Patents by Inventor Wouter Cornelis Puijk
Wouter Cornelis Puijk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220135693Abstract: The present invention provides novel humanized anti-human CCR7 antibodies and compositions comprising such antibodies. The antibodies and compositions are useful in the treatment of a cancer of which the tumour cells express a CCR7 receptor, in the treatment of inflammatory conditions, conditions or complications arising from tissue or organ transplantations, and conditions or complications arising from or associated with fibrosis. The invention further provides nucleic acid molecules encoding the anti-CCR7 antibodies, cells expressing the anti-CCR7 antibodies and methods for producing the anti-CCR7 antibodies.Type: ApplicationFiled: January 18, 2022Publication date: May 5, 2022Applicant: PepMab B.V.Inventors: Jaap Willem Back, Ronald Boshuizen, Wouter Cornelis Puijk, Johan Turkstra, Klaus Heinrich Schwamborn
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Patent number: 11254749Abstract: The present invention provides novel humanized anti-human C—C chemokine receptor type 7 (CCR7) antibodies and compositions comprising such antibodies. The antibodies and compositions are useful in the treatment of a cancer of which the tumour cells express a CCR7 receptor, in the treatment of inflammatory conditions, conditions or complications arising from tissue or organ transplantations, and conditions or complications arising from or associated with fibrosis. The invention further provides nucleic acid molecules encoding the anti-CCR7 antibodies, cells expressing the anti-CCR7 antibodies and methods for producing the anti-CCR7 antibodies.Type: GrantFiled: March 10, 2020Date of Patent: February 22, 2022Assignee: PepMab B.V.Inventors: Jaap Willem Back, Ronald Boshuizen, Wouter Cornelis Puijk, Johan Turkstra, Klaus Heinrich Schwamborn
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Publication number: 20200362043Abstract: The present invention provides novel humanized anti-human CCR7 antibodies and compositions comprising such antibodies. The antibodies and compositions are useful in the treatment of a cancer of which the tumour cells express a CCR7 receptor, in the treatment of inflammatory conditions, conditions or complications arising from tissue or organ transplantations, and conditions or complications arising from or associated with fibrosis. The invention further provides nucleic acid molecules encoding the anti-CCR7 antibodies, cells expressing the anti-CCR7 antibodies and methods for producing the anti-CCR7 antibodies.Type: ApplicationFiled: March 10, 2020Publication date: November 19, 2020Applicant: PepMab B.V.Inventors: Jaap Willem Back, Ronald Boshuizen, Wouter Cornelis Puijk, Johan Turkstra, Klaus Heinrich Schwamborn
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Patent number: 10640565Abstract: The present invention provides novel humanized anti-human C-C chemokine receptor type 7 (CCR7) antibodies and compositions comprising such antibodies. The antibodies and compositions are useful in the treatment of a cancer of which the tumour cells express a CCR7 receptor, in the treatment of inflammatory conditions, conditions or complications arising from tissue or organ transplantations, and conditions or complications arising from or associated with fibrosis. The invention further provides nucleic acid molecules encoding the anti-CCR7 antibodies, cells expressing the anti-CCR7 antibodies and methods for producing the anti-CCR7 antibodies.Type: GrantFiled: August 10, 2016Date of Patent: May 5, 2020Assignee: PepMab B.V.Inventors: Jaap Willem Back, Ronald Boshuizen, Wouter Cornelis Puijk, Johan Turkstra, Klaus Heinrich Schwamborn
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Publication number: 20180237529Abstract: The present invention provides novel humanized anti-human CCR7 antibodies and compositions comprising such antibodies. The antibodies and compositions are useful in the treatment of a cancer of which the tumour cells express a CCR7 receptor, in the treatment of inflammatory conditions, conditions or complications arising from tissue or organ transplantations, and conditions or complications arising from or associated with fibrosis. The invention further provides nucleic acid molecules encoding the anti-CCR7 antibodies, cells expressing the anti-CCR7 antibodies and methods for producing the anti-CCR7 antibodies.Type: ApplicationFiled: August 10, 2016Publication date: August 23, 2018Applicant: PepMab B.V.Inventors: Jaap Willem Back, Ronald Boshuizen, Wouter Cornelis Puijk, Johan Turkstra
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Patent number: 8748105Abstract: The invention relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule capable of reacting with the at least first and second reactive group; contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the at least one molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage, preferably wherein the coupling reaction is performed in solution, more preferably in an aqueous solution. Furthermore, a method is provided for selecting a candidate drug compound comprising providing a library of compounds according to the invention and determining the binding of a target molecule to the compounds.Type: GrantFiled: August 26, 2005Date of Patent: June 10, 2014Assignee: Pepscan Systems B.V.Inventors: Peter Timmerman, Joris Beld, Robbert Hans Meloen, Wouter Cornelis Puijk
