Abstract: Many people need vascular access for procedures such as hemodialysis. It is desirable that this access remain open or patent for the entire duration of the course of treatments. A drug delivery device and methods of using the device are introduced that delivery drug to venous anastomosis of a synthetic vascular access shunt. In some embodiments this device serves as the shunt connecting the target artery and vein to create the vascular access shunt.

Abstract: A closure device for closing an opening in tissue is provided. The closure device includes an elongate member through which needles may be deployed. The closure device also includes a closure element having a foot portion and a needle guide portion. The foot portion and the needle guide portion are each movable between a delivery configuration and a deployed configuration. The foot portion includes cuffs removably mounted thereon and having sutures connected therebetween. The needle guide portion includes needle guide apertures that guide the needles to the cuffs. The needles securely engage the cuffs and draw the cuffs and suture through the lumen wall so that the opening in the lumen wall can be closed with the sutures.

Abstract: A suture applying device includes a shaft which carries a pair of needles near its distal end. The needles are joined by a length of suture, and the shaft is used to both introduce the needles into a lumen of a body structure and to draw the needles back through tissue on either side of the puncture site. After the needles have passed through the tissue, they are captured by a needle receiver and drawn outward through the tract, leaving a loop of suture behind to close the puncture site near the body lumen. The suture can then be tied or otherwise secured to close the puncture site.

Abstract: Methods and apparatuses for closure of vascular punctures or other openings in bodily tissues. The apparatuses and methods described herein are configured for everting a portion of tissue around a puncture site for wound closure on the external surface of the wound. For example, the tissue eversion apparatus may be configured for drawing up a portion of a vessel surrounding a venous or arterial puncture and orienting the inner surface of the vessel at least partially outward so that a closure element may be placed around the inverted region on the exterior surface of the vessel. In some embodiments, the devices are bioabsorbable.

Abstract: A closure device is provided for clamping sutures when closing an opening in tissue. The closure device includes an inner part and an outer part. Sutures drawn through the inner part and the outer part are clamped and held in place when the inner part is pressed together with the outer part.

Abstract: A closure device and system for closing openings in tissue. After placing sutures in the tissue, the sutures are clamped by the closure device to hold the sutures in place and close the opening in the tissue.

Abstract: Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.

Abstract: A device for engaging tissue may include a generally annular-shaped body defining a plane and disposed about a central axis extending substantially normal to the plane. The body may be movable from a substantially planar configuration lying generally in the plane towards a transverse configuration extending out of the plane. The body may include a plurality of looped elements including alternating inner and outer curved regions. The inner curved regions may define an inner periphery of the body and the outer curved regions may define an outer periphery of the body in the planar configuration. A plurality of tines may extend from the outer curved regions. The tines may be oriented generally towards the central axis in the planar configuration and generally parallel to the central axis in the transverse configuration. The tines may extend beyond the central axis without passing through the central axis so as to collectively form a central lumen about the central axis in the planar configuration.

Abstract: Hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, wrappings, wound dressings, wound coverings, wound dressings, incision dressings, sealers, sheets, rolls, combinations thereof, and the like.

Abstract: Implantable hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of implantable medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of internal bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, dressings, wound plugs, incision plugs, arteriotomy plugs, tissue fillers, sealers, sheets, rolls, combinations thereof, and the like.

Abstract: Compositions and methods of using the compositions to achieve a therapeutic effect are provided.

Abstract: A method and system of coating an implantable device, such as a stent, are provided.

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polymer having in a dry state a glass transition temperature within a range of between about 20° C. and about 55° C.

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

Abstract: A process for coating an implantable device is disclosed. In this process, at least one implantable device is tumbled. As the implantable device is being tumbled, a coating substance is introduced to coat the implantable device with the coating substance.

Abstract: The present invention relates to providing a porous, hydrophobic polymer with a hemocompatible substance and to the materials produced thereby. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrochlorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.

Abstract: Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.

Abstract: Apparatuses and methods for administering a hemostatic agent to the tissue surrounding an opening in a body lumen are disclosed. The apparatus can include a tissue-contacting region and an optional body lumen-penetrating region. At least one hemostatic agent is included as a component of a coating over and/or a mixture with the material of at least a portion of the tissue-contacting region.

Abstract: The present disclosure includes vessel closure devices, systems, and methods. A closure device configured to close an opening in a body lumen may include an elongate member having a distal end and a proximal end. An anchor member may be disposed on the elongate member proximate the distal end of the elongate member. A cap member may also be disposed on the elongate member a distance from the distal end of the elongate member. The anchor member and the cap member cooperate to close the opening in the body lumen.