Patents by Inventor Woodring E. Wright
Woodring E. Wright has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190029301Abstract: A method for treating a subject with multiple myeloma includes a step of identifying a patient having multiple myeloma. A fasting mimicking and enhancing diet is administered to the subject for a predetermined time period of at least 8 days. A diet package for implementing the method is also provided.Type: ApplicationFiled: January 12, 2017Publication date: January 31, 2019Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Valter D. LONGO, Woodring E. WRIGHT
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Publication number: 20030190638Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: ApplicationFiled: August 29, 2002Publication date: October 9, 2003Applicant: Board of Regents, The University of Texas SystemInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 6551774Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: August 20, 1999Date of Patent: April 22, 2003Assignees: Board of Regents, The University of Texas System, The Regents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 6391554Abstract: Methods and kits are provided for diagnosis of specific cancerous conditions. The invention features a method for diagnosis of a condition in a patient associated with an elevated level of telomerase activity within a cell. The method involves determining the presence or amount of telomerase within the cells in the patient, e.g. by the use of the polymerase chain reaction. In one embodiment of the invention, the condition associated with elevated telomerase activity is chosen from prostate cancer, breast cancer, colon cancer, renal cancer, ovarian/cervical cancer, lung cancer, and leukemia. The invention allows cancer to be detected even in tissues and cells which are not positive by pathology.Type: GrantFiled: November 23, 1999Date of Patent: May 21, 2002Assignees: Geron Corporation and Board of Regents, The University of Texas SystemsInventors: Michael D. West, Jerry W. Shay, Woodring E. Wright, Nam Woo Kim, Calvin B. Harley, Scott L. Weinrich
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Patent number: 6294650Abstract: The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.Type: GrantFiled: July 8, 1999Date of Patent: September 25, 2001Assignee: The Board of Regents, University of Texas SystemInventors: Jerry W. Shay, Woodring E. Wright, Mieczyslaw A. Piatyszek, David R. Corey, James C. Norton
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Patent number: 6210915Abstract: A method of extracting telomerase from a cell sample having telomerase is provided which includes the step of contacting a cell sample with a buffer having (i) a non-ionic detergent at a concentration of not more than 5% (v/v) and (ii) an ionic detergent at a concentration of not more than 1 mM, to form a cell lysate. The method provides efficient extraction of telomerase that can be assayed for diagnostic and prognostic purposes.Type: GrantFiled: December 23, 1998Date of Patent: April 3, 2001Assignee: University of Texas SystemsInventors: Jerry W. Shay, Woodring E. Wright, James C. Norton, Jr.
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Patent number: 6046307Abstract: The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.Type: GrantFiled: April 9, 1997Date of Patent: April 4, 2000Assignee: The University of Texas SystemInventors: Jerry W. Shay, Woodring E. Wright, Mieczyslaw A. Piatyszek, David R. Corey, James C. Norton
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Patent number: 6015710Abstract: The invention relates to peptide nucleic acids that modulate telomerase activity in mammalian cells.Type: GrantFiled: April 9, 1996Date of Patent: January 18, 2000Assignee: The University of Texas SystemInventors: Jerry W. Shay, Woodring E. Wright, Mieczyslaw A. Piatyszek, David R. Corey, James C. Norton
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Patent number: 6007989Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: March 14, 1997Date of Patent: December 28, 1999Assignees: Board of Regents, The University of Texas System, The Regents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 5989807Abstract: Methods and kits are provided for diagnosis of specific cancerous conditions. The invention features a method for diagnosis of a condition in a patient associated with an elevated level of telomerase activity within a cell. The method involves determining the presence or amount of telomerase within the cells in the patient, e.g. by the use of the polymerase chain reaction. In one embodiment of the invention, the condition associated with elevated telomerase activity is chosen from prostate cancer, breast cancer, colon cancer, renal cancer, ovarian/cervical cancer, lung cancer, and leukemia. The invention allows cancer to be detected even in tissues and cells which are not positive by pathology.Type: GrantFiled: June 7, 1994Date of Patent: November 23, 1999Assignees: Geron Corporation & Board of Regents, The University of Texas SystemInventors: Michael D. West, Jerry Shay, Woodring E. Wright, Nam Woo Kim, Calvin B. Harley, Scott L. Weinrich
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Patent number: 5830644Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: November 12, 1993Date of Patent: November 3, 1998Assignees: Geron Corporation, Board of Regents, The University of Texas SystemInventors: Michael D. West, Jerry Shay, Woodring E. Wright
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Patent number: 5693474Abstract: A method for predicting tumor progression and prognosing cancer comprises: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the activity with a standard level of telomerase activity; and (d) correlating a high telomerase activity with an indication of unfavorable prognosis and a low telomerase activity with a favorable prognosis.Type: GrantFiled: June 7, 1995Date of Patent: December 2, 1997Assignee: Board of Regents, University of Texas SystemInventors: Jerry Shay, Michael David West, Woodring E. Wright
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Patent number: 5686306Abstract: Method and compositions for increasing telomere length in normal cells can be used to increase the proliferative capacity of cells and to delay the onset of cellular senescence.Type: GrantFiled: November 10, 1994Date of Patent: November 11, 1997Assignee: Board of Regents, The University of Texas SystemInventors: Michael D. West, Jerry Shay, Woodring E. Wright
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Patent number: 5648215Abstract: The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose the course of disease progression in a patient.Type: GrantFiled: September 28, 1994Date of Patent: July 15, 1997Assignee: Board of Regents, The University of Texas SystemInventors: Michael D. West, Jerry Shay, Woodring E. Wright
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Patent number: 5645986Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: November 12, 1993Date of Patent: July 8, 1997Assignees: Board of Reagents, The University of Texas System, The Reagents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Homayoun Vaziri
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Patent number: 5639613Abstract: A method for predicting tumor progression and prognosing cancer comprises: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the activity with a standard level of telomerase activity; and (d) correlating a high telomerase activity with an indication of unfavorable prognosis and a low telomerase activity with a favorable prognosis.Type: GrantFiled: April 18, 1995Date of Patent: June 17, 1997Assignee: Board of Regents, University of Texas SystemInventors: Jerry Shay, Michael David West, Woodring E. Wright
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Patent number: 4659663Abstract: A method for isolating the fusion product of two cell populations is disclosed. The method involves the introduction of a specific antitoxin into cells of one population while introducing a second specific antitoxin into cells of the second population. After fusing cells of the first population with those of the second population, the fusion product may be selectively isolated on a medium containing an appropriate amount of both first and second toxins. For some applications, it may be appropriate to introduce an antitoxin into only one of the cell populations and isolate the fusion product on a media containing only one toxin.Type: GrantFiled: October 1, 1984Date of Patent: April 21, 1987Assignee: Board of Regents, University of Texas SystemInventor: Woodring E. Wright