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Patent number: 8742070Abstract: The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds.Type: GrantFiled: April 10, 2012Date of Patent: June 3, 2014Assignee: Pepscan Systems B.V.Inventors: Peter Timmerman, Joris Beld, Robbert Hans Meloen, Wouter Cornelis Puijk
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Publication number: 20130158232Abstract: The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds.Type: ApplicationFiled: April 10, 2012Publication date: June 20, 2013Inventors: Peter TIMMERMAN, Joris Beld, Robbert Hans Meloen, Wouter Cornelis Puijk
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Publication number: 20120190564Abstract: The disclosure relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular, in relation to protein-protein, protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. Provided is a synthetic molecular library allowing testing for, identification, characterization, or detection of a discontinuous binding site able to interact with a binding molecule, the library having been provided with a plurality of test entities, each test entity comprising at least one first segment spotted next to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.Type: ApplicationFiled: May 5, 2011Publication date: July 26, 2012Inventors: Jelle Wouter Slootstra, Wouter Cornelis Puijk, Robert Hans Meloen, Evert van Dijk, Pieter van Dijken
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Patent number: 7972993Abstract: The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular, in relation to protein-protein, protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. The invention provides a synthetic molecular library allowing testing for, identification, characterization or detection of a discontinuous binding site capable of interacting with a binding molecule, the library having been provided with a plurality of test entities, each test entity comprising at least one first segment spotted next to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.Type: GrantFiled: April 10, 2003Date of Patent: July 5, 2011Assignee: Pepscan Systems B.V.Inventors: Jelle Wouter Slootstra, Wouter Cornelis Puijk, Robbert Hans Meloen, Pieter van Dijken, Evert van Dijk
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Patent number: 7863239Abstract: The invention provides means and methods for producing compounds suitable for testing for the presence and/or identification of an immunogenic compound and/or a binding compound of interest. Immunogenic compounds and compositions are also herewith provided, as well as peptidomimetics of members of the cystine-knot family.Type: GrantFiled: January 24, 2006Date of Patent: January 4, 2011Assignee: Pepscan Systems B.V.Inventors: Peter Timmerman, Wouter Cornelis Puijk, Jelle Wouter Slootstra, Evert van Dijk, Robbert Hans Meloen
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Publication number: 20100322945Abstract: The invention provides means and methods for inducing and/or enhancing immunogenic reproducibility and/or immunogenicity of a compound, comprising at least in part restricting the conformation of said compound. The conformation is preferably restricted by the formation of at least one internal bond within said compound. Protein mimics comprising an amino acid sequence bound to a scaffold and/or a carrier, wherein said amino acid sequence comprises at least one internal SS-bridge, are also herewith provided.Type: ApplicationFiled: July 26, 2007Publication date: December 23, 2010Inventors: Peter Timmerman, Wouter Cornelis Puijk, Robbert Hans Meloen
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Publication number: 20080313749Abstract: The invention provides means and methods for producing compounds suitable for testing for the presence and/or identification of an immunogenic compound and/or a binding compound of interest. Immunogenic compounds and compositions are also herewith provided, as well as peptidomimetics of members of the cystine-knot family.Type: ApplicationFiled: January 24, 2006Publication date: December 18, 2008Inventors: Peter Timmerman, Wouter Cornelis Puijk, Jelle Wouter Slootstra, Evert Van Dijk, Robert Hans Meloen
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Publication number: 20080139407Abstract: The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular in relation to protein-protein protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. The invention provides a synthetic molecular library allowing testing for, identification, characterisation or detection of a discontinuous binding site capable of interacting with a binding molecule, the library having been provided with a plurality of molecules, each molecule of the molecules comprising at least one first segment linked to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.Type: ApplicationFiled: April 23, 2007Publication date: June 12, 2008Applicant: PEPSCAN SYSTEMS B. V.Inventors: Jelle Wouter Slootstra, Evert Van Dijk, Wouter Cornelis Puijk
