Abstract: Biocompatible terpolymers are manufactured to include a zwitterionic monomer, an alkoxy acrylate monomer, and a hydrophobic monomer.

Abstract: Biocompatible terpolymers are manufactured to include a zwitterionic monomer, an alkoxy acrylate monomer, and a hydrophobic monomer.

Abstract: The disclosed subject matter describes systems and methods of delivering a therapeutic agent, such as a sclerosing agent, to the walls of a blood vessel to perform sclerotherapy. In an exemplary embodiment a catheter includes a guidewire catheter having at least one guidewire lumen extending therethrough and a slidable concentric tube disposed over the guidewire catheter. At least one bellow is coupled to the concentric tube and configured for conversion between an unexpanded and expanded configuration wherein movement of the concentric tube in a first direction causes the at least one bellow to expand and movement of the concentric tube in a second direction causes the at least one bellow to contract. Additionally, the concentric tube contains at least one port for delivery of a therapeutic agent, e.g. a sclerosing agent. The at least one bellow expands and contracts via mechanical forces.

Abstract: Biocompatible terpolymers are manufactured to include a zwitterionic monomer, an alkoxy acrylate monomer, and a hydrophobic monomer.

Abstract: Biocompatible terpolymers are manufactured to include a zwitterionic monomer, an alkoxy acrylate monomer, and a hydrophobic monomer.

Abstract: Biocompatible terpolymers are manufactured to include a zwitterionic monomer, an alkoxy acrylate monomer, and a hydrophobic monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or a 2-methoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-methoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.

Abstract: The present invention is directed to implantable devices (e.g., drug-delivery stents) containing nuclear receptor ligands. The nuclear receptor ligands may be, inter alia, PPAR ligands or retinoids. The invention also provides for a method of treating or preventing vascular disorders (e.g., restenosis) and related disorders using the nuclear receptor ligand-containing devices.

Abstract: An implantable drug delivery pump includes a reservoir, a dispensing chamber adjacent to the reservoir, a dispensing passage provided along an interior surface of the dispensing chamber, and an actuator for applying a moving compressive force onto the dispensing passage. The pump is subcutaneously implantable in a patient, and a drug is injected into the reservoir through a septum provided on a housing for the reservoir. As the compressive force applied by the actuator moves along the dispensing passage, the drug preparation is simultaneously pushed out of the dispensing passage into a catheter for delivery to the desired site, and additional drug preparation is drawn into the dispensing passage from the reservoir. The actuator includes a rotating arm driven by an motor at a controllable rate.