Patents by Inventor Wouter-Jan Rappel
Wouter-Jan Rappel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11147462Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: GrantFiled: September 26, 2018Date of Patent: October 19, 2021Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans AffairsInventors: Sanjiv M. Narayan, Wouter-Jan Rappel
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Patent number: 10918303Abstract: A method and system for determining a source of a cardiac rhythm disorder includes collecting cardiac signals at a plurality of locations during a cardiac arrhythmia and identifying activation times within the cardiac signals. After computing the time-dependent phase of each region of tissue, a level of phase synchrony is determined between each pair of locations to assign a synchronization number for each pair of locations. Using the synchronization number, a spatial synchrony map is generated to identify one or more asynchronous tissue regions surrounded by regions of synchrony in the patient's heart.Type: GrantFiled: March 24, 2017Date of Patent: February 16, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Wouter-Jan Rappel, David Vidmar
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Patent number: 10835139Abstract: Methods and systems are provided for determination and mapping of vector fields which characterize wavefront motion through space and time. The inventive methods and systems utilize data from spatially-distributed locations and maps wavefront vector flow fields in an entirely automated manner. These maps can be used to characterize the activation as planar, centrifugal, or rotational. Further, the strength of rotation or divergence is determined from these fields and can be used to select spatial points of significantly increased rotational or focal activity. As applied to electrophysiological data recorded during heart rhythm disorders in patients, the inventive method provides a means of visual interpretation of complex activation maps. The information related to the strength and location of rotation and centrifugal activity during episodes of arrhythmia can guide therapies designed to treat such disorders.Type: GrantFiled: March 24, 2017Date of Patent: November 17, 2020Assignee: The Regents of the University of CaliforniaInventors: Wouter-Jan Rappel, David Vidmar
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Publication number: 20190223743Abstract: A method and system for determining a source of a cardiac rhythm disorder includes collecting cardiac signals at a plurality of locations during a cardiac arrhythmia and identifying activation times within the cardiac signals. After computing the time-dependent phase of each region of tissue, a level of phase synchrony is determined between each pair of locations to assign a synchronization number for each pair of locations. Using the synchronization number, a spatial synchrony map is generated to identify one or more asynchronous tissue regions surrounded by regions of synchrony in the patient's heart.Type: ApplicationFiled: March 24, 2017Publication date: July 25, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Wouter-Jan RAPPEL, David VIDMAR
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Publication number: 20190104958Abstract: Methods and systems are provided for determination and mapping of vector fields which characterize wavefront motion through space and time. The inventive methods and systems utilize data from spatially-distributed locations and maps wavefront vector flow fields in an entirely automated manner. These maps can be used to characterize the activation as planar, centrifugal, or rotational. Further, the strength of rotation or divergence is determined from these fields and can be used to select spatial points of significantly increased rotational or focal activity. As applied to electrophysiological data recorded during heart rhythm disorders in patients, the inventive method provides a means of visual interpretation of complex activation maps. The information related to the strength and location of rotation and centrifugal activity during episodes of arrhythmia can guide therapies designed to treat such disorders.Type: ApplicationFiled: March 24, 2017Publication date: April 11, 2019Inventors: Wouter-Jan RAPPEL, David VIDMAR
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Publication number: 20190038157Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: ApplicationFiled: September 26, 2018Publication date: February 7, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sanjiv M. Narayan, Wouter-Jan RAPPEL
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Patent number: 10092196Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: GrantFiled: September 9, 2016Date of Patent: October 9, 2018Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans AffairsInventors: Sanjiv M. Narayan, Wouter-Jan Rappel
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Patent number: 9955879Abstract: A system to generate a representation of a rhythm disorder includes a plurality of sensors disposed at multiple locations spatially in relation to the heart, wherein cardiac information signals are sensed. A processor receives and analyzes the activation onsets of the cardiac information signals to determine an arrangement of activation onsets. A representation that indicates the clinical source of the rhythm disorder is generated based on the arrangement of the activation onsets.Type: GrantFiled: June 8, 2016Date of Patent: May 1, 2018Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Publication number: 20160374571Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: ApplicationFiled: September 9, 2016Publication date: December 29, 2016Inventors: Sanjiv M. NARAYAN, Wouter-Jan RAPPEL
