Patents by Inventor Wu Albert Cheng

Wu Albert Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alternatively spliced mRNA isoforms as prognostic indicators for metastatic cancer
    Patent number: 9926601
    Abstract: The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 27, 2018
    Assignees: Massachusetts Institute of Technology, Montefiore Medical Center, Albert Einstein College of Medicine, Inc.
    Inventors: Frank B. Gertler, Christopher Boyce Burge, Irina M. Shapiro, Wu Albert Cheng, John S. Condeelis, Maja H. Oktay
  • Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
    Publication number: 20160186208
    Abstract: The invention is directed to a method of mutating one or more target nucleic acid sequences in a stem cell or a zygote comprising introducing into the stem cell or zygote (i) ribonucleic acid (RNA) sequences that comprise a portion that is complementary to a portion of each of the target nucleic acid sequences and comprise a binding site for a CRISPR associated (Cas) protein; and a Cas nucleic acid sequence or a variant thereof that encodes a Cas protein having nuclease activity. The stem cell or zygote is maintained under conditions in which the target nucleic acid sequences are mutated in the stem cell or zygote. The invention is also directed to methods of producing a non human mammal carrying mutations and methods of modulating the expression and/or activity target nucleic acid sequences and cells or zygotes.
    Type: Application
    Filed: April 16, 2014
    Publication date: June 30, 2016
    Inventors: Rudolf Jaenisch, Haoyi Wang, Hui Yang, Chikdu Shivalila, Wu Albert Cheng
  • ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER
    Publication number: 20140066319
    Abstract: The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
    Type: Application
    Filed: February 24, 2012
    Publication date: March 6, 2014
    Applicants: Massachusetts Institute of Technology, Montefiore Medical Center, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Frank B. Gertler, Christopher Boyce Burge, Irina M. Shapiro, Wu Albert Cheng, John S. Condeelis, Maja H. Oktay