Abstract: Disclosed are compositions and/or methods of use of the compositions for patients with neuronal diseases such as AD, Parkinson's, Huntington's, multiple sclerosis, and ALS. In certain embodiments flavonoids alone, or in a pharmaceutical preparation, are administered through the nasal olfactory route. In certain embodiments the flavonoid is apigenin and the neural disease is Alzheimer's. In some embodiments a porosome complex is administered for reconstitution into a neural cell. In certain embodiments, a co-administered blood-brain barrier traversing peptide is configured as a mimic of a domain of ATP1A3 and/or Tubulin.

Abstract: Disclosed are compositions and/or methods of use of the compositions for patients with neuronal diseases such as AD, Parkinson's, Huntington's, multiple sclerosis, and ALS. In certain embodiments flavonoids alone, or in a pharmaceutical preparation, are administered through the nasal olfactory route. In certain embodiments the flavonoid is apigenin and the neural disease is Alzheimer's. Targeted dosages may affect mitochondrial function in brain neural cells thus ameliorating a neural disease. In some embodiments a porosome complex is administered for reconstitution into a neural cell. In certain embodiments, one or more macrocyclic or linear peptides are administered.

Abstract: Disclosed are multi-peptide compositions and/or methods of use of the multi-peptide compositions for subjects suffering from or at risk for a neural disease. Pharmaceutically acceptable embodiments administered subjects may treat or prevent the neural disease. In certain embodiments, a flavonoid compound is administered in conjunction with a peptide. In still other embodiments, a porosome complex is administered with the peptide and/or with the flavonoid compound.

Abstract: The present disclosure relates to compositions for the restoration of porosome function, comprising isolated porosome complexes that include a functional CFTR protein and a pharmaceutically acceptable excipient. These compositions are specifically formulated for inhaled or nasal administration, enabling delivery of the functional porosome complexes directly to the airway epithelium. By restoring the presence of functional CFTR within the porosome complex at the plasma membrane, the disclosed compositions address the underlying secretory defect in cystic fibrosis and provide a novel therapeutic approach for patients affected by this disease.

Abstract: The porosome is the main secretory structure of the eukaryotic cell. Presented herein are compositions and methods for the control and regulation of the porosome structure. Including a method of porosome-associated-protein and interacting small molecule identification; usage of small molecules targeted to one or more porosome proteins; compositions and usages of nanobodies coupled with small molecules; the reconstitution of porosomes; and the creation and usage of artificial porosome structures.

Abstract: This disclosure provides a porosome composition for treating cystic fibrosis comprising an isolated porosome comprising a WT-CFTR protein and a pharmaceutically acceptable excipient. The porosomes can be porosomes isolated from human epithelial cells and may also contain additional CFTR associated proteins, such as SNAP-23 or IQGAP1. The composition can be a liquid or solid (fine granule) composition suitable for oral or nasal inhalation. Nebulizer compositions are particularly provided. The disclosure also provides methods of treating cystic fibrosis comprising administering a composition of the disclosure to a patient in need of such treatment.

Abstract: The porosome is the main secretory structure of the eukaryotic cell. Presented herein are compositions and methods for the control and regulation of the porosome structure. Including a method of porosome-associated-protein and interacting small molecule identification; usage of small molecules targeted to one or more porosome proteins; compositions and usages of nanobodies coupled with small molecules; the reconstitution of porosomes; and the creation and usage of artificial porosome structures.

Abstract: A gate driving device may include a plurality of inverter arms, respective inverter arms including a high-side switch and a low-side switch, a gate driving unit including a multi-channel gate driver that outputs control signals to control switching of the plurality of inverter arms, and a plurality of gate drivers, respective gate drivers receiving one of the control signals to output it to a corresponding high-side switch, and a balancing unit maintaining balance of voltage between the multi-channel gate driver and the plurality of gate drivers.