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Publication number: 20160278657Abstract: A system to generate a representation of a rhythm disorder includes a plurality of sensors disposed at multiple locations spatially in relation to the heart, wherein cardiac information signals are sensed. A processor receives and analyzes the activation onsets of the cardiac information signals to determine an arrangement of activation onsets. A representation that indicates the clinical source of the rhythm disorder is generated based on the arrangement of the activation onsets.Type: ApplicationFiled: June 8, 2016Publication date: September 29, 2016Inventors: Sanjiv Narayan, Wouter-Jan Rappel
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Patent number: 9439573Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: GrantFiled: August 29, 2014Date of Patent: September 13, 2016Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans AffairsInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Patent number: 9380950Abstract: A method of detecting a cause of a heart rhythm disorder includes collecting data corresponding to activation onset time of each heart activation at multiple locations of the heart and generating an activation trail based on the sequential order of activation onset times. The activation trail is indicative of the cause of the heart rhythm disorder.Type: GrantFiled: August 12, 2013Date of Patent: July 5, 2016Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFARIS, OFFICE OF GENERAL COUNSELInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Patent number: 9375156Abstract: A system to detect a cause of a complex rhythm disorder in a human heart includes a plurality of sensors disposed spatially in relation to the heart, where the signals generated by the sensors are associated with activations of the heart. A processor collects and analyzes the signals to identify a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: GrantFiled: April 21, 2014Date of Patent: June 28, 2016Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, OFFICE OF THE GENERAL COUNSELInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Publication number: 20140371616Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: ApplicationFiled: August 29, 2014Publication date: December 18, 2014Inventors: Sanjiv Narayan, Wouter-Jan Rappel
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Patent number: 8838222Abstract: A method of treating a complex rhythm disorder of a human heart includes identifying a region of a wall of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with one or more activations of the heart. A portion of the region is selected based on the activation trail and modified to affect the activation trail.Type: GrantFiled: October 24, 2013Date of Patent: September 16, 2014Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans AffairsInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Patent number: 8838223Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: GrantFiled: October 24, 2013Date of Patent: September 16, 2014Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans AffairsInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Publication number: 20140228696Abstract: A system to detect a cause of a complex rhythm disorder in a human heart includes a plurality of sensors disposed spatially in relation to the heart, where the signals generated by the sensors are associated with activations of the heart. A processor collects and analyzes the signals to identify a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: ApplicationFiled: April 21, 2014Publication date: August 14, 2014Applicant: The Regents of the University of CaliforniaInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Publication number: 20140052127Abstract: A method of treating a complex rhythm disorder of a human heart includes identifying a region of a wall of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with one or more activations of the heart. A portion of the region is selected based on the activation trail and modified to affect the activation trail.Type: ApplicationFiled: October 24, 2013Publication date: February 20, 2014Applicant: The Regents of the University of CaliforniaInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Publication number: 20140052013Abstract: A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.Type: ApplicationFiled: October 24, 2013Publication date: February 20, 2014Applicant: The Regents of the University of CaliforniaInventors: Sanjiv Narayan, Wouter-Jan Rappel
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Publication number: 20130331718Abstract: A method of detecting a cause of a heart rhythm disorder includes collecting data corresponding to activation onset time of each heart activation at multiple locations of the heart and generating an activation trail based on the sequential order of activation onset times. The activation trail is indicative of the cause of the heart rhythm disorder.Type: ApplicationFiled: August 12, 2013Publication date: December 12, 2013Applicant: The Regents of the University of CaliforniaInventors: Sanjiv Narayan, Wouter-Jan Rappel