein degrader capable of degrading a target protein or polypeptide.

Abstract: A driving torque distribution apparatus has a rapid response speed by applying a ball ramp device including a ball which is rolling-supported between a worm wheel rotated by a worm gear and a cam ring fixed in a rotation direction, and configured to generate an axial directional pressurizing force in conjunction with the rotation of the worm wheel, as first and second operation units to control first and second clutch units, and is configured so that an axial directional load due to pressurizing forces of the first and second operation units is canceled within each drum by a snap ring and a spacer fixed to internal and external sides of each drum of the first and second clutch units, preventing an interface between axial directional loads acting on the first and second clutch units.

Abstract: Disclosed are an apparatus and a method for treating a substrate, and more particularly, an apparatus and a method for heat treating a substrate. The apparatus includes: a heating unit provided in the inner space, and providing a treatment space in which a heating process of the substrate is performed; a transfer plate positioned within the inner space, and movable between an inner position for loading the substrate into the treatment space or for unloading the substrate from the treatment space and an outer position provided outside the heating unit; and a gas injection unit positioned within the inner space, and for injecting atmosphere gas toward the substrate at the outer position.

Abstract: Disclosed herein include systems, methods, compositions, and kits for determining the spatial location and copy number of targets (e.g., nucleic acid targets, cellular component targets) in a sample. There are provided, in some embodiments, substrates comprising a plurality of spatial regions. A plurality of oligonucleotide barcodes can be associated with each of the spatial regions and can comprise a predetermined spatial label. Oligonucleotide barcodes of the same spatial region can comprise the same spatial label, and oligonucleotide barcodes of the different spatial regions can comprise different spatial labels. The method can comprise contacting the substrate with a sample such that each distinct spatial region contacts a distinct spatial location of the sample. The method can comprise in situ extension (e.g., reverse transcription) of the oligonucleotide barcodes.

Abstract: Disclosed herein include systems, methods, compositions, and kits for full-length whole transcriptome analysis (WTA). Some embodiments comprise 5?-based, 3?-based, and internal-based gene expression profiling. In some embodiments, nucleic acid targets (e.g., mRNAs) are initially barcoded on the 3? end with the first plurality of oligonucleotide barcodes and subsequently barcoded on the 5? end following a template switching reaction and intermolecular hybridization with a second plurality of oligonucleotide barcodes and extension. In some embodiments, extended barcoded nucleic acid molecules are contacted with a transposome and tagmentation products are barcoded with a third plurality of oligonucleotide barcodes. Immune repertoire profiling methods are also provided in some embodiments.

Abstract: A method and apparatus for estimating a state of a battery. The method includes obtaining a measured voltage of a battery from a sensor connected to the battery, obtaining an estimated voltage of the battery from an electrochemical model stored in a memory, estimating an aging variation of the battery based on the measured voltage and the estimated voltage, and updating an aging parameter of the electrochemical model using the aging variation.

Abstract: Disclosed herein include systems, methods, compositions, and kits for performing targeted single cell mRNA sequencing assays. Capture oligonucleotides capable of specifically binding to target nucleic acid species are provided in some embodiments. Depletion oligonucleotides capable of specifically binding to undesirable nucleic acid species are provided in some embodiments. The method can comprise random priming and extension of barcoded transcripts followed by one or more enrichment and/or depletion steps using said capture oligonucleotides and/or depletion oligonucleotides. Immune repertoire profiling methods are also provided in some embodiments.

Abstract: Antibodies attached to oligonucleotides can bind to proteins of cells. These oligonucleotides can be released and captured by solid support oligonucleotides attached to solid supports. A detection oligonucleotide can hybridize to the captured oligonucleotides forming a sandwich of solid support oligonucleotide-captured oligonucleotide-detection oligonucleotide. The detection oligonucleotide and the captured oligonucleotides it binds to can be quantified by, for example, the fluorescent intensity of second detectable moieties (e.g., dye(s)) on the detection oligonucleotide. The identity of the protein quantified can be determined by, for example, the fluorescent intensity of first detectable moieties (e.g., dye(s)) on the solid support with the sandwich of solid support oligonucleotide-captured oligonucleotide-detection oligonucleotide.

Abstract: Disclosed herein include systems, methods, compositions, and kits for preserving and/or recovering RNA from fixed and/or permeabilized cells, for example for single cell analysis. In some embodiments, the fixed and/or permeabilized cells are for measuring intracellular target (e.g., protein) expression.

Abstract: A method and apparatus with battery short circuit detection are included. In one general aspect, a processor-implemented method includes, based on battery data measured by a battery and a battery model of the battery, determining a detection parameter value used for detecting a short circuit of the battery and a variation factor value correlated with the detection parameter, using the variation factor to extract a reference value corresponding to the detection parameter value from a reference data set, and determining whether a short circuit of the battery has occurred based on a result of comparing the detection parameter value with the reference value.

Abstract: Disclosed herein include systems, methods, kits, and compositions for labeling nuclear target-associated DNA in a cell. Some embodiments provide digestion compositions comprising a DNA digestion enzyme and a binding reagent capable of specifically binding to the nuclear target. Some embodiments provide conjugates comprising a transposome and a binding reagent capable of specifically binding to a nuclear target. The transposome can comprise a transposase (e.g., Tn5 transposase), a first adaptor having a first 5? overhang, and a second adaptor having a second 5? overhang. The methods can comprise contacting a permeabilized cell comprising a nuclear target associated with dsDNA, such as genomic DNA (gDNA), with the compositions provided herein to generate a plurality of nuclear target-associated dsDNA fragments (e.g., nuclear target-associated gDNA fragments) each comprising the one or two single-stranded overhangs.