Abstract: There are provided an all-in-one power supply apparatus capable of concurrently supplying battery charging power and main power, in particular, main power for driving an electric vehicle, and a power supply apparatus for an electric vehicle. The power supply apparatus and the power supply apparatus for an electric vehicle respectively including: a charging unit; a main power supplying unit; and an auxiliary power supplying unit.

Abstract: There is provided a gate driving device, including: an inverter arm including a high-side switch and a low-side switch; a gate driving unit receiving an instruction signal to provide switching control to the inverter arm, outputting a control signal to control switching of the inverter arm, and including a plurality of gate drivers; and a balancing unit causing voltage applied to the plurality of gate drivers to be divided to be supplied to respective gate drivers among the plurality of gate drivers, according to the switching of the inverter arm based on the control signal.

Abstract: A gate driving device may include a plurality of inverter arms, respective inverter arms including a high-side switch and a low-side switch, a gate driving unit including a multi-channel gate driver that outputs control signals to control switching of the plurality of inverter arms, and a plurality of gate drivers, respective gate drivers receiving one of the control signals to output it to a corresponding high-side switch, and a balancing unit maintaining balance of voltage between the multi-channel gate driver and the plurality of gate drivers.

Abstract: A gate driving device may include an inverter arm including a high-side switch and a low-side switch, a gate driving unit including a first gate driver that receives an instruction signal to command switching controlling of the inverter arm to output a switching control signal for the high-side switch and the low-side switch, and a second gate driver that receives the switching control signal for the high-side switch to be output to the high-side switch, and a balancing unit maintaining balance in voltage between the first gate driver and the second gate driver, according to the switching of the inverter arm based on the switching control signal for the high-side switch.

Abstract: There is provided a gate driving device, including: an inverter arm including a high-side switch and a low-side switch; a gate driving unit receiving an instruction signal to provide switching control to the inverter arm, outputting a control signal to control switching of the inverter arm, and including a plurality of gate drivers; and a balancing unit causing voltage applied to the plurality of gate drivers to be divided to be supplied to respective gate drivers among the plurality of gate drivers, according to the switching of the inverter arm based on the control signal.

Abstract: There are provided a power supplying apparatus controlling voltage of a power factor correcting circuit according to a power state and a power charging apparatus controlling voltage of a power factor correcting circuit according to a charging state of a battery. The power supplying apparatus includes: a power factor correcting circuit switching input power to correct a power factor thereof and adjusting a voltage level of the power of which the power factor has been corrected according to a state of power transferred to a load; and a resonant DC to DC converting circuit having a resonance frequency varied according to a voltage level of DC power from the power factor correcting circuit and converting the DC power from the power factor correcting circuit into supply power having a preset level according to the resonance frequency.

Abstract: There are provided an all-in-one power supply apparatus capable of concurrently supplying battery charging power and main power, in particular, main power for driving an electric vehicle, and a power supply apparatus for an electric vehicle. The power supply apparatus and the power supply apparatus for an electric vehicle respectively including: a charging unit; a main power supplying unit; and an auxiliary power supplying unit.

Abstract: There are provided a power supplying apparatus controlling voltage of a power factor correcting circuit according to a power state and a power charging apparatus controlling voltage of a power factor correcting circuit according to a charging state of a battery. The power supplying apparatus includes: a power factor correcting circuit switching input power to correct a power factor thereof and adjusting a voltage level of the power of which the power factor has been corrected according to a state of power transferred to a load; and a resonant DC to DC converting circuit having a resonance frequency varied according to a voltage level of DC power from the power factor correcting circuit and converting the DC power from the power factor correcting circuit into supply power having a preset level according to the resonance frequency.

Abstract: Disclosed herein is a switching power supply including: N sub switching power supplying unit each converting a direct current (DC) power supplied from a power source into an alternate current (AC) power, boosting or bucking the AC power using a resonant circuit and a contactless transformer, converting the boosted or bucked AC power into a DC power, and outputting the converted DC power; and a balance circuit connecting between the resonant circuits of the N sub switching power supplying units to thereby allow currents to be balanced between the resonant circuits.