Patents by Inventor Wouter Vervecken

Wouter Vervecken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
    Patent number: 9347050
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: May 24, 2016
    Assignee: Oxyrane UK Limited
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noëlla Pynaert
  • Methods and materials for treatment of pompe's disease
    Patent number: 9249399
    Abstract: This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 2, 2016
    Assignee: Oxyrane UK Limited
    Inventors: Wouter Vervecken, Kathleen Camilla Telesphore Alida Maria Piens, Jan Robert Ludo Stout, Gwenda Noëlla Pynaert
  • Microorganisms genetically engineered to have modified N-glycosylation activity
    Patent number: 9222083
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: December 29, 2015
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Microorganisms genetically engineered to have modified N-glycosylation activity
    Patent number: 9206408
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 8, 2015
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • YEAST STRAINS PRODUCING MAMMALIAN-LIKE COMPLEX N-GLYCANS
    Publication number: 20150337273
    Abstract: Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosyiation pathway.
    Type: Application
    Filed: March 6, 2015
    Publication date: November 26, 2015
    Inventors: Steven Christian Jozef Geysens, Wouter Vervecken
  • METHODS AND MATERIALS FOR REDUCING DEGRADATION OF RECOMBINANT PROTEINS
    Publication number: 20150031081
    Abstract: Described herein are methods and materials for reducing degradation of recombinant proteins in fungal cells such as Yarrowia.
    Type: Application
    Filed: December 28, 2012
    Publication date: January 29, 2015
    Inventors: Wouter Vervecken, Stefan Ryckaert
  • Filamentous Fungi Having Reduced UDP-Galactofuranose Content
    Publication number: 20140377804
    Abstract: A filamentous fungal cell having reduced UDP-galactofuranose is provided. The fungal cell may, in certain embodiments, contain a nuclear genome comprising an inactivated UDP-galactopyranose mutase (UDP-galp mutase) gene and a recombinant nucleic acid for expression of a protein. Also provided are methods of producing a protein using the subject fungal cell, as well as methods of producing the subject fungal cell.
    Type: Application
    Filed: April 11, 2014
    Publication date: December 25, 2014
    Applicant: DANISCO US INC.
    Inventors: Michael Ward, Wouter Vervecken, Roland Contreras
  • Glycosylation of molecules
    Patent number: 8597906
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: December 3, 2013
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • De-mannosylation of phosphorylated N-glycans
    Publication number: 20130295603
    Abstract: Methods for demannosylating phosphorylated N-glycans on a glycoprotein are described that use a mannosidase capable of hydrolyzing a terminal alpha-1,2 mannose linkage when the underlying mannose is phosphorylated.
    Type: Application
    Filed: September 29, 2011
    Publication date: November 7, 2013
    Applicant: OXYRANE UK LIMITED
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken
  • MANNOSIDASES CAPABLE OF UNCAPPING MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGES AND DEMANNOSYLATING PHOSPHORYLATED N-GLYCANS AND METHODS OF FACILITATING MAMMALIAN CELLULAR UPTAKE OF GLYCOPROTEINS
    Publication number: 20130267473
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Application
    Filed: September 29, 2011
    Publication date: October 10, 2013
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noella Pynaert
  • METHODS AND MATERIALS FOR TREATMENT OF POMPE'S DISEASE
    Publication number: 20130243746
    Abstract: This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: OXYRANE UK LIMITED
    Inventors: Wouter Vervecken, Kathleen Camilla Telesphore Alida Maria Piens, Jan Robert Ludo Stout, Gwenda Noëlla Pynaert
  • Glycosylation of Molecules
    Publication number: 20130195835
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Application
    Filed: September 14, 2012
    Publication date: August 1, 2013
    Applicants: OXYRANE UK LIMITED, UNIVERSITEIT GENT, VIB VZW
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Glycosylation of Molecules
    Publication number: 20130190253
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Application
    Filed: September 14, 2012
    Publication date: July 25, 2013
    Applicants: OXYRANE UK LIMITED, UNIVERSITEIT GENT, VIB VZW
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • HYDROLYSIS OF MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGE TO PHOSPHO-6-MANNOSE
    Publication number: 20130158239
    Abstract: Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.
    Type: Application
    Filed: September 29, 2010
    Publication date: June 20, 2013
    Applicants: UNIVERSITEIT GENT, VRIJE UNIVERSITEIT BRUSSEL, OXYRANE UK LIMITED, VIB VZW
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Petra Sophie Tiels, Han Karel Remaut, Kathleen Camilla Telesphore Alida Maria Piens
  • YEAST STRAINS PRODUCING MAMMALIAN-LIKE COMPLEX N-GLYCANS
    Publication number: 20130053550
    Abstract: Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway.
    Type: Application
    Filed: November 19, 2010
    Publication date: February 28, 2013
    Applicant: OXYRANE UK LIMITED
    Inventors: Steven Christian Jozef Geysens, Wouter Vervecken
  • Modification of protein glycosylation in methylotrophic yeast
    Patent number: 8058053
    Abstract: The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: November 15, 2011
    Assignees: VIB, VZW, Universiteit Gent, Research Corporation Technologies, Inc.
    Inventors: Roland Contreras, Nico L. M. Callewaert, Wouter Vervecken, Vladimir Kaigorodov
  • and HAC1 nucleic acids
    Patent number: 8026083
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: September 27, 2011
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Glycosylation of Molecules
    Publication number: 20110207676
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Application
    Filed: April 27, 2011
    Publication date: August 25, 2011
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Glycosylation of Molecules
    Publication number: 20110201540
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 18, 2011
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Filamentous Fungi Having Reduced UDP-Galactofuranose Content
    Publication number: 20110104750
    Abstract: A filamentous fungal cell having reduced UDP-galactofuranose is provided. The fungal cell may, in certain embodiments, contain a nuclear genome comprising an inactivated UDP-galactopyranose mutase (UDP-galp mutase) gene and a recombinant nucleic acid for expression of a protein. Also provided are methods of producing a protein using the subject fungal cell, as well as methods of producing the subject fungal cell.
    Type: Application
    Filed: April 3, 2007
    Publication date: May 5, 2011
    Inventors: Michael Ward, Wouter Vervecken, Roland Contreras