Patents by Inventor Wouterus M. J. van Grunsven

Wouterus M. J. van Grunsven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides and nucleic acid sequences related to the Epstein Barr Virus
    Patent number: 7507804
    Abstract: The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 24, 2009
    Assignee: Akzo Nobel, N.V.
    Inventors: Jaap M. Middeldorp, Wouterus M. J. van Grunsven
  • Peptides and nucleic acid sequences related to the epstein barr virus
    Publication number: 20020169286
    Abstract: The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
    Type: Application
    Filed: December 21, 2001
    Publication date: November 14, 2002
    Inventors: Jaap M. Middeldorp, Wouterus M.J. van Grunsven
  • Peptides and nucleic acid sequences related to the Epstein Barr virus
    Patent number: 6365717
    Abstract: The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: April 2, 2002
    Assignee: Akzo Nobel, N.V.
    Inventors: Jaap M. Middeldorp, Wouterus M. J. van Grunsven
  • Peptides and nucleic acid sequences related to the Epstein Barr virus
    Patent number: 6008327
    Abstract: The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), comprising at least part of the VCA-p18 or VCA-p40 protein, encoded within the EBV open reading frames BFRF3 and BdRF1 respectively, or a functional variant thereof. The invention further relates to nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: December 28, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Jaap M. Middeldorp, Wouterus M. J. van Grunsven
  • Peptides and nucleic acid sequences related to the Epstein Barr virus
    Patent number: 5424398
    Abstract: The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), comprising at least part of the VCA-p18 or VCA-p40 protein, encoded within the EBV open reading frames BFRF3 and BdRF1 respectively, or a functional variant thereof. The invention further relates to nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: June 13, 1995
    Assignee: Akzo N.V.
    Inventors: Jaap M. Middeldorp, Wouterus M. J. van Grunsven