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Publication number: 20040114780Abstract: The invention relates to the detection of biomolecules or analogs thereof in micro-arrays and the supports used for the micro-arrays. Methods for determining or testing binding of a first member molecule within an array or library of tentative first member binding molecules for binding with a second member binding molecule are disclosed. A support for a micro-array suitable for determining binding of a first member molecule within a library of spots of tentative first member binding molecules with a second member binding molecule is disclosed. The support includes a support surface wherein surface patches are interspersed within surface areas that are materially distinct from the patches.Type: ApplicationFiled: August 14, 2003Publication date: June 17, 2004Inventors: Wouter Cornelis Puijk, Evert van Dijk, Jelle Wouter Slootstra
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Publication number: 20040110224Abstract: The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular in relation to protein-protein protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. The invention provides a synthetic molecular library allowing testing for, identification, characterisation or detection of a discontinuous binding site capable of inter-acting with a binding molecule, said library having been provided with a plurality of molecules, each molecule of said molecules comprising at least one first segment linked to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.Type: ApplicationFiled: November 25, 2002Publication date: June 10, 2004Inventors: Jelle Wouter Slootstra, Evert van Dijk, Wouter Cornelis Puijk
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Publication number: 20030228605Abstract: The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular, in relation to protein-protein, protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. The invention provides a synthetic molecular library allowing testing for, identification, characterization or detection of a discontinuous binding site capable of interacting with a binding molecule, the library having been provided with a plurality of test entities, each test entity comprising at least one first segment spotted next to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.Type: ApplicationFiled: April 10, 2003Publication date: December 11, 2003Inventors: Jelle Wouter Slootstra, Wouter Cornelis Puijk, Robert Hans Meloen, Evert van Dijk, Pieter van Dijken
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Publication number: 20030226169Abstract: The present invention provides DNA sequences encoding antifungal peptides which comprise at least six amino acid residues identical to a run of amino acid residues found between position 21 and position 51 of the Rs-AFP2 antifungal protein sequence (SEQ ID NO: 35) or a substantially homologous protein.Type: ApplicationFiled: March 13, 2003Publication date: December 4, 2003Inventors: Aart Van Amerongen, Franky Fant, Frans Alois Melania Borremans, Genoveva Wivina De Samblanx, Lolke Sijtsma, Robbert Hans Meloen, Wouter Cornelis Puijk, Wilhelmus Martinus Maria Schaaper, Willem Frans Broekaert, Wilhelmus Martinus Jozef Van Gelder, Sarah Bronwen Rees
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Patent number: 6605698Abstract: Antifungal peptides which comprise at least six amino acid residues identical to a run of amino acid residues found between position 21 and position 51 of the Rs-AFP2 antifungal protein sequence or of substantially homologous protein sequences. The peptides are useful for combating fungal diseases in agricultural, pharmaceutical or preservative applications.Type: GrantFiled: August 7, 1998Date of Patent: August 12, 2003Assignee: Syngenta LimitedInventors: Aart Van Amerongen, Franky Fant, Frans Alois Borremans, Genoveva Wivina De Samblanx, Lolke Sijtsma, Robbert Hans Meloen, Wouter Cornelis Puijk, Wilhelmus Martinus Maria Schaaper, Willem Frans Broekaert, Wilhelmus Martinus Josef van Gelder, Sarah Bronwen Rees
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Publication number: 20010021513Abstract: A test device comprises a plate containing a multiplicity of wells and an associated metering device suitable for simultaneously introducing equal volumes of reagent into different wells of the test device. The test device comprises wells which have a volume within the range of 0.1-20 &mgr;l. The ratio between the depth of the wells and the diameter is preferably less than 1:1. The test device according to the invention can be used for carrying out the bio- or immuno-chemical test such as a pepscan or ELISA.Type: ApplicationFiled: January 5, 2001Publication date: September 13, 2001Inventors: Wouter Cornelis Puijk, Gerard Johannes Ligtvoet, Robbert Hans Meloen