Patents by Inventor Woodring Wright

Woodring Wright has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds having anti-adhesive effects on cancer cells
    Patent number: 9732114
    Abstract: Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3??P5? thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: August 15, 2017
    Assignees: GERON CORPORATION, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sergei M. Gryaznov, Jerry W. Shay, Woodring Wright
  • Compounds Having Anti-Adhesive Effects on Cancer Cells
    Publication number: 20140329890
    Abstract: Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3??P5? thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells.
    Type: Application
    Filed: July 21, 2014
    Publication date: November 6, 2014
    Applicants: GERON CORPORATION, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sergei M. Gryaznov, Jerry W. Shay, Woodring Wright
  • Compounds having anti-adhesive effects on cancer cells
    Patent number: 8785409
    Abstract: Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3??P5? thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: July 22, 2014
    Assignees: Geron Corporation, Board of Regents of the University of Texas System
    Inventors: Sergei M. Gryaznov, Jerry W. Shay, Woodring Wright
  • Compounds Having Anti-Adhesive Effects on Cancer Cells
    Publication number: 20130296405
    Abstract: Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3?->P5? thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 7, 2013
    Inventors: Sergei Gryaznov, Jerry Shay, Woodring Wright
  • COMPOUNDS HAVING ANTI-ADHESIVE EFFECTS ON CANCER CELLS
    Publication number: 20100113571
    Abstract: Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3?->P5? thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 6, 2010
    Inventors: Sergei M. Gryaznov, Jerry W. Shay, Woodring Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Publication number: 20070010476
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
    Type: Application
    Filed: September 14, 2006
    Publication date: January 11, 2007
    Inventors: Michael West, Jerry Shay, Woodring Wright, Elizabeth Blackburn
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Publication number: 20060172960
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
    Type: Application
    Filed: July 12, 2005
    Publication date: August 3, 2006
    Inventors: Michael West, Jerry Shay, Woodring Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Publication number: 20040198659
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
    Type: Application
    Filed: October 22, 2003
    Publication date: October 7, 2004
    Applicants: Regents of the University of California, Board of Regents of the University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring Wright, Elizabeth H. Blackhurn
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Publication number: 20030175766
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Application
    Filed: December 18, 2002
    Publication date: September 18, 2003
    Applicant: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • THERAPY AND DIAGNOSIS OF CONDITIONS RELATED TO TELOMERE LENGTH AND/OR TELOMERASE ACTIVITY
    Publication number: 20020127634
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
    Type: Application
    Filed: June 5, 1995
    Publication date: September 12, 2002
    Inventors: MICHAEL D. WEST, JERRY SHAY, WOODRING WRIGHT, ELIZABETH H. BLACKBURN
  • Screening methods to identify inhibitors of telomerase activity
    Patent number: 6368789
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 9, 2002
    Inventors: Michael D. West, Jerry Shay, Woodring Wright, Elizabeth H. Blackburn
  • Use of oligonucleotide telomerase inhibitors to reduce telomere length
    Patent number: 6194206
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: December 24, 1997
    Date of Patent: February 27, 2001
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Methods for diagnosis of conditions associated with elevated levels of telomerase activity
    Patent number: 5840495
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Patent number: 5707795
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 13, 1998
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Telomerase activity assays for diagnosing pathogenic infections
    Patent number: 5695932
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
    Type: Grant
    Filed: May 13, 1993
    Date of Patent: December 9, 1997
    Assignees: University of Texas System, The Regents of the University of California
    Inventors: Michael D. West, Jerry Shay, Woodring Wright, Elizabeth H. Blackburn, Michael J. McEachern
  • Methods for screening for agents which modulate telomere length
    Patent number: 5686245
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 11, 1997
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Patent number: 5489508
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: February 6, 1996